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Annual Research Review: The Power Of Predictability – Patterns Of Signals In Early Life Shape Neurodevelopment And Mental Health Trajectories, Elysia Poggi Davis, Laura M. Glynn Feb 2024

Annual Research Review: The Power Of Predictability – Patterns Of Signals In Early Life Shape Neurodevelopment And Mental Health Trajectories, Elysia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant …


Development, Line By Line: An Introspective Case Study On Narrative Identity And Development Through Poetry, Milla Miller Oct 2023

Development, Line By Line: An Introspective Case Study On Narrative Identity And Development Through Poetry, Milla Miller

WWU Honors College Senior Projects

Situated at the intersection of creative writing and psychology, this project analyzes the author’s adolescent poetry alongside her current work to explore psychosocial and narrative identity development. Specifically, the work contrasts poems written about developmental stages in process with those written in reflection of previous stages in order to reveal how the understanding of self evolves. In addition to the complexities revealed by these temporal differences, structural elements unique to the poems provide further levels of understanding: choice of form and figurative dexterity show cognitive and narrative advancement; themes reveal psychosocial conflicts; and repetition across a poetic lifespan identifies the …


Pediatric Providers’ Experiences Assessing Young Children’S Emotions And Behaviors, Vaibhavi Venkataramanan, Akira Isaac B.S., Sara Bufferd Ph.D. Sep 2023

Pediatric Providers’ Experiences Assessing Young Children’S Emotions And Behaviors, Vaibhavi Venkataramanan, Akira Isaac B.S., Sara Bufferd Ph.D.

The Cardinal Edge

Introduction: Preschool-aged children experience anxiety and mood-related emotions (e.g., irritability, fears) and behaviors (e.g., tantrums) that are developmentally normative, but can overlap with psychopathology, making assessment challenging (Bufferd et al.,2016). Most children see pediatric medical providers annually, and providers can evaluate them. However, providers face challenges like limited training and time (Bean et al.,2000;Heneghan et al.,2008). Accurate and early identification of emotional and behavioral difficulties is critical to support young children’s mental health and prevent worsening problems.

Methods: Participants included N=22 pediatricians who see 3-5-year-old children in their practice. Pediatricians completed an online survey about their experiences assessing young …


Autism, Comorbidities, And Adaptive Functioning: A Potential Moderator, Joshua J. Montrenes Jul 2023

Autism, Comorbidities, And Adaptive Functioning: A Potential Moderator, Joshua J. Montrenes

LSU Doctoral Dissertations

Deficits in adaptive functioning and the presence of comorbid symptomatology are both commonly associated with autism spectrum disorder (ASD). Previous research has identified relationships between functional level (e.g., intellectual quotient [IQ], adaptive functioning [AF]) and comorbid symptomatology in ASD. However, further insight into the relationship between AF, comorbid psychopathology, and ASD is unclear. Specifically, how AF affects the relationship between ASD and comorbid conditions is not well understood. Whether AF moderates the relationship between autism symptom severity and comorbid symptom severity in toddlers with ASD was examined. ASD symptom severity positively correlated with comorbid symptom severity across domains and negatively …


Latinas In Leadership Positions In The United States: Theories, Characteristics, And Recommendations, Fernanda Ibanez Jun 2023

Latinas In Leadership Positions In The United States: Theories, Characteristics, And Recommendations, Fernanda Ibanez

College of Science and Health Theses and Dissertations

In the United States, Latinas are one of the fastest growing populations in the workforce today. Despite increased presence in the labor market, it has not resulted in significant increases in the representation of Latinas in top and middle level leadership positions. This thesis details the current state of Latinas as leaders, as well as the theoretical background pertaining to leadership styles and challenges that Latinas face. Finally, the thesis aims to serve as a resource for Latinas currently occupying a leadership role, or looking to occupy one in the future, by offering recommendations of characteristics and behaviors that relate …


Motor Milestone Acquisition And Sleep-Related Learning And Development In Infancy, Aaron Demasi Jun 2023

Motor Milestone Acquisition And Sleep-Related Learning And Development In Infancy, Aaron Demasi

