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Microglial Disruption In Young Mice With Early Chronic Exposure To Lead, Christina Sobin, Mayra Flores Montoya, Natali Parisi, Tanner Schaub, Miguel Cervantes, Rodrigo Armijos Apr 2013

Microglial Disruption In Young Mice With Early Chronic Exposure To Lead, Christina Sobin, Mayra Flores Montoya, Natali Parisi, Tanner Schaub, Miguel Cervantes, Rodrigo Armijos

Christina Sobin, Ph.D.

The mechanisms by which early chronic lead (Pb) exposure alters brain development have not been identified. We examined neuroimmune system effects in C57BL/6J mice with Pb exposure, including levels that may be common among children in lower socioeconomic income environments. Pups were exposed via dams’ drinking water from birth to post-natal day 28 to low, high or no Pb conditions. We compared gene expression of neuroinflammatory markers (study 1); and microglial mean cell body volume and mean cell body number in dentate gyrus, and dentate gyrus volume (study 2). Blood Pb levels in exposed animals at sacrifice (post-natal day 28) …


Δ-Aminolevulinic Acid Dehydratase Single Nucleotide Polymorphism 2 And Peptide Transporter 2*2 Haplotype May Differentially Mediate Lead Exposure In Male Children, Christina Sobin, Natali Parisi, Tanner Schaub, Marisela Gutierrez, Alma Ortega Jan 2011

Δ-Aminolevulinic Acid Dehydratase Single Nucleotide Polymorphism 2 And Peptide Transporter 2*2 Haplotype May Differentially Mediate Lead Exposure In Male Children, Christina Sobin, Natali Parisi, Tanner Schaub, Marisela Gutierrez, Alma Ortega

Christina Sobin, Ph.D.

Child low-level lead (Pb) exposure is an unresolved public health problem and an unaddressed child health disparity. Particularly in cases of low-level exposure, source removal can be impossible to accomplish, and the only practical strategy for reducing risk may be primary prevention. Genetic biomarkers of increased neurotoxic risk could help to identify small subgroups of children for early intervention. Previous studies have suggested that, by way of a distinct mechanism, d-aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and/or peptide transporter 2*2 haplotype (hPEPT2*2) increase Pb blood burden in children. Studies have not yet examined whether sex mediates the effects …


Correlates Of Weight Concern And Control In A Hispanic College Student Sample., J. Blow, T. Taylor, Theodore V. Cooper, C. K. Redfearn Jan 2010

Correlates Of Weight Concern And Control In A Hispanic College Student Sample., J. Blow, T. Taylor, Theodore V. Cooper, C. K. Redfearn

Theodore V. Cooper

No abstract provided.


Differences Between Intermittent And Light Daily Smokers In A Population Of U.S Military Recruits, Theodore Cooper, Thom Taylor, Ashley Murray, Margaret Debon, Mark Vander Weg, Robert Klesges, G. Wayne Talcott Jan 2009

Differences Between Intermittent And Light Daily Smokers In A Population Of U.S Military Recruits, Theodore Cooper, Thom Taylor, Ashley Murray, Margaret Debon, Mark Vander Weg, Robert Klesges, G. Wayne Talcott

Theodore V. Cooper

No abstract provided.


Potential Demographic And Cultural Predictors Of Heavy Episodic Drinking In Hispanic College Students., Theodore V. Cooper, Jennifer Venegas, Natahsa Naylor, Brenda S. Hanson Jan 2009

Potential Demographic And Cultural Predictors Of Heavy Episodic Drinking In Hispanic College Students., Theodore V. Cooper, Jennifer Venegas, Natahsa Naylor, Brenda S. Hanson

Theodore V. Cooper

No abstract provided.


