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Semantic Memory Activation In Amnestic Mild Cognitive Impairment, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, Piero Antuono, Leslie Guidotti, Sally Durgerian, Qi Zhang, Melissa A. Lancaster, Nathan Hantke, Alissa Butts, Stephen M. Rao

Psychology Faculty Research and Publications

Cognitively intact older individuals at risk for developing Alzheimer’s disease frequently show increased functional magnetic resonance imaging (fMRI) brain activation presumably associated with compensatory recruitment, whereas mild cognitive impairment (MCI) patients tend not to show increased activation presumably due to reduced neural reserve. Previous studies, however, have typically used episodic memory activation tasks, placing MCI participants at a performance disadvantage relative to healthy elders. In this event-related fMRI study, we employed a low effort, high accuracy semantic memory task to determine if increased activation of memory circuits is preserved in amnestic MCI when task performance is controlled. Fifty-seven participants, aged …