Striatal Activity Is Associated With Deficits Of Cognitive Control And Aberrant Salience For Patients With Schizophrenia, Alan E. Ceaser

Arts & Sciences Electronic Theses and Dissertations

A recent study has shown that the locus of the largest known dopamine abnormality between patients with schizophrenia and healthy controls is in the associative striatum (Kegeles et al., 2010). This dopamine abnormality in the associative striatum is thought to bring about aberrant salience assignment for patients, which may underlie symptoms of psychosis like delusions and hallucinations (Howes & Kapur, 2009). Interestingly, the associative striatum has segregated, looped, connectivity with cortical regions including the prefrontal and parietal cortices (Draganski et al., 2008; Redgrave, Vautrelle, & Reynolds, 2011) and computational models have suggested that it may function as an information gate …

Naturalistic Paradigms For Neuroimaging And Bedside Measures Of Conscious Awareness, Leah J. Sinai

Electronic Thesis and Dissertation Repository

Complex, naturalistic stimuli can test for covert awareness in behaviourally non-responsive patients. For patients with poor visual function, this thesis aimed to identify an auditory-only stimulus that could evaluate executive function. Also, it assessed if Galvanic Skin Response could be a suitable bedside testing method. Healthy individuals listened to 4 auditory stimuli in the fMRI scanner. During Galvanic Skin Response recording, an independent group of controls listened to an audio narrative and watched a movie. Behaviourally non-responsive patients were also tested during movie viewing. Using fMRI, an audio narrative was identified that produced widespread brain synchronization between healthy participants, critically …

Interactions Between The Basolateral Amygdala And Ventral Striatum During Probabilistic Learning In Children And Associations With Individual Differences In Free Cortisol, Haley J. Fallowfield

Electronic Thesis and Dissertation Repository

Stress can drastically alter the behavioural and functional correlates of feedback learning; however, the functional correlates of these effects are poorly understood, particularly in children. In the present study, typically developing children between the ages of 9- and 11-years-old completed a probabilistic learning task with both appetitive and aversive outcomes in a magnetic resonance imaging scanner. Anticipatory stress to the experimental environment was measured via salivary cortisol at baseline and prior to completion of the task. Although baseline and pre-MRI cortisol values were not reliably different at the group level, subsequent analyses revealed that the basolateral amygdala was less responsive …

Neural Correlates Of Rumination In Posttraumatic Stress Disorder Before And After Cognitive Processing Therapy, Katherine Ruth Buchholz

Dissertations

The utilization of functional magnetic resonance imaging (fMRI) techniques to examine biomarkers and neural activity patterns related to posttraumatic stress disorder (PTSD) has provided a way to investigate mechanisms that underlie the development, maintenance, and recovery from PTSD. Studying the neural correlates of individual differences related to transdiagnostic factors has the potential to provide clinically relevant information beyond that of diagnostic categories. Rumination is one such factor. Rumination, defined as repetitive, negative, self-focused thinking is considered to be a transdiagnostic factor that is associated with depression, anxiety, and PTSD. In individuals with PTSD, rumination serves as a cognitive avoidance factor …

Affectivity, Brain Structure And Function, And Treatment Outcomes In Cognitive Processing Therapy For Posttraumatic Stress Disorder, Wilson James Brown

Dissertations

Cognitive Processing Therapy (CPT) has been empirically validated as an efficacious treatment for Posttraumatic Stress Disorder (PTSD) (Resick, Nishith, Weaver, Astin, & Feuer, 2002; Cloitre, 2009). However, a deficiency of affect regulation skills may act as a barrier to the successful implementation of CPT in some cases, as CPT does not contain a module that directly addresses affectivity. The current study examined the relationship between affectivity and CPT by utilizing neuroimaging methodology to assess brain regions consistent with an affect regulation model of PTSD. Thirty-eight female interpersonal trauma survivors with PTSD received CPT, participating in assessment and scanning sessions at …

Multidimensional Frequency Domain Analysis Of Full-Volume Fmri Reveals Significant Effects Of Age, Gender, And Mental Illness On The Spatiotemporal Organization Of Resting-State Brain Activity, Robyn L. Miller, Erik B. Erhardt, Oktay Agcaoglu, Elena A. Allen, Andrew M. Michael, Jessica Turner, Juan Bustillo, Judith M. Ford, Daniel H. Mathalon, Theo G. M. Van Erp, Steven G. Potkin, Adrian Preda, Godfrey Pearlson, Vince D. Calhoun