Dissertations, Theses, and Capstone Projects

The aim of this dissertation is to summarize and extend work in the field of infant sleep and motor development. Chapter 1 summarizes what is currently known about typical infant sleep development and the way that sleep impacts learning throughout infancy. Chapter 2 describes two experiments showing the importance of napping and night sleep in the consolidation of gross motor learning. Given that sleep is beneficial for learning throughout human infancy, the remainder of the dissertation investigates how learning (in this case, motor development) impacts sleep. Chapter 3 establishes the possible role of sleep-dependent movement in sleep disruption resulting from …


Temporal Relevance Of Parent Qualities And Behaviors For Predicting Young Adults’ Emotion Regulation And Romantic Relationships, Saleena Wilson May 2023

Temporal Relevance Of Parent Qualities And Behaviors For Predicting Young Adults’ Emotion Regulation And Romantic Relationships, Saleena Wilson

Masters Theses, 2020-current

The present study sought to compare the utility of adolescents’ parental relationship qualities and behaviors for predicting young adult emotion regulation as well as the mediating role of emotion regulation in the intergenerational transmission of relationship qualities and behaviors. Early adolescence is characterized by the emergence of new emotions, responsibilities, and budding romantic relationships. Parental relationships with positive qualities may provide a safe environment for teens to explore these unfamiliar experiences. In late adolescence, teens depend less on this secure base but benefit from the utilization of specific relationship behaviors, modeled to them by their parents, in increasingly important …


International Strategies For Addressing The Needs Of Children With Disabilities: Comparing Pediatric Therapy Services In Italy And The United States, Cassidy Hearn, Lillian Hsiao, Lavinia Fanelli, Regina Harbourne May 2023

International Strategies For Addressing The Needs Of Children With Disabilities: Comparing Pediatric Therapy Services In Italy And The United States, Cassidy Hearn, Lillian Hsiao, Lavinia Fanelli, Regina Harbourne

Physical Therapy Projects

This paper introduces and compares the professions of Neuro and Psychomotor Therapist of Developmental Age and pediatric physical therapy. Although pediatric physical therapy practice is prevalent in the United States, Italy utilizes another profession which encompasses many features of physical therapy, but also incorporates neuropsychological factors, specifically for children.


A Novel Measure Of Narrative Self-Functioning And Its Role In The Transformative Potential Of Psychedelic Experience Across Clinical And Non-Clinical Participants, Nicole M. Amada Feb 2023

A Novel Measure Of Narrative Self-Functioning And Its Role In The Transformative Potential Of Psychedelic Experience Across Clinical And Non-Clinical Participants, Nicole M. Amada

Dissertations, Theses, and Capstone Projects

The eudaimonic field of well-being is founded on the idea that self-knowledge and the realization of one’s potential is at the heart of what it means to strive for well-being. While the “self” is at the core of this perspective, theories derived from this field have yet to incorporate neurocognitive conceptualizations of the self, and account for the collection of self-referential cognitions that influence striving for well-being. Such a theory and measure could fill this theoretical gap and be applied in person centered interventions to capture change in these processes over time. One such intervention utilizes psychedelic experience as a …


Planning An Escape: Considerations For The Development Of Applied Escape Rooms, Shawn M. Doherty, Andrew Griggs, Elizabeth Lazzara, Joseph Keebler, Tara N. Cohen, Bruce L. Gewertz Jan 2023

Planning An Escape: Considerations For The Development Of Applied Escape Rooms, Shawn M. Doherty, Andrew Griggs, Elizabeth Lazzara, Joseph Keebler, Tara N. Cohen, Bruce L. Gewertz

Publications

Background. Teams are essential to a wide array of applications and organizations often utilize varying interventions to improve the effectiveness of their teams. Due to their collaborative and modifiable characteristics, escape rooms are being increasingly utilized as an avenue to both deliver team interventions and to function as testbeds in research. Escape rooms are complex, interdependent activities which warrant careful planning to be effectively implemented. Despite the growing literature base concerning escape rooms, there is still limited practical guidance to inform the development of an escape room. Aim. The purpose of this article is to provide seven considerations that are …


