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Genome-Wide Association Analysis Of Major Depressive Disorder And Its Related Phenotypes., Nagesh Ramarao Aragam

Electronic Theses and Dissertations

Major Depressive Disorder (MDD) is a complex and chronic disease that ranks fourth as cause of disability worldwide. Thirteen to 14 million adults in the U.S. are believed to have MDD and an estimated 75% attempt suicide making MDD a major public health problem. Recently several genome-wide association (GWA) studies of MDD have been reported; however, few GWA studies focus on the analysis for MDD related phenotypes such as neuroticism and age at onset of MDD. The purpose of this study is to determine risk factors for MDD, identify genome-wide genetic variants affecting neuroticism and age at onset as quantitative …

Asthma Prevalence: Focus On Prevention Management In Community Settings, Augustine M. Amenyah

Public Health Theses

Asthma prevalence continues to increase across the United States of America, affecting more than 43.1 million people and projected to affect over 50 million people by 2025. Asthma prevalence differs by demographic characteristics, such as race, ethnicity, socio-economic status, education, age and gender. Poor quality of life is common among people who suffer from asthma, in addition to school and work absenteeism. In 2008, children 5-17 years old with at least one reported asthma attack missed 10.5 million school days in the past year (CDC, 2010). Healthcare use for asthma is high and disparities remain in asthma healthcare use and …

Risk Factor Clustering Among Adolescents Infected With Or At-Risk For Chlamydia: A Descriptive Study, Elizabeth R. Wilson

Public Health Theses

STDs are a major public health epidemic in the United States with an estimated 19 million new cases occurring annually. Associated direct medical costs are estimated at $17 billion annually (CDC, 2010). Chlamydia is the most prevalent of all STDs and is also the most reported notifiable disease in the United States. While adolescents only account for an estimated 25% of the sexually active population, they account for nearly half of the 19 million cases. The higher prevalence of STDs among adolescents is most likely a reflection of multiple issues within a national socio-economic context. Additionally, the burden is even …

Steps To Evaluate The Emory Breast Center Cancer Education Class, Jillian B. Ogden

Public Health Theses

Surveillance Epidemiology and End Results (SEER) data estimates that 207,090 women will be diagnosed with and 39,840 women will die of cancer of the breast in 2011. Cancer can be a very intimidating illness and cause a great deal of anxiety. This anxiety can sometimes progress into a very serious medical problem. Interpersonal relationships, such as that between a patient and provider can influence health behavior. Communication functions of patient-provider communication such as, information exchange, uncertainty management, can improve health outcomes both directly and indirectly. For example, cancer education can help ease anxiety by familiarizing the patient with their particular …

Identifying Data Needs To Support The Public Health Program Of First Care, Rachele D. Ulysse

Public Health Theses

Abstract

Identifying Data Needs to Support the Public Health Program of First Care

Background:

First Care (FC) is a Georgia (GA) public health (PH) program funded by Title V Block Grant, whose main purpose is to provide collaborative skilled PH services for infants with LBW and VLBW (low and very low birth weight) as well as those considered at high risk for illness and disabilities.

Purpose:

1. Describe current health outcomes of GA infants less than one years of age.

* Current baselines of IMR (infant mortality rate), preterm, very low birth weight (VLBW) and low birth weight (LBW) births …

Planning, Implementation, And Formative Evaluation Of A Food Literacy Program, Heather M. Thomas

Electronic Thesis and Dissertation Repository

The overall purpose of this dissertation was to examine the planning, implementation, and formative evaluation of a community-based food literacy program for youth. Article 1 provided a summary of the community-based cooking program for at-risk youth. Objectives included the provision of applied food literacy and cooking skills education augmented with fieldtrips to local farms. Eight at-risk youth (five girls and three boys, mean age = 14.6) completed the intervention. Post intervention, five of eight participants completed in-depth interviews about their experiences.