Psychology Faculty Publications

Clinical research employing functional magnetic resonance imaging (fMRI) is often conducted within the connectionist paradigm, focusing on patterns of connectivity between voxels, regions of interest (ROIs) or spatially distributed functional networks. Connectivity-based analyses are concerned with pairwise correlations of the temporal activation associated with restrictions of the whole-brain hemodynamic signal to locations of a priori interest. There is a more abstract question however that such spatially granular correlation-based approaches do not elucidate: Are the broad spatiotemporal organizing principles of brains in certain populations distinguishable from those of others? Global patterns (in space and time) of hemodynamic activation are rarely scrutinized …

Exploring The Effects Of Depression And Physical Activity On Pattern Separation Performance, Michelle I. Nash

Theses and Dissertations

Cognitive performance declines in depression and increases with physical activity. These changes may in part be due to changes in the level of neurogenesis (the generation and survival of adult-born neurons), which decreases with depression and increases with physical activity. Pattern separation (the formation of distinct neural representations of incoming information through orthogonalizing similar patterns of activation) has also been linked to neurogenesis. This project explores pattern separation within these two populations through three experiments.Experiment 1. Previous research has found impaired pattern separation among individuals with higher depression scores, but who have not been diagnosed with Major Depressive Disorder (MDD). …

Are There Multiple Kinds Of Episodic Memory? An Fmri Investigation Comparing Autobiographical And Recognition Memory Tasks, Hung-Yu Chen

Arts & Sciences Electronic Theses and Dissertations

What brain regions underlie retrieval from episodic memory? The bulk of research addressing this question has relied upon laboratory-based recognition memory. Another, less dominant tradition has employed autobiographical methods, whereby people recall events from their lifetime, often after being cued with words or pictures. Previous research comparing regions underlying successful memory retrieval between these two methodological approaches has shown mixed results. To examine the neural processes underlying recognition memory for materials encountered in the laboratory and autobiographical memory, we conducted a within-subject study using fMRI. We showed participants indoor and outdoor scenes under two types of instructions: In the lab-based …

Genetic Risk For Alzheimer's Disease Alters The Five-Year Trajectory Of Semantic Memory Activation In Cognitively Intact Elders, Stephen M. Rao, Aaron Bonner-Jackson, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, John L. Woodard, Sally Durgerian

Psychology Faculty Research and Publications

Healthy aging is associated with cognitive declines typically accompanied by increased task-related brain activity in comparison to younger counterparts. The Scaffolding Theory of Aging and Cognition (STAC) (Park and Reuter-Lorenz, 2009; Reuter-Lorenz and Park, 2014) posits that compensatory brain processes are responsible for maintaining normal cognitive performance in older adults, despite accumulation of aging-related neural damage. Cross-sectional studies indicate that cognitively intact elders at genetic risk for Alzheimer's disease (AD) demonstrate patterns of increased brain activity compared to low risk elders, suggesting that compensation represents an early response to AD-associated pathology. Whether this compensatory response persists or declines with the …

Location, Location, Location: Alterations In The Functional Topography Of Face- But Not Object- Or Place-Related Cortex In Adolescents With Autism, K. Suzanne Scherf, Beatriz Luna, Nancy Minshew, Marlene Behrmann

Marlene Behrmann

In autism, impairments in face processing are a relatively recent discovery, but have quickly become a widely accepted aspect of the behavioral profile. Only a handful of studies have investigated potential atypicalities in autism in the development of the neural substrates mediating face processing. High-functioning individuals with autism (HFA) and matched typically developing (TD) controls watched dynamic movie vignettes of faces, common objects, buildings, and scenes of navigation while undergoing an fMRI scan. With these data, we mapped the functional topography of category-selective activation for faces bilaterally in the fusiform gyrus, occipital face area, and posterior superior temporal sulcus. Additionally, …

Cortical Patterns Of Category-Selective Activation For Faces, Places And Objects In Adults With Autism, Kate Humphreys, Uri Hasson, Galia Avidan, Nancy Minshew, Marlene Behrmann

Marlene Behrmann

Autism is associated with widespread atypicalities in perception, cognition and social behavior. A crucial question concerns how these atypicalities are reflected in the underlying brain activation. One way to examine possible perturbations of cortical organization in autism is to analyze the activation of category-selective ventral visual cortex, already clearly delineated in typical populations. We mapped out the neural correlates of face, place and common object processing, using functional magnetic resonance imaging (fMRI), in a group of high-functioning adults with autism and a typical comparison group, under both controlled and more naturalistic, viewing conditions. There were no consistent group differences in …

The Neural Basis Of Visual Word Form Processing: A Multivariate Investigation, Adrian Nestor, Marlene Behrmann, David Plaut