On-Line Behavior And Cognitive Development, Nunzio Joseph Crowley Jan 2023

On-Line Behavior And Cognitive Development, Nunzio Joseph Crowley

Selected Full-Text Master Theses 2021-

Parents of 128 children in a rural elementary school provided information on home Internet access and children’s online activities. Children were individually administered four measures of cognitive development (expressive language, metacognition, visual perception, and auditory memory) and were asked to define ten Internet terms (e.g., email, chat, website). The ability to define an Internet term was assumed to be indicative of experience with that application. Parent response to the open-ended item “what does your child do when he/she uses the Internet at home” was thematically organized into four types of Internet behavior: learn, play, browse, and communicate. Children’s ability to …


Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott Jan 2023

Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott

Graduate Theses, Dissertations, and Problem Reports

For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …


A Close Look At The Connections Between Mental-State Talk, Theory Of Mind, And Source Monitoring During Parent-Child Reminiscing Of Emotional Events, Mallory Earnshaw Jan 2023

A Close Look At The Connections Between Mental-State Talk, Theory Of Mind, And Source Monitoring During Parent-Child Reminiscing Of Emotional Events, Mallory Earnshaw

Theses and Dissertations (Comprehensive)

Autobiographical memories play a critical role in shaping personal identity, regulating emotions, and guiding future behaviour. Reminiscing about these memories can be particularly beneficial for coping with negative experiences. This study investigated the connections between mental-state talk, theory of mind, and source monitoring in parent-child reminiscing, and how it can be influenced by remembering enjoyable versus frustrating events. This study involved children ages 3-8 (N = 50) and consisted of two sessions. In the first session, the child reminisced with their parent about an enjoyable and frustrating event and completed two source-monitoring tasks. In the second session, the child …


Effective Succession Planning And Organizational Development For Behavioral Health Leadership, Amanda Brown Jan 2023

Effective Succession Planning And Organizational Development For Behavioral Health Leadership, Amanda Brown

Walden Dissertations and Doctoral Studies

High turnover rates can challenge an organization's ability to provide quality care to clients, maintain a safe environment, and achieve strategic goals. Effective retention strategies can allow the organization to grow and develop to continue to provide services for those in need. The focus of this study was identifying how an organization can improve its retention strategies, create succession plans, and decrease turnover to encourage organizational growth. The Baldrige Excellence Framework was used to guide the study, focusing on leadership, workforce, operations, and management. Data were collected through multiple sources. Semi structured interviews were used to gather data through open-ended …


The Strong Black Woman Schema: How It Informs The Gendered Racial Identity Development Of Black College Women/Non-Binary Students And Their Navigation Of Pwis, Whitney Ngozi Akalugwu Jan 2023

The Strong Black Woman Schema: How It Informs The Gendered Racial Identity Development Of Black College Women/Non-Binary Students And Their Navigation Of Pwis, Whitney Ngozi Akalugwu

MSU Graduate Theses

The strong Black woman schema (SBW) is known to be a salient aspect of Black womanhood. This culturally specific schema can be understood as a protective factor against the social inequities that Black women are subjected to. However, not much is known on how the SBW schema informs Black college women’s gendered racial identity development and how it informs their navigation of PWIs. The purpose of this study is to explore the strong Black woman schema and how it informs the gendered racial identity development of Black college women/non-binary students and their navigation of PWIs. This study will also address …


The Relationship Between Young Adult Attachment And Loneliness Factors With Their Childhood Social Media Usage Patterns, Kenneth Walter Mark Dec 2022

The Relationship Between Young Adult Attachment And Loneliness Factors With Their Childhood Social Media Usage Patterns, Kenneth Walter Mark

Doctoral Dissertations and Projects

Social media use has become an integral and often ignored part of children’s lives because it is rationalized not to be detrimental to their future development. However, childhood social media use was associated with insecure attachment styles and possible loneliness issues emerging in young adulthood. Past research examined social media use and secular attachment in the present only, without examining spiritual attachment or loneliness levels. This is the first research study to explore longitudinally the relationship between past childhood social media use and current young adult (aged 18-24) secular attachment, spiritual attachment, and loneliness levels. The population (N = 149) …