Article 2 was a formative evaluation of the cooking program focused on gaining an understanding of participants’ (i.e., at-risk …

Demographic Associations Of Tobacco Use Among Georgia Secondary Students, Michael G. Cowart

Public Health Theses

As in years past, use of tobacco remains the leading cause of preventable death in this country. Smoking has been associated with elevated risks of 15 other forms of and has also been identified as a major cause of such chronic conditions as cardiovascular disease, cerebrovascular disease, bronchitis and emphysema. In 2008, an estimated 8.6 million Americans suffered from smoking-related chronic conditions (American Cancer Society, 2010).

As 80% of tobacco use begins in adolescence (Villanti, Boulay & Juon, 2010), this age group has long been the focus of intervention efforts. Furthermore, animal studies suggest that the adolescent brain is at …

Characterization Of A Small Animal Spect Platform For Use In Preclinical Translational Research, Dustin Ryan Osborne

Doctoral Dissertations

Imaging Iodine-125 requires an increased focus on developing an understanding of how fundamental processes used by imaging systems work to provide quantitative output for the imaging system. Isotopes like I-125 pose specific imaging problems that are a result of low energy emissions as well as how closely spaced those emissions are in the spectrum. This work seeks to characterize the performance of a small animal SPECT-CT imaging system with respect to imaging I-125 for use in a preclinical translational research environment and to understand how the performance of this system relates to critical applications such as attenuation and scatter correction. …

Geographic Disparities Associated With Stroke And Myocardial Infarction In East Tennessee, Ashley Pedigo Golden

Doctoral Dissertations

Stroke and myocardial infarction (MI) are serious conditions whose burdens vary by socio-demographic and geographic factors. Although several studies have investigated and identified disparities in burdens of these conditions at the county and state levels, little is known regarding their geographic epidemiology at the neighborhood level. Both conditions require emergency treatments and therefore timely geographic accessibility to appropriate care is critical. Investigation of disparities in geographic accessibility to stroke and MI care and the role of Emergency Medical Services (EMS) in reducing treatment delays are vital in improving health outcomes. Therefore, the objectives of this work were to: (i) classify …

Overview Of Healthcare Quality: Hospitals And Public Health Trends: Rural Vs. Urban, Sandy S. Lee

Social Sciences

No abstract provided.

Spatial Distribution Of Obesity Among West Virginia 5th Grade Children: Analysis Of The Socioeconomic, Physical, And Personal Environment, Sherry Roper

Theses and Dissertations (ETD)

Childhood obesity defined as a body mass index (BMI) at or above the 95th percentile for children of the same age and sex, is considered an epidemic in the United States. Biology and lifestyle behaviors have been identified as important factors in the development of childhood obesity; however, researchers are beginning to place more emphasis upon the impact that continual environmental exposures have upon obesity development. Environmental risk factors associated with obesity are distributed continuously over space, yet evidence suggests that burden of risk may not be evenly dispersed across a community. West Virginia (WV), a rural Appalachian community has …

An Evaluation Of A Peer Led Bystander Intervention Program To Reduce Sexual Assault Violence Among College Students, Elizabeth Madeline Childers

Graduate Theses and Dissertations

It has been reported that sexual victimization among college women is three times higher than the general population. Because of these alarming rates, sexual violence prevention has become a main concern on college campuses. Sexual violence prevention programs have been implemented and evaluated throughout the years in order to decrease the incidence of sexual violence, but very few have explored the bystander intervention component. The current study developed and evaluated a program that promoted proSocial bystander behavior through a one-time educational program utilizing peer educators. Data for this study were collected with a pre/posttest design from a Division 1 university …

Spatio-Temporal Modeling Of Arthropod-Borne Zoonotic Diseases: A Proposed Methodology To Enhance Macro-Scale Analyses, Stephen Jones

All Dissertations

Zoonotic diseases are infectious diseases that can be transmitted from or through animals to humans, and arthropods often act as vectors for transmission. Emerging infectious diseases have been increasing both in prevalence and geographic range at alarming rates the last 30 years, and the majority of these diseases are zoonotic in nature. Many zoonotic diseases are considered notifiable by the Centers for Disease Control and Prevention (CDC). However, though state regulations or contractual obligations may require the reporting of certain diseases, significant underreporting is known to exist. Because of the rich volume of information captured in health insurance plan databases, …