A Pilot Study Of A Brief Smoking Cessation Intervention At The Student Health Center., Theodore V. Cooper, Jennifer Venegas, Denise Rodriguez De Ybarra, Thom Taylor, Jasjit S. Ahluwalia Jan 2009

A Pilot Study Of A Brief Smoking Cessation Intervention At The Student Health Center., Theodore V. Cooper, Jennifer Venegas, Denise Rodriguez De Ybarra, Thom Taylor, Jasjit S. Ahluwalia

Theodore V. Cooper

No abstract provided.


Obesity-Relevant Behaviors: Patterns And Correlates In A Hispanic College Sample., D. Hu, T. J. Taylor, Theodore V. Cooper Jan 2009

Obesity-Relevant Behaviors: Patterns And Correlates In A Hispanic College Sample., D. Hu, T. J. Taylor, Theodore V. Cooper

Theodore V. Cooper

No abstract provided.


Predictors Of Amount Smoked Per Day In Light Smoking College Students: A 7 Day Diary Assessment., Thom Taylor, Theodore V. Cooper Jan 2009

Predictors Of Amount Smoked Per Day In Light Smoking College Students: A 7 Day Diary Assessment., Thom Taylor, Theodore V. Cooper

Theodore V. Cooper

No abstract provided.


Characteristics Associated With Smoking In A Hispanic Sample., D. Rodriguez Esquivel, Theodore V. Cooper, J. A. Blow, M. R. Resor Jan 2009

Characteristics Associated With Smoking In A Hispanic Sample., D. Rodriguez Esquivel, Theodore V. Cooper, J. A. Blow, M. R. Resor

Theodore V. Cooper

No abstract provided.


An Assessment Of Obese And Non Obese Girls’ Metabolic Rate During Television Viewing, Reading, And Resting., Theodore V. Cooper, L. M. Klesges, M. W. Debon, R. C. Klesges, M. L. Shelton Jan 2006

An Assessment Of Obese And Non Obese Girls’ Metabolic Rate During Television Viewing, Reading, And Resting., Theodore V. Cooper, L. M. Klesges, M. W. Debon, R. C. Klesges, M. L. Shelton

Theodore V. Cooper

No abstract provided.


General And Smoking Cessation Related Weight Concerns In Veterans., Theodore V. Cooper, M. Dundon, B. M. Hoffman, C. J. Stoever Jan 2006

General And Smoking Cessation Related Weight Concerns In Veterans., Theodore V. Cooper, M. Dundon, B. M. Hoffman, C. J. Stoever

Theodore V. Cooper

No abstract provided.


The Effects Of Ppa And Nicotine Gum On Cessation Rates And Post Cessation Weight Gain In Women., Theodore V. Cooper, R. C. Klesges, M. W. Debon, S. M. Zbikowski, K. C. Johnson, L. Clemens Jan 2005

The Effects Of Ppa And Nicotine Gum On Cessation Rates And Post Cessation Weight Gain In Women., Theodore V. Cooper, R. C. Klesges, M. W. Debon, S. M. Zbikowski, K. C. Johnson, L. Clemens

Theodore V. Cooper

No abstract provided.


Correlates Of Adherence With Transdermal Nicotine., Theodore V. Cooper, M. W. Debon, M. Stockton, T. A. Steenbergh, D. Sherrill-Mittleman, L. C. Jennings, R. C. Klesges Jan 2004

Correlates Of Adherence With Transdermal Nicotine., Theodore V. Cooper, M. W. Debon, M. Stockton, T. A. Steenbergh, D. Sherrill-Mittleman, L. C. Jennings, R. C. Klesges

Theodore V. Cooper

No abstract provided.


A Prospective Evaluation Of The Relationships Between Smoking Dosage And Body Mass Index In An Adolescent, Biracial Cohort., Theodore V. Cooper, R. C. Klesges, L. Robinson, S. Zbikowski Jan 2003

A Prospective Evaluation Of The Relationships Between Smoking Dosage And Body Mass Index In An Adolescent, Biracial Cohort., Theodore V. Cooper, R. C. Klesges, L. Robinson, S. Zbikowski

Theodore V. Cooper

No abstract provided.