Context-Specific Conceptualizations Of Death In Early Childhood, Spencer Hart Winter Dec 2022

Context-Specific Conceptualizations Of Death In Early Childhood, Spencer Hart Winter

Capstone Projects and Master's Theses

Despite cultural myths and social taboos, young children are capable of understanding death and death concepts. Previous research has demonstrated that children have a varied and complex understanding of death that is influenced by their age, family culture, and previous experience. This study aims to differentiate children’s death concept depending on context, including children’s magical thinking, namely the difference between the deaths of a human, an animal, and an electronic toy. Using a modified version of the Death Concept Questionnaire, preschool-aged (3 to 5 years old) children (n=7) were presented with short video clips of a human, a dog, and …


Childhood Adversities And The Impact On Development, Karey Womack Dulaney Nov 2022

Childhood Adversities And The Impact On Development, Karey Womack Dulaney

Doctoral Dissertations and Projects

Experiences in life are crucial in determining how one’s development will progress throughout their lifespan, with many of the factors occurring in early childhood. The factors include but are not limited to adversities experienced at an early age, toxic stress, and childhood trauma. Childhood adversities can impact a child’s cognitive development and biological systems. Children living in adverse situations are at a greater risk of not reaching their full developmental potential in life. Although previous research and literature discuss and demonstrate the cruciality of early childhood interventions to mitigate adverse childhood experiences, gaps in the research exist for individual interventions, …


The Proximal Zone Of Intercultural Development (Pzid), Rachid Oulahal Nov 2022

The Proximal Zone Of Intercultural Development (Pzid), Rachid Oulahal

Papers from the International Association for Cross-Cultural Psychology Conferences

This article presents results from a comparative analysis of intercultural experiences between French and Singaporean participants. A set of questions was proposed online in order to identify temporalities of an intercultural experience (early and late interculturation) as well as the level of this experience (intrapsychic, intersubjective and intergroup interculturation). Our sample consists of 246 participants (144 in France and 102 in Singapore). France and Singapore were chosen as research fields because of their difference in terms of cultural difference management: a universalist cultural model for France and a pluralist cultural model for Singapore.

A quantitative analysis allows us to identify …


Terminal Field Volume Of The Glossopharyngeal Nerve In Adult Rats Reverts To Prepruning Size Following Microglia Depletion With Plx5622, Andrew J. Riquier, Suzanne I. Sollars Oct 2022

Terminal Field Volume Of The Glossopharyngeal Nerve In Adult Rats Reverts To Prepruning Size Following Microglia Depletion With Plx5622, Andrew J. Riquier, Suzanne I. Sollars

Psychology Faculty Publications

Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) of the rat are a prime example of developmental pruning, undergoing an approximate 66% reduction in volume from postnatal day 15 (P15) to P25. Later in adulthood, developmental GL pruning can be experimentally reversed, expanding to preweaning volumes, suggesting mature volumes may be actively maintained throughout the life span. Microglia are central nervous system glia cells that perform pruning and maintenance functions in other sensory …


Moderating Factors In The Relationship Between Bully Victimization And Psychosomatic Symptoms, Tonya Paulson Oct 2022

Moderating Factors In The Relationship Between Bully Victimization And Psychosomatic Symptoms, Tonya Paulson

Theses and Graduate Projects

The purpose of this study was to investigate the relationship between bully victimization and psychosomatic symptoms, and to examine the protective influence of perceived parent and peer support across developmental age groups. Bully victimization frequency, somatic symptom severity, perceived parent support, and perceived peer support were assessed using archival data from 7,304 youth who participated in the 2009-2010 Health Behavior in School-Aged Children (HBSC) U.S. survey, excluding perpetrators of bullying. Bully victimization and somatic symptoms were significantly positively correlated. Older adolescents consistently reported more severe somatic symptoms, but age did not moderate the relationship between bullying and somatic symptoms. Higher …


