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Exposure To Bisphenol A In Canada: Invoking The Precautionary Principle, Laura Vandenberg
Exposure To Bisphenol A In Canada: Invoking The Precautionary Principle, Laura Vandenberg
Laura Vandenberg
No abstract provided.
Urinary, Circulating, And Tissue Biomonitoring Studies Indicate Widespread Exposure To Bisphenol A, Laura Vandenberg, Ibrahim Chahoud, Jerrold J. Heindel, Vasantha Padmanabhan, Francisco J.R. Paumgartten, Gilbert Schoenfelder
Urinary, Circulating, And Tissue Biomonitoring Studies Indicate Widespread Exposure To Bisphenol A, Laura Vandenberg, Ibrahim Chahoud, Jerrold J. Heindel, Vasantha Padmanabhan, Francisco J.R. Paumgartten, Gilbert Schoenfelder
Laura Vandenberg
BACKGROUND: Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. Importantly, results from a large number of biomonitoring studies are at odds with the results from two toxicokinetic studies. OBJECTIVE: We examined several possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. DATA SOURCES: We examined > 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with …
Consistent Left-Right Asymmetry Cannot Be Established By Late Organizers In Xenopus Unless The Late Organizer Is A Conjoined Twin, Laura Vandenberg, Michael Levin
Consistent Left-Right Asymmetry Cannot Be Established By Late Organizers In Xenopus Unless The Late Organizer Is A Conjoined Twin, Laura Vandenberg, Michael Levin
Laura Vandenberg
How embryos consistently orient asymmetries of the left-right (LR) axis is an intriguing question, as no macroscopic environmental cues reliably distinguish left from right. Especially unclear are the events coordinating LR patterning with the establishment of the dorsoventral (DV) axes and midline determination in early embryos. In frog embryos, consistent physiological and molecular asymmetries manifest by the second cell cleavage; however, models based on extracellular fluid flow at the node predict correct de novo asymmetry orientation during neurulation. We addressed these issues in Xenopus embryos by manipulating the timing and location of dorsal organizer induction: the primary dorsal organizer was …
Bisphenol-A And The Great Divide: A Review Of Controversies In The Field Of Endocrine Disruption, Laura Vandenberg, Maricel V. Maffini, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto
Bisphenol-A And The Great Divide: A Review Of Controversies In The Field Of Endocrine Disruption, Laura Vandenberg, Maricel V. Maffini, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto
Laura Vandenberg
In 1991, a group of 21 scientists gathered at the Wingspread Conference Center to discuss evidence of developmental alterations observed in wildlife populations after chemical exposures. There, the term “endocrine disruptor” was agreed upon to describe a class of chemicals including those that act as agonists and antagonists of the estrogen receptors (ERs), androgen receptor, thyroid hormone receptor, and others. This definition has since evolved, and the field has grown to encompass hundreds of chemicals. Despite significant advances in the study of endocrine disruptors, several controversies have sprung up and continue, including the debate over the existence of nonmonotonic dose …
Perinatal Bisphenol A Exposure Increases Estrogen Sensitivity Of The Mammary Gland In Diverse Mouse Strains, Perinaaz R. Wadia, Laura Vandenberg, Cheryl M. Schaeberle, Beverly S. Rubin, Carlos Sonnenschein, Ana M. Soto
Perinatal Bisphenol A Exposure Increases Estrogen Sensitivity Of The Mammary Gland In Diverse Mouse Strains, Perinaaz R. Wadia, Laura Vandenberg, Cheryl M. Schaeberle, Beverly S. Rubin, Carlos Sonnenschein, Ana M. Soto
Laura Vandenberg
BACKGROUND: Studies of low-dose effects of xenoestrogens have yielded conflicting results that may be attributed to differences in estrogen sensitivity between the rodent strains examined. Perinatal exposure of CD-1 mice to low doses of the xenoestrogen bisphenol A (BPA) alters peripubertal mammary gland development. Future studies to assess the role of estrogen receptors as mediators of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. The sensitivity of the C57Bl6 strain to estradiol and BPA is unknown. OBJECTIVES: In the present study we examined whether the mammary glands of CD-1 and C57Bl6 mice exhibited similar …
Exposure To Environmentally Relevant Doses Of The Xenoestrogen Bisphenol-A Alters Development Of The Fetal Mouse Mammary Gland, Laura Vandenberg, Maricel V. Maffini, Perinaaz R. Wadia, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto
Exposure To Environmentally Relevant Doses Of The Xenoestrogen Bisphenol-A Alters Development Of The Fetal Mouse Mammary Gland, Laura Vandenberg, Maricel V. Maffini, Perinaaz R. Wadia, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto
Laura Vandenberg
Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and other plastic consumer products. Effects of perinatal BPA exposure on the mouse mammary gland have been observed in puberty and adulthood, long after the period of exposure has ended. The aim of this study was to examine fetal mammary gland development at embryonic day (E)18 and assess changes in the tissue organization and histoarchitecture after exposure to an environmentally relevant dose of BPA. In unexposed fetuses, the relative position of the fetus with respect to its female and male siblings …
Evidence Of Altered Brain Sexual Differentiation In Mice Exposed Perinatally To Low, Environmentally Relevant Levels Of Bisphenol A, Beverly S. Rubin, Jenny R. Lenkowski, Cheryl M. Schaeberle, Laura Vandenberg, Paul M. Ronsheim, Ana M. Soto
Evidence Of Altered Brain Sexual Differentiation In Mice Exposed Perinatally To Low, Environmentally Relevant Levels Of Bisphenol A, Beverly S. Rubin, Jenny R. Lenkowski, Cheryl M. Schaeberle, Laura Vandenberg, Paul M. Ronsheim, Ana M. Soto
Laura Vandenberg
Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of environmentally relevant exposure to BPA to affect anatomical and functional measures of brain development and sexual differentiation. Anatomical evidence of alterations in brain sexual differentiation were examined in male and female offspring born to mouse dams exposed to 0, 25, or 250 ng BPA/kg body weight per day from the evening of d 8 of …