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Menthol In Electronic Cigarettes: A Contributor To Respiratory Disease?, Vijayalekshmi Nair, Malcolm Tran, Rachel Z. Behar, Song Zhai, Xinping Cui, Rattapol Phandthong, Yuhuan Wang, Songqin Pan, Wentai Luo, James F. Pankow, David C. Volz, Prue Talbot
Menthol In Electronic Cigarettes: A Contributor To Respiratory Disease?, Vijayalekshmi Nair, Malcolm Tran, Rachel Z. Behar, Song Zhai, Xinping Cui, Rattapol Phandthong, Yuhuan Wang, Songqin Pan, Wentai Luo, James F. Pankow, David C. Volz, Prue Talbot
Civil and Environmental Engineering Faculty Publications and Presentations
Menthol is widely used in tobacco products. This study compared the effects of menthol on human bronchial epithelium using submerged cultures, a VITROCELL® cloud chamber that provides air liquid interface (ALI) exposure without solvents or heating, and a Cultex ALI system that delivers aerosol equivalent to that inhaled during vaping. In submerged culture, menthol significantly increased calcium influx and mitochondrial reactive oxygen species (ROS) via the TRPM8 receptor, responses that were inhibited by a TRPM8 antagonist. VITROCELL® cloud chamber exposure of BEAS-2B monolayers increased mitochondrial protein oxidation, expression of the antioxidant enzyme SOD2, activation of NF-κB, and secretion of inflammatory …