Early Life Exposure To Unpredictable Parental Sensory Signals Shapes Cognitive Development Across Three Species, Elyssia Poggi Davis, Kari Mccormack, Hina Arora, Desiree Sharpe, Annabel K. Short, Jocelyne Bachevalier, Laura M. Glynn, Curt A. Sandman, Hal S. Stern, Mar Sanchez, Tallie Z. Baram Oct 2022

Early Life Exposure To Unpredictable Parental Sensory Signals Shapes Cognitive Development Across Three Species, Elyssia Poggi Davis, Kari Mccormack, Hina Arora, Desiree Sharpe, Annabel K. Short, Jocelyne Bachevalier, Laura M. Glynn, Curt A. Sandman, Hal S. Stern, Mar Sanchez, Tallie Z. Baram

Psychology Faculty Articles and Research

Exposure to early life adversity has long term consequences on cognitive function. Most research has focused on understanding components of early life adversities that contribute to later risk, including poverty, trauma, maltreatment, and neglect. Whereas these factors, in the aggregate, explain a significant proportion of emotional and cognitive problems, there are serious gaps in our ability to identify potential mechanisms by which early life adversities might promote vulnerability or resilience. Here we discuss early life exposure to unpredictable signals from the caretaker as an understudied type of adversity that is amenable to prevention and intervention. We employ a translational approach …


Consistency Of Sleep Across Development And Relations To Executive Functions; Applications To Emerging Adults Transitioning To College And Adolescents With Spina Bifida, Laura Nicholson Oct 2022

Consistency Of Sleep Across Development And Relations To Executive Functions; Applications To Emerging Adults Transitioning To College And Adolescents With Spina Bifida, Laura Nicholson

Dissertations

College Students, Development, Executive Functioning, Inhibition, Sleep consistency, Spina Bifida


Auditory Affective Processing, Musicality, And The Development Of Misophonic Reactions, Solena Mednicoff, Sivan Barashy, Destiny Gonzales, Stephen D. Benning, Joel S. Snyder, Erin Hannon Sep 2022

Auditory Affective Processing, Musicality, And The Development Of Misophonic Reactions, Solena Mednicoff, Sivan Barashy, Destiny Gonzales, Stephen D. Benning, Joel S. Snyder, Erin Hannon

Psychology Faculty Research

Misophonia can be characterized both as a condition and as a negative affective experience. Misophonia is described as feeling irritation or disgust in response to hearing certain sounds, such as eating, drinking, gulping, and breathing. Although the earliest misophonic experiences are often described as occurring during childhood, relatively little is known about the developmental pathways that lead to individual variation in these experiences. This literature review discusses evidence of misophonic reactions during childhood and explores the possibility that early heightened sensitivities to both positive and negative sounds, such as to music, might indicate a vulnerability for misophonia and misophonic reactions. …


Reduced Social Contact And Attachment Insecurity As Predictors Of Loneliness During Covid-19: A Two-Month Experience Sampling Study, Katie C. Lewis, Michael J. Roche, Fiona Brown, Jane G. Tillman Sep 2022

Reduced Social Contact And Attachment Insecurity As Predictors Of Loneliness During Covid-19: A Two-Month Experience Sampling Study, Katie C. Lewis, Michael J. Roche, Fiona Brown, Jane G. Tillman

Psychology Faculty Publications

The impact of reduced social contact on mental health during the COVID-19 pandemic has been identified as a major public health concern. While personality factors such as attachment style have been associated with psychological distress during the pandemic, the longitudinal relevance of these factors and the role of daily social contact in mitigating distress remains poorly understood. This study evaluated the impact of social contact and attachment style on changes in loneliness over an 8-week experience sampling period during the COVID-19 pandemic. A general adult sample (n = 184) recruited online completed measures of psychological distress, attachment, and loneliness via …


Examining The Relationships Between Socio-Cognitive Factors And Neural Synchrony During Movie Watching Across Development, Kathleen M. Lyons Aug 2022

