Open Access. Powered by Scholars. Published by Universities.®
Department of Psychology: Faculty Publications
Nicotine; nicotinic acetylcholine receptor antagonism; Pavlovian drug discrimination; mecamylamine; dihydro-β-erythroidine; dextromethorphan
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Mecamylamine, Dihydro-Β-Erythroidine, And Dextromethorphan Block Conditioned Responding Evoked By The Conditional Stimulus Effects Of Nicotine, Amanda M. Struthers, Jamie L. Wilkinson, Linda P. Dwoskin, Peter A. Crooks, Rick A. Bevins
Mecamylamine, Dihydro-Β-Erythroidine, And Dextromethorphan Block Conditioned Responding Evoked By The Conditional Stimulus Effects Of Nicotine, Amanda M. Struthers, Jamie L. Wilkinson, Linda P. Dwoskin, Peter A. Crooks, Rick A. Bevins
Department of Psychology: Faculty Publications
Current smokers express the desire to quit. However, the majority find it difficult to remain abstinent. As such, research efforts continually seek to develop more effective treatment. One such area of research involves the interoceptive stimulus effects of nicotine as either a discriminative stimulus in an operant drug discrimination task, or more recently as a conditional stimulus (CS) in a discriminated goal-tracking task. The present work investigated the potential role nicotinic acetylcholine receptors in the CS effects of nicotine (0.4 mg/kg) using antagonists with differential selectivity for β2*, α7*, α6β2*, and α3β4* receptors. Methyllycaconitine (MLA) had no effect on nicotine-evoked …