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Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Theses and Dissertations
The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …
Intention To Deceive Alters Access To Semantic Memory, James Nye
Intention To Deceive Alters Access To Semantic Memory, James Nye
Theses and Dissertations
I conceptualize a theory of deception within the perspective of discourse and pragmatics while choosing to examine the decision to engage in deception within the perspective of cognitive psychology. Currently, cognitive perspectives of deception have emphasized that inhibitory control of one’s motor processes are vital because in order to respond deceptively, one must prevent honest behavior from leaking into one’s actions. Although indirect evidence for inhibition is heavily linked with deception, current empirical data connecting motoric control with deceptive responses has been difficult to observe. I propose a theoretical perspective that shifts the role of inhibitory control in deception away …