Examining The Relationships Between Socio-Cognitive Factors And Neural Synchrony During Movie Watching Across Development, Kathleen M. Lyons

Electronic Thesis and Dissertation Repository

While different cognitive abilities mature, the conscious experiences of children likely become richer and more elaborate. A challenge in investigating relationships between cognitive development and real-world experiences is having measures that assess naturalistic processing. Movie watching offers a solution, since following the plot of a film requires cognitive processes that are similar to real-world experiences. When different adults watch the same film, their brain activity begins to align (known as neural synchrony). The strength of this alignment has been shown to reflect the degree to which different individuals are having a similar experience of the movie. While this phenomenon has …


The Front Lines Of Student Success: A Phenomenography Exploring The Background And Knowledge Of Primary Role Academic Advisors In Higher Education, Alicia N. Abney Aug 2022

The Front Lines Of Student Success: A Phenomenography Exploring The Background And Knowledge Of Primary Role Academic Advisors In Higher Education, Alicia N. Abney

Electronic Theses and Dissertations

The purpose of this qualitative, phenomenographic study was to understand the experiences, backgrounds, and perspectives of new, primary role academic advisors at four-year public institutions in the United States. Research on advising has provided insight into advising best practices and the student perceptions of academic advising; however, there is little research illustrating current primary role academic advisors and their experience, or perhaps lack thereof.

To receive highly coveted federal and state funding, higher education institutions must show growth in student success. Academic advisors are on the front lines of student success because they are tasked with the responsibility of retaining …


Developmental Differences In The Learning And Consolidation Of Linguistic Regularities, Sarah Berger Jul 2022

Developmental Differences In The Learning And Consolidation Of Linguistic Regularities, Sarah Berger

Electronic Thesis and Dissertation Repository

Relative to adults, children have a well-known advantage for learning linguistic regularities, which could be partially driven by their deeper sleep. To examine the relationship between consolidation and language learning across development, children and adults learned a novel article system with an implicit grammatical rule. Participants performed a judgment task on phrases containing the novel articles before and after a night of EEG-monitored sleep. We found that rule sensitivity emerged rapidly in children, whereas it did not emerge until the second session in adults. Children demonstrated better generalization of the rule than adults. Consolidation effects showed a developmental double dissociation, …


On The Catholic Identity Of Students And Schools: Value Propositions For Catholic Education, Daniel Lapsley, Katheryn Kelley Jun 2022

On The Catholic Identity Of Students And Schools: Value Propositions For Catholic Education, Daniel Lapsley, Katheryn Kelley

Journal of Catholic Education

The Catholic school sector is under significant stress with declining enrollments and schools closing in virtually every diocese in the United States. This paper examines two value propositions for Catholic education. One is its role in providing foundational support for the development of personal spiritual identity in emerging adulthood and across the lifecourse. The second is the contribution of Catholic education to moral-character formation. Both propositions are relatively underdeveloped. The question of students’ personal spiritual identity is overshadowed by the understandable concern with the Catholic identity of schools. The question of moral-character formation is subsumed by catechesis and liturgy but …


On The Roles Of Trait Anxiety And Toll Like Receptor 4 In Amphetamine Sensitization In Adolescent Male Rats, Corey A. Calhoun May 2022

On The Roles Of Trait Anxiety And Toll Like Receptor 4 In Amphetamine Sensitization In Adolescent Male Rats, Corey A. Calhoun

Graduate Doctoral Dissertations

Mammalian adolescence can be a difficult transition from childhood to adulthood, where increases in impulsivity and novelty- and risk-seeking are combined with heightened affect and elevated sensitivity to stress. Indeed, during adolescence, first drug use patterns emerge and in the continental United States, increasing misuse of amphetamines has been observed in adolescent youth. Myriad neural mechanisms underlie this shift in adolescence, including the dynamic remodeling of the mesocorticolimbic (MCL) pathway. Repeated drug administration affects neuroimmune substrates within the MCL circuit including toll-like receptor 4 (TLR4)Advances in addiction neuroscience indicate that drugs of abuse activate neural TLR4 and implicate glial TLR4 …