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The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson
The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson
Theses and Dissertations
There is a growing consensus, based on several converging lines of evidence, which suggests schizophrenia is the product of a developmental insult occurring in the late 2 nd or early 3 rd trimester. Additionally, it has been observed that adults who abuse the noncompetitive NMDA antagonist PCP present with symptoms that mimic schizophrenia, such as hallucinations, formal thought disorder, delusions, unstable or flattened affect, social withdrawal, and impaired cognition. Thus, several labs have attempted to use early postnatal PCP administration in rodents as a drug model of schizophrenia. The current study investigated the cognitive effects of early postnatal PCP administration …
Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting
Cognitive Mechanisms Of Memory Impairment Following Traumatic Brain Injury, Mark D. Whiting
Theses and Dissertations
Memory impairment is common following traumatic brain injury (TBI). In recent years, researchers have demonstrated that the processes underlying memory formation (working memory, encoding, consolidation, and retrieval) are interrelated but dissociable events.The following study was designed to determine how these processes contribute to memory impairment following experimental TBI in the rat. Experiment 1 indicated thatTBI induces severe working memory deficits in a delayed non-matching-to-place task.Although all animals displayed intact acquisition, only injured animals displayed poor performance as the delay between the sample and choice phases was increased.Experiment 2 was designed to determine if TBI produces a transient period of posttraumatic …