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Department of Psychology: Faculty Publications
Pavlovian conditioning; stimulant use disorder; Wellbutrin; Zyban
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Pavlovian Drug Discrimination With Bupropion As A Feature Positive Occasion Setter: Substitution By Methamphetamine And Nicotine, But Not Cocaine, Jamie L. Wilkinson, Chia Li, Rick A. Bevins
Pavlovian Drug Discrimination With Bupropion As A Feature Positive Occasion Setter: Substitution By Methamphetamine And Nicotine, But Not Cocaine, Jamie L. Wilkinson, Chia Li, Rick A. Bevins
Department of Psychology: Faculty Publications
Bupropion can serve as a discriminative stimulus (SD) in an operant drug discrimination task, and a variety of stimulants substitute for the bupropion SD. There are no reports, however, of bupropion functioning as a Pavlovian occasion setter (i.e., feature positive modulator). The present experiment seeks to fill this gap in the literature by training bupropion in rats as a feature positive modulator that disambiguates when a light will be paired with sucrose. Specifically, on bupropion (10 mg/kg IP) sessions, offset of 15-sec cue lights were followed by brief delivery of liquid sucrose; saline sessions were similar …