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Psychology

Theses/Dissertations

Memory

University of Iowa

2019

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The Neural Correlates And Temporal Dynamics Of Cued Fear Generalization, Kelsey Nicole Wilson Aug 2019

The Neural Correlates And Temporal Dynamics Of Cued Fear Generalization, Kelsey Nicole Wilson

Theses and Dissertations

Fear generalization, the generalization of fear to innocuous stimuli, is a characteristic component of pathological anxiety. For example, after returning from war, a person might begin to experience fear in response to the sound of fireworks, a stimulus typically regarded as safe. When excessive, “overgeneralization” serves as a core feature of fear and anxiety-related disorders, such as PTSD. The present collection of studies sought to investigate the neural correlates and temporal dynamics of fear generalization in humans.

The first study sought to investigate the causal role of the ventromedial prefrontal cortex (vmPFC) and hippocampus in the generalization of fear. Contrary ...