Effect Of Gender On The Association Of Single-Nucleotide Polymorphisms With Bipolar Disorder, Jerald Eric Mullersman

Electronic Theses and Dissertations

Bipolar disorder is a relatively common form of mental illness that depends strongly on genetic inheritance for expression. The author of this study has sought to evaluate whether the gender of subjects influences which genetic variants are associated with the disease. A portion of the cases from a previously published study were analyzed using PLINK software and the association of single-nucleotide polymorphisms was evaluated separately for all cases, for female subjects alone, and for male subjects alone. The results obtained for male subjects alone reached higher levels of statistical significance than when both genders were evaluated together or when female …

Fathers And Their Views On Discussing Sex And Sexuality With Their Daughters, Kindann M. Stone

Graduate Theses and Dissertations

The purpose of this research project was to identify characteristics and perceptions of fathers associated with discussions about sex and sexuality with their daughters. Parental communication, education, and value sharing reduces the risk of STD's and teen pregnancy. Participants were fathers (N=108) who were recruited by their daughters who were attending a Southeastern University. Demographics were utilized and researcher developed modified scales used in previous studies (citation). The newly developed scales were the Sexual Knowledge Inventory (SKI), Value of Self-Efficacy of Sexuality Communication (VSESC), Safe Sex of Self Efficacy of Sexuality Communication (SSSESC), Father's Role as Sex Educators Outcome Expectancy …

Development Of An Instrument Measuring The Perceived Attributes Of Using A Healthy Diet Innovation, Holly Ann Federico Huye

Dissertations

The Lower Mississippi Delta (LMD) is a rural region that is rich in agricultural resources but is one of the most impoverished areas in the US. Prior research has indicated LMD adults as having higher rates of obesity and diet-related chronic diseases as compared to US adults. While the need for dietary intervention in the LMD is evident, the first step in designing effective interventions is the assessment of one’s perceptions of dietary behaviors. The purpose of this research was to develop a valid and reliable instrument to assess individuals’ perceived attributes of using a healthy diet. Using the Diffusion …

The Effect Of Six Weeks Of Oral Echinacea Supplementation On Erythropoiesis, Nitric Oxide Production, And Exercise Performance, Tyler David Martin

Dissertations

The purpose of the present study was to investigate the effect of six weeks of oral Echinacea supplementation on serum erythropoietin (EPO) and erythropoietic status, plasma nitric oxide [NO], submaximal endurance exercise performance, and maximal oxygen uptake (V˙O_2max). Twenty-four males (mean ± SE): age = 25.2 ± 1.4 yr, height = 178.1 ± 1.4 cm, mass = 78.1 ± 1.6 kg, percent body fat = 12.7 ± 0.9 %, V˙O_max = 52.9 ± 0.9 mL·kg^-1·min^-1 were randomly grouped using a matched-pair, double-blind design and self-administered 8,000 mg·d^-1(5 × 400 mg × 4 …

Spatial Epidemiology And Temporal Trends Of Heart Attack And Stroke In Middle Tennessee, Doreen Busingye

Masters Theses

Despite declines in mortality risks of myocardial infarction (MI) and stroke in the US since the 1960’s, the burdens of these conditions remain high. These conditions require emergency and specialized care and therefore quick transportation of patients to appropriate hospitals is critical. Geographic disparities in MI and stroke burdens have been consistently reported in the US with the south-east having the highest risks. Most studies of geographic disparities have been performed at county or higher geographic units. Therefore, spatial patterns at neighborhood levels are unclear. Moreover, it’s important to investigate disparities at neighborhood levels to better understand neighborhood health needs. …

Analysis Of The Morbidity And Mortality Of Severe Influenza Infection In Clark County, Nevada For The 2010--2011 Influenza Season, Kindra Maureen St. Jacques

UNLV Theses, Dissertations, Professional Papers, and Capstones

Influenza circulates in the community in a fairly predictable manner each year; however, throughout the duration of any influenza season, influenza strains have the ability to evolve through antigenic mutations, viral reassortment, development of anti-viral resistance, and alterations in virulence. These changes are likely to cause illness among the unimmunized and can result in severe illness or death. Therefore, it is especially important to closely monitor severe influenza-associated hospitalizations and deaths. The University of Nevada, Las Vegas in collaboration with the Southern Nevada Health District (SNHD), Office of Epidemiology (OOE) analyzed data from the severe hospitalized influenza morbidity and mortality …

