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Sticking To The Recipe: How Do Adherence And Differentiation To A Cbt Protocol Affect Client Outcomes In Youths With Anxiety?, Ruben G. Martinez Jan 2017

Sticking To The Recipe: How Do Adherence And Differentiation To A Cbt Protocol Affect Client Outcomes In Youths With Anxiety?, Ruben G. Martinez

Theses and Dissertations

Objective: Understanding the pathways through which treatments work to change symptom and diagnostic outcomes is important to the development and delivery of evidence-based treatments. This study assessed the extent to which adherence (therapist’s delivery of prescribed therapeutic interventions) and differentiation (therapist’s delivery of non-prescribed therapeutic interventions) to Coping Cat, a CBT program, affected client symptom and diagnostic outcomes. Method: The Therapy Process Observational Coding System for Child Psychotherapy – Revised Strategies Scale (McLeod et al., 2015) was used to characterize therapeutic interventions delivered within and outside of the Coping Cat program with youths aged 7-15 receiving treatment in one efficacy …


Predictors Of Vicarious Traumatization Among Trauma Clinicians And General Mental Health Providers: A Comparison, Shaina Gulin Jan 2017

Predictors Of Vicarious Traumatization Among Trauma Clinicians And General Mental Health Providers: A Comparison, Shaina Gulin

Theses and Dissertations

Vicarious traumatization (VT) describes the gradual, transformative shifts in internal experience that occur as a result of cumulative exposure to clients’ trauma material. VT is thought to develop in the therapist due to empathic engagement with clients, resulting in profound disruptions in frame of reference. Because VT is conceptualized as a condition that develops due to frequent exposure to clients’ traumatic material, a rapidly emerging body of theoretical literature suggests that clinicians can safeguard against VT by maintaining a more balanced workload (i.e., a caseload of clients with a variety of presenting problems) and limiting the number of trauma cases. …


Developing Conceptual Understanding And Procedural Fluency In Algebra For High School Students With Intellectual Disability, Andrew J. Wojcik Jan 2017

Developing Conceptual Understanding And Procedural Fluency In Algebra For High School Students With Intellectual Disability, Andrew J. Wojcik

Theses and Dissertations

Teaching students with Intellectual Disability (ID) is a relatively new endeavor. Beginning in 2001 with the passage of the No Child Left Behind Act, the general education curriculum integrated algebra across the K-12 curriculum (Kendall, 2011; National Governors Association Center for Best Practices & Council of Chief State School Officers, 2010), and expansion of the curriculum included five intertwined skills (productive disposition, procedural fluency, strategic competence, adaptive reasoning, and conceptual understanding) (Kilpatrick, Swafford, & Findell, 2001). Researchers are just beginning to explore the potential of students with ID with algebra (Browder, Spooner, Ahlgrim-Delzell, Harris & Wakeman, 2008; Creech-Galloway, Collins, Knight, …


Protective Factors In The Association Between Child Sexual Abuse And Telomere Length In Adults, David Sosnowski Jan 2017

Protective Factors In The Association Between Child Sexual Abuse And Telomere Length In Adults, David Sosnowski

Theses and Dissertations

The purpose of the present study was to examine if childhood sexual abuse (CSA) was associated with decreases in mean telomere length (TL), and if social support and/or optimism moderated this association. The study included 99 Caucasian female monozygotic twins, ranging in age from 19-48 (Mage = 30.5, SD = 7.8) at Time 1. Linear mixed effects models were employed to test study hypotheses. Analyses with all participants did not detect an effect of CSA exposure or severity on mean TL, nor were there effects with optimism. However, in analyses that only included women exposed to abuse, increases …


Three Measures Of Coping In Video Games (Civ-Iii): The Development, Construct Validation, And Profile Analysis Of The Civ-Iii, Chelsea M. Hughes Jan 2017

Three Measures Of Coping In Video Games (Civ-Iii): The Development, Construct Validation, And Profile Analysis Of The Civ-Iii, Chelsea M. Hughes

