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Social and Behavioral Sciences

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City University of New York (CUNY)

Dissertations, Theses, and Capstone Projects

Theses/Dissertations

2015

Addiction; Alcoholism; Dependence; Dopamine; Lieber-DeCarli liquid diet; Reinforcement

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The Role Of Dependence In Alcohol Reinforcement: Neurobehavioral Mechanisms, Michal Atzram Sep 2015

The Role Of Dependence In Alcohol Reinforcement: Neurobehavioral Mechanisms, Michal Atzram

Dissertations, Theses, and Capstone Projects

The motivation to consume alcohol is complex, though physiological dependence has long been implicated in alcohol reinforcement and alcoholism. The research presented here was conducted to examine the role of alcohol dependence on voluntary alcohol consumption and preference, the validity of the Lieber-DeCarli (LD) liquid diet as a procedure to induce dependence, and the effect of alcohol administration on dopamine and endocannabinoids. While the LD diet has been used extensively to induce alcohol toxicity and teratogenic effects, there has not been research that has examined its use in the development of dependence and alcohol reinforcement. This research utilized varying periods …