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Effects Of Pharmacological De-Prenylation Of Rhes On Motor Behavior In A Beta-Nitropropionic Acid Animal Model Of Huntington's Disease, Ashley Whitmarsh
Effects Of Pharmacological De-Prenylation Of Rhes On Motor Behavior In A Beta-Nitropropionic Acid Animal Model Of Huntington's Disease, Ashley Whitmarsh
University of New Orleans Theses and Dissertations
Huntington’s disease (HD) is a heritable, neurodegenerative disorder characterized by motor, cognitive, and psychiatric disturbances. The progressive disease is caused by an unstable CAG expansion within the gene that normally encodes for the huntingtin protein (Htt). The expanded mutant form of Htt (mHtt) is expressed ubiquitously throughout patients’ bodies; however, neuronal degeneration is prominent only in the corpus striatum and, to a lesser extent, the cortex. The Ras homolog Rhes is also preferentially localized to the striatum. The putative co-factor Rhes has been shown to act with mHtt to cause neuronal death. Simvastatin, a lipid lowering drug, and zoledronate, a …
The Effects Of Rhes, A Striatal Specific Protein, On The Expression Of Behavioral And Neuropathological Symptoms In A Transgenic Mouse Model Of Huntington's Disease, Brandon A. Baiamonte
The Effects Of Rhes, A Striatal Specific Protein, On The Expression Of Behavioral And Neuropathological Symptoms In A Transgenic Mouse Model Of Huntington's Disease, Brandon A. Baiamonte
University of New Orleans Theses and Dissertations
Huntington's disease (HD) is a neuropsychiatric disorder characterized by choreiform movement of the limbs, cognitive disability, psychosis and dementia. It is untreatable, incurable, and ultimately fatal. HD is invariably associated with an abnormally long CAG expansion within the IT15 gene on human chromosome 4. Although the mutant huntingtin protein (mHtt) is ubiquitously expressed in HD patients, cellular degeneration occurs only in neurons within the striatum and cerebral cortex. The Ras homolog Rhes is expressed very selectively in the precise brain areas affected by HD. Recent work using cultured cells suggests that Rhes may be a co-factor with mHtt in cell …