Theses and Dissertations

Video games provide a competitive, goal-oriented environment. They involve individuals who often seek intentionally to frustrate their opponents’ goals. The gaming community is made up of players who vary in their interpersonal style, learning histories, and skill levels. In this rich and dynamic environment, stress is a common experience. Given the prevalence of gameplay in the population and the frequency of gameplay among gamers, it is important to examine coping responses to stressors, particularly maladaptive ones. The present research entails three studies. In Study 1, I use exploratory factor analyses to develop three scales purported to measure maladaptive coping strategies …


The Role Of Mindfulness In The Regulation Of Behavior Among Those Prone To Negative Urgency, Alexandra M. Martelli Jan 2017

The Role Of Mindfulness In The Regulation Of Behavior Among Those Prone To Negative Urgency, Alexandra M. Martelli

Theses and Dissertations

Negative emotions can be challenging to regulate, and for some individuals can lead to failures of behavior regulation. The present study is an initial effort to explore the role that mindfulness may play in fostering effective behavior regulation among those prone to high negative urgency (NU). Eighty undergraduate students were recruited based on their high or low scores of NU. First, participants completed a self-report measure of mindfulness (Mindful Attention Awareness Scale; MAAS), an Emotional Go/No Go task in an fMRI scanner, and then reported alcohol consumption. Results showed that those with high in NU had low levels of mindfulness …


Self-Forgiveness In Romantic Relationships: The Impact On The Perpetrator And The Relationship, Jaclyn M. Moloney Jan 2017

Self-Forgiveness In Romantic Relationships: The Impact On The Perpetrator And The Relationship, Jaclyn M. Moloney

Theses and Dissertations

Two studies were conducted to determine how self-forgiveness and other perpetrator reactions influence the perpetrator and the victim after a romantic relationship transgression. Study 1 used a longitudinal design to determine how guilt and shame predicted the trajectory of self-forgiveness, self-excusing, and self-punishing in participants who had recently been the perpetrator of a romantic relationship transgression.

Those experiencing higher guilt at baseline had higher self-forgiveness starting out and those lower on guilt starting out had a greater change in self-forgiveness. Those experiencing more guilt at baseline experienced less change in self-forgiveness over time. Shame was not significantly related to self-forgiveness …


The Development Of The Therapy Process Observational Coding System - In-Session Involvement, Emily J. Wheat Jan 2017

The Development Of The Therapy Process Observational Coding System - In-Session Involvement, Emily J. Wheat

Theses and Dissertations

In-session client involvement (i.e., participation in in-session therapeutic tasks) is hypothesized to be a necessary component of youth therapy and associated with positive outcomes. However, research on in-session client involvement has been slowed by definitional problems. At present, the field has not yet adopted a single definition of client involvement that is applicable across different theoretical orientations, which has impacted the measurement of this construct. To remedy this problem, the field needs to adopt a definition of in-session client involvement that includes important components (i.e., behavioral, affective, and cognitive) of this construct that applies across different theoretical orientations and use …


Longitudinal Bidirectional Relations Between Subtypes Of Anxiety And Callous-Unemotional Traits In Early- To Mid-Adolescence, Stephanie A. Hitti Jan 2017

Longitudinal Bidirectional Relations Between Subtypes Of Anxiety And Callous-Unemotional Traits In Early- To Mid-Adolescence, Stephanie A. Hitti

Theses and Dissertations

Callous-Unemotional (CU) traits are characterized by limited empathy, lack of guilt or remorse, and callous use of others. They are a risk factor for adult psychopathy, especially when comorbid with conduct problems. Thus, efforts to identify risk factors and consequences of CU traits have been prominent. One construct that may act as both a risk factor for and consequence of CU traits among youth is anxiety. While the most consistent finding is in this literature is a negative relation between CU traits and anxiety, findings have been mixed. The present study examined bidirectional relations between three subtypes of anxiety (i.e. …


Integrating Genetics And Neuroimaging To Study Subtypes Of Binge Drinkers, Megan E. Cooke Jan 2017

Integrating Genetics And Neuroimaging To Study Subtypes Of Binge Drinkers, Megan E. Cooke

