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Aging Is Associated With A Prefrontal Lateral-Medial Shift During Picture-Induced Negative Affect, C. M. Van Reekum, S. M. Schaefer, R. C. Lapate, Catherine Norris, P. A. Tun, M. E. Lachman, C. A. Ryff, R. J. Davidson
Aging Is Associated With A Prefrontal Lateral-Medial Shift During Picture-Induced Negative Affect, C. M. Van Reekum, S. M. Schaefer, R. C. Lapate, Catherine Norris, P. A. Tun, M. E. Lachman, C. A. Ryff, R. J. Davidson
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The capacity to adaptively respond to negative emotion is in part dependent upon lateral areas of the prefrontal cortex (PFC). Lateral PFC areas are particularly susceptible to age-related atrophy, which affects executive function (EF). We used structural and functional magnetic resonance imaging (MRI) to test the hypothesis that older age is associated with greater medial PFC engagement during processing of negative information, and that this engagement is dependent upon the integrity of grey matter structure in lateral PFC as well as EF. Participants (n = 64, 38–79 years) viewed negative and neutral scenes while in the scanner, and completed cognitive …