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Modifiable Risk Factors For Hypertensive Disorders Of Pregnancy Among Latina Women, Shannon Renee Turzanski Fortner May 2009

Modifiable Risk Factors For Hypertensive Disorders Of Pregnancy Among Latina Women, Shannon Renee Turzanski Fortner

Open Access Dissertations

Hypertensive disorders of pregnancy affect approximately 8% of pregnancies, and can lead to serious complications for both mother and child. While Latinas are at two-fold increased risk of preeclampsia relative to non-Latina white women, little research on hypertension in pregnancy has been conducted in this population. Furthermore, there are few modifiable risk factors for hypertensive pregnancy. Therefore, we examined associations between psychosocial stress, physical activity, and pre-pregnancy BMI and gestational weight gain and hypertensive disorders of pregnancy using data from the Latina GDM Study, a prospective cohort study of 1,231 women. The first study evaluated the association between perceived stress …


Detrimental Effects Of Inactivity On Insulin Action, Brooke Rene Stephens May 2009

Detrimental Effects Of Inactivity On Insulin Action, Brooke Rene Stephens

Open Access Dissertations

Inactivity reduces insulin action. Energy surplus causes similar reductions to insulin action. Unless energy intake is reduced to match low energy expenditure during inactivity, a concurrent energy surplus may account for the lower insulin action. This study evaluated the effect of inactivity (sitting) with and without energy surplus on insulin action. Fourteen young (26.1 ± 4.5 years (M ± SD)), lean (23.7 ± 7.1% fat), fit (VO 2peak = 49.1 ± 3.3 ml*kg -1 *min -1 ) men (n=7) and women (n=7) completed each of 3, 24-hour conditions: an active condition (i.e. high energy expenditure with energy intake matched to …


Physical Activity And Maternal/Fetal Outcomes In A Pregnant Latina Population, Audra L Gollenberg Feb 2009

Physical Activity And Maternal/Fetal Outcomes In A Pregnant Latina Population, Audra L Gollenberg

Doctoral Dissertations 1896 - February 2014

Physical activity guidelines encouraging activity among healthy pregnant women have been issued by the Centers for Disease Control and Prevention, yet Latina women remain more sedentary than non-Latina white women. Latina women are also at higher risk for gestational diabetes mellitus and, among Latina women, Puerto Rican women have the highest rates of low birth weight and preterm-related infant death. This dissertation utilized data from the Latina GDM study, a prospective cohort study of 1,231 Latina women recruited early in pregnancy and followed through delivery. Participants were interviewed in early and mid pregnancy for assessment of sociodemographics, acculturation, medical, and …


Do Metabolic And Psychosocial Responses To Exercise Explain Ethnic/Racial Disparities In Insulin Resistance?, Rebecca E Hasson Feb 2009

Do Metabolic And Psychosocial Responses To Exercise Explain Ethnic/Racial Disparities In Insulin Resistance?, Rebecca E Hasson

Doctoral Dissertations 1896 - February 2014

Introduction . Non-Hispanic blacks (blacks) are more insulin resistant compared to non-Hispanic whites (whites), increasing their risk for Type 2 diabetes. The role played by ethnic/racial disparities in the response to physical activity in mediating those higher rates of insulin resistance in blacks is unknown. Because the beneficial effects of exercise are transient and require subsequent doses of exercise to maintain the effect; the metabolic and psychosocial responses to single exercise bouts have strong implications for both opposing insulin resistance and raising the probability that an individual will continue to exercise. Purpose . To compare the metabolic and psychosocial responses …


Approaches To Estimation Of Haplotype Frequencies And Haplotype-Trait Associations, Xiaohong Li Feb 2009

Approaches To Estimation Of Haplotype Frequencies And Haplotype-Trait Associations, Xiaohong Li

Doctoral Dissertations 1896 - February 2014

Characterizing the genetic contributors to complex disease traits will inevitably require consideration of haplotypic phase, the specific alignment of alleles on a single homologous chromosome. In population based studies, however, phase is generally unobservable as standard genotyping techniques provide investigators only with data on unphased genotypes. Several statistical methods have been described for estimating haplotype frequencies and their association with a trait in the context of phase ambiguity. These methods are limited, however, to diploid populations in which individuals have exactly two homologous chromosomes each and are thus not suitable for more general infectious disease settings. Specifically, in the context …