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Psychology

Theses/Dissertations

Memory

Theses and Dissertations

2015

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Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis May 2015

Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis

Theses and Dissertations

The consolidation of fear memories is known to depend on a number of critical cellular processes including de novo protein synthesis and 26S proteasome-dependent protein degradation following auditory fear conditioning (Jarome et al., 2011; Kwapis et al., 2011). Early work has suggested that protein degradation, mediated by the ubiquitin proteasome system (UPS), may regulate the requirement for de novo protein synthesis during memory consolidation (Jarome & Helmstetter, 2014). However, the precise way in which the UPS is able to regulate mechanisms of protein synthesis remain unclear. In the present set of experiments, we investigated the role of the protein phosphatase 2A ...


Exploration Of The Wechsler Memory Scale Fourth Edition And Measures Of Executive Function Combined Components Model, Isaac Tourgeman Jan 2015

Exploration Of The Wechsler Memory Scale Fourth Edition And Measures Of Executive Function Combined Components Model, Isaac Tourgeman

Theses and Dissertations

While memory is the faculty that affords us learning, adaptation and development, it is our executive function that oversees, manages and organizes these abilities. Still, there is limited research on the interaction between memory and executive function. The present study investigated this relationship through Principal Components Analysis. Performances on accepted measures of memory and executive function were evaluated in an adult clinical sample. Components were retained using three criteria: a predetermined four-component structure, eigenvalues exceeding a value of one, and parallel analysis. Results demonstrated that a four-component model most accurately represented the data. Analyses also revealed that measures of immediate ...