Association Between Childhood Demographics And Blood Lead Screening---Nevada Kindergarten Health Survey 2010, Lina Zhang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Lead, as a toxic substance, invades the human body, and gradually damages the organs. Oftentimes, elevated blood lead levels are not recognized until serious health issues are found. In the United States, approximately 250,000 children aged 1-5 years have elevated blood lead levels greater than 10 micrograms of lead per deciliter of blood (Centers for Disease Control and Prevention, 2004).

However, there is no effective treatment for lead poisoning. Chelation can merely decrease the blood lead levels but cannot reverse the existing damage. To prevent and control childhood lead poisoning, many studies have been conducted to investigate the sources of …

Effect Of A Work Site Exercise Program On Selected Fitness And Psychological Parameters, Kristen Ann Christiansen

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing rates of obesity continue to threaten the vitality of our nation. Health care costs are soaring and chronic diseases are reaching even the youngest populations. Physical activity is an integral component in reversing the obesity epidemic and improving the health of today's workforce. The present study sought to determine the effect of a work site exercise program on select fitness and psychological parameters. Five female employees participated in a six-week exercise program utilizing HealthBeat(TM) outdoor exercise equipment in a circuit fashion for 30 minutes, 2 days per week. Eighty percent of participants were categorized as sedentary or low-active …

Evaluation Of The Pilot Program, Pediatric Early Warning Sentinel Surveillance Program (Pewss), And Its Efficacy In Monitoring Pediatric Illness In Clark County, Nevada, Michelle Lee Lutman

UNLV Theses, Dissertations, Professional Papers, and Capstones

The influenza outbreak that occurred during 2009 stimulated the formation of several surveillance programs throughout the country. The majority monitor only influenza; however, there are several other circulating respiratory pathogens, especially within the pediatric community. These other respiratory pathogens cause a variety of illnesses, such as bronchitis, pneumonia, croup, etc. Prior research has provided the medical community with valuable information about respiratory illnesses, especially those which afflict pediatric patients. Areas of knowledge including seasonality, demographics, signs and symptoms, prevention measures, and pathogenicity, have been greatly expanded over the years. This information has been of tremendous help to the medical community …

A Comparative Study Of Indicator Bacteria Present In Ice And Soda From Las Vegas Food Establishments, Kimberly Jo Hertin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Microbial analysis has long been used as an indicator of water quality. Since the passing of the Safe Drinking Water Act in 1974, microbial standards have been strictly set by the Environmental Protection Agency (EPA) to ensure that the public health is protected from bacterial pathogens. The bacteriological quality of water generally deteriorates as it travels from water treatment facilities through the main distribution system and into private plumbing and distribution systems. For example, Heterotrophic Plate Count (HPC) values typically increase once the water has entered plumbing devices such as beverage vending machines. Upon reaching a private facility, the opportunity …

An Examination Of Diet, Acculturation And Risk Factors For Heart Disease Among Jamaican Immigrants, Carol Renee Oladele

USF Tampa Graduate Theses and Dissertations

Background: The South Florida region is home to over 85,000 Jamaican immigrants. Yet, little is known about the dietary intakes and predictors of risk of disease within this immigrant group. An assessment of dietary intakes and the development of dietary intake methodologies specific to the Jamaican population was important as it permitted accurate estimation of the nutrient intakes of this immigrant population whose dietary habits are not well documented. In addition, nothing is known about the prevalence of risk factors for heart disease or factors influencing risk factors among this immigrant group. The purpose of this study was to assess …

Maternal Mortality In Cambodia: Efforts To Meet The Millennium Development Goal For Maternal Health, Sarah Elizabeth Connell

Public Health Theses

Recent estimates of global maternal mortality indicate that for the first time since the Safe Motherhood Initiative of 1987, deaths due to pregnancy-related causes are on the decline. Defined as the death of a woman while pregnant or within 42 days of termination of pregnancy, maternal mortality is one of the strongest health statistics showing the disparity between poor and rich countries. Although a global decline is documented, challenges to reducing maternal mortality, and meeting Millennium Development Goals (MDGs) for maternal health remain, particularly in many Sub-Saharan African and Southeast Asian countries.