Marlene Behrmann

Current research on the neurobiological bases of reading points to the privileged role of a ventral cortical network in visual word processing. However, the properties of this network and, in particular, its selectivity for orthographic stimuli such as words and pseudowords remain topics of significant debate. Here, we approached this issue from a novel perspective by applying pattern-based analyses to functional magnetic resonance imaging data. Specifically, we examined whether, where and how, orthographic stimuli elicit distinct patterns of activation in the human cortex. First, at the category level, multivariate mapping found extensive sensitivity throughout the ventral cortex for words relative …

‘‘What’’ Precedes ‘‘Which’’: Developmental Neural Tuning In Face- And Place-Related Cortex, K. Suzanne Scherf, Beatriz Luna, Galia Avidan, Marlene Behrmann

Marlene Behrmann

Although category-specific activation for faces in the ventral visual pathway appears adult-like in adolescence, recognition abilities for individual faces are still immature. We investigated how the ability to represent “individual” faces and houses develops at the neural level. Category-selective regions of interest (ROIs) for faces in the fusiform gyrus (FG) and for places in the parahippocampal place area (PPA) were identified individually in children, adolescents, and adults. Then, using an functional magnetic resonance imaging adaptation paradigm, we measured category selectivity and individual-level adaptation for faces and houses in each ROI. Only adults exhibited both category selectivity and individual-level adaptation bilaterally …

Emerging Structure–Function Relations In The Developing Face Processing System, K. Suzanne Scherf, Cibu Thomas, Jamie Doyle, Marlene Behrmann

Marlene Behrmann

To evaluate emerging structure–function relations in a neural circuit that mediates complex behavior, we investigated age-related differences among cortical regions that support face recognition behavior and the fiber tracts through which they transmit and receive signals using functional neuroimaging and diffusion tensor imaging. In a large sample of human participants (aged 6–23 years), we derived the microstructural and volumetric properties of the inferior longitudinal fasciculus (ILF), the inferior fronto-occipital fasciculus, and control tracts, using independently defined anatomical markers. We also determined the functional characteristics of core face- and place-selective regions that are distributed along the trajectory of the pathways of …

Neural Correlates Of Episodic Memory Formation In Children And Adults, Lingfei Tang

Wayne State University Theses

The medial temporal lobe (MTL) and prefrontal cortex (PFC) are two key brain regions that support episodic memory formation in both children and adults, but the functional developmental of these regions remains unclear. In this study, we investigated the development of neural correlates of episodic memory formation using functional MRI with a subsequent memory paradigm, administered to a cross-sectional sample of 83 children and adults. We found that MTL subregions showed an age-related increase in activation supporting memory formation of complex scenes. In addition, a functionally defined scene-sensitive region in the posterior MTL also showed similar increase and predicted better …

Scent Of The Familiar: An Fmri Study Of Canine Brain Responses To Familiar And Unfamiliar Human And Dog Odors, Gregory S. Berns, Andrew M. Brooks, Mark Spivak

Social Cognition Collection

Understanding dogs’ perceptual experience of both conspecifics and humans is important to understand how dogs evolved and the nature of their relationships with humans and other dogs. Olfaction is believed to be dogs’ most powerful and perhaps important sense and an obvious place to begin for the study of social cognition of conspecifics and humans. We used fMRI in a cohort of dogs (N = 12) that had been trained to remain motionless while unsedated and unrestrained in the MRI. By presenting scents from humans and conspecifics, we aimed to identify the dimensions of dogs’ responses to salient biological …

The Rewarding Nature Of Anger Rumination In Borderline Personality Disorder: An Fmri Investigation, Jessica R. Peters

Theses and Dissertations--Psychology

Anger rumination, or persistently dwelling on feelings of anger, is associated with borderline personality disorder (BPD) and related features, such as aggressive behavior and cognitive distortions. To develop more effective treatments, it is crucial to understand why individuals with BPD engage in anger rumination despite its negative outcomes. The activation of energy associated with anger, as well as feelings of justification and validation, may be experienced in the short-term as rewarding. This may prevent individuals with BPD from attempting to reduce their rumination.

Functional magnetic resonance imaging (fMRI) and behavioral methods were utilized to examine this theory in a sample …

Aberrant Functioning Of The Theory-Of-Mind Network In Children And Adolescents With Autism., Rajesh Kana, Jose Maximo, Diane Williams, Timothy Keller, Sarah Schipul, Vladimir Cherkassky, Nancy Minshew, Marcel Just

Marcel Adam Just