This study presents an assessment of Cambodia’s progress …

Awareness Of Diabetes Risk And Adoption Of Diabetes Risk Reduction Behaviors In The Presence Of Other Risk Factors In U.S Adults: An Examination Of Nhanes Data 2007-2008, Payal S. Shah

Public Health Theses

ABSTRACT

Background: Prediabetes is a precursor condition to type 2 diabetes mellitus. Previous research and clinical trials have shown that the onset of type 2 diabetes could be delayed or prevented through structured life style modifications such as dietary changes, modest weight loss and moderate-intensity exercise. This study examines U.S adults of different ethnicities that include non-Hispanic white, non-Hispanic black and Mexican Americans and whether their awareness of diabetes risk is associated with their participation in diabetes risk reduction behavior, a combination of physical activity, weight control and fat/calories intake.

Methods: The 2007-2008 National Health and Nutrition Examination Survey, NHANES, …

"Not If, But When": Sex, Risk, And Trust In Timing Gardasil Vaccine Decisions, An Exploratory Study Among Healthcare Providers And Middle-Class Parents In The U.S., Kathleen Marie Brelsford

USF Tampa Graduate Theses and Dissertations

This dissertation research explores how values regarding sexuality, morality, responsibility, protection, trust, and risk — expressed through parent, daughter, and healthcare provider relationships and interactions — inform parental decisions regarding the Gardasil® vaccine. In particular, the research examines the competing and conflicting meanings that parents and providers ascribe to vaccination and how actors position the vaccine within a wider set of negotiated, value–laden discourses. Because these narratives are situated within a larger structural field that shapes the landscape in which providers and parents interact, relevant historical and structural factors, including vaccine policy, cost, and compensation are discussed.

Dengue Fever In Tegucigalpa, Honduras: Use Of The Explanatory Model In A Sample Of Urban Neighborhoods To Contextualize And Define Dengue Fever Among Community Participants, Jose Enrique Hasemann

USF Tampa Graduate Theses and Dissertations

This project elucidated the explanatory model of dengue fever held by members of urban communities in Tegucigalpa, Honduras. The study was conducted over a four-month period from May-August of 2011, and it was divided into two stages. The first stage of the project consisted of volunteer participation with dengue fever surveillance brigades in the three communities with the highest incidence of dengue fever during the beginning of 2011. This initial stage employed participant observation as its research method. The second stage was conducted in a different community within Tegucigalpa. The primary research methods employed during the second stage of the …

The Role Of Male Partners In Childbirth Decision Making: A Qualitative Exploration With First-Time Parenting Couples, Sharon Dejoy

USF Tampa Graduate Theses and Dissertations

Fathers' attendance at childbirth is almost universal in the United States, but few researchers have addressed the role that males play in childbirth decision making. The number of technological interventions available to birthing women is increasing, as is the utilization of those interventions. The degree to which women choose or agree to these interventions plays a major role in individual and societal health outcomes. Therefore, health care policy makers and educators must find ways to help childbearing couples navigate the complex maze of decisions related to childbirth. However, policies and programs to increase shared decision making may not function as …

Fetal Growth Restriction: Molecular Mechanisms And Long-Term Outcomes, Caroline D. Albion

Electronic Thesis and Dissertation Repository

Fetal undernutrition is a major factor in the pathophysiology of fetal growth restriction (FGR) in many species, including humans. Our hypothesis is that mild maternal nutrient restriction (MNR) in a mouse provides a clinically relevant model to study FGR mechanisms and long-term effects similar to humans and the developmental origins of health and disease (DOHaD) predisposition. A MNR mouse model of FGR was developed by feeding mothers 70% normal daily caloric intake during E6.5 to E18.5 gestation. Significant reduction in fetal weight and fetal liver and lung weights with less impact on brain weight resulted, similar to asymmetric human FGR. …