Theses and Dissertations

Risky alcohol use is a major health concern among college students, with 40.1% reporting binge drinking (5 or more drinks in one occasion) and 14.4% reporting heavy drinking (binge drinking on 5 or more occasions) in the past month. Risky alcohol use is thought to be the result of a complex interplay between genes, biological processes, and other phenotypic characteristics. Understanding this complex relationship is further complicated by known phenotypic heterogeneity in the development of alcohol use. Developmental studies have suggested two pathways to risky alcohol use, characterized by externalizing and internalizing characteristics, respectively. However, the underlying biological processes that …


Recovery From Design, Cassandra J. Ellison Jan 2017

Recovery From Design, Cassandra J. Ellison

Theses and Dissertations

Through research, inquiry, and an evaluation of Recovery By Design, a ‘design therapy’ program that serves people with mental illness, substance use disorders, and developmental disabilities, it is my assertion that the practice of design has therapeutic potential and can aid in the process of recovery. To the novice, the practices of conception, shaping form, and praxis have empowering benefit especially when guided by Conditional and Transformation Design methods together with an emphasis on materiality and vernacular form.


Taken Back By The Ballpark: The Role Of Nostalgia In The Minor League Baseball Spectator Experience, Mark A. Slavich Jan 2017

Taken Back By The Ballpark: The Role Of Nostalgia In The Minor League Baseball Spectator Experience, Mark A. Slavich

Theses and Dissertations

The use of nostalgia has become a feature in baseball ballparks in recent years, with research showcasing the prevalence of nostalgic stimuli including bricks, steel beams, and old-fashioned scoreboards popular in the past. The impact of such stimuli on spectators’ emotions and behavior had yet to be explored, though. Therefore, the purpose of the current study was to investigate the impact of nostalgia on minor league baseball spectator emotional and behavioral responses.

Data collection occurred at three minor league baseball games during June 2017. Utilizing the SOR framework (Mehrabian & Russell, 1974) as the theoretical foundation, a 39-item instrument was …


What's The 411 On Sex In The African American Church? A Qualitative Exploration Of African American Girls' Exposure To Sex Communication In The Church., Brittany Berry Jan 2017

What's The 411 On Sex In The African American Church? A Qualitative Exploration Of African American Girls' Exposure To Sex Communication In The Church., Brittany Berry

Theses and Dissertations

WHAT’S THE 411 ON SEX IN THE AFRICAN AMERICAN CHURCH? A QUALITATIVE EXPLORATION OF AFRICAN AMERICAN GIRLS’ EXPOSURE TO SEX COMMUNICATION IN THE CHURCH

By: Brittany M. Berry, Ph.D.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2017.

Major Director: Dr. Faye Z. Belgrave, Professor, Psychology

The purpose of this dissertation research was to explore sex communication with African American girls in the African American Church. This research was guided by two objectives: (1) to explore African American adolescent girls’ exposure to sex communication in …


Non-Medical Use Of Prescription Drugs, Stress, Cultural Orientation, Utilization Of Healthcare, And Protective Factors Among College Students In China, Cheuk Chi Tam Jan 2017

Non-Medical Use Of Prescription Drugs, Stress, Cultural Orientation, Utilization Of Healthcare, And Protective Factors Among College Students In China, Cheuk Chi Tam

Theses and Dissertations

Background: Non-medical use of prescription drugs (NMUPD) refers to the use of prescription drugs which are traditionally utilized to manage pain or treat psychiatric problems but without a doctor’s prescription. In 2010, an investigation by the Substance Use and Mental Health Services Administration (SAMHSA) revealed that 5.3% of young adults (18 to 25-year-olds) in the United States reported past-month NMUPD. NMUPD has become a growing concern owing to associations with consequences such as college dropout, poor academic achievement, and health jeopardizing behaviors. College students' NMUPD has been well documented in the United States. Limited studies, however, have been conducted among …


Parent-Fostered Enrichment Activities And Academic Outcomes In Middle Childhood, Princess-Melissa T. Washington-Nortey Jan 2017

Parent-Fostered Enrichment Activities And Academic Outcomes In Middle Childhood, Princess-Melissa T. Washington-Nortey

Theses and Dissertations

Despite numerous educational reforms, elementary school children in the United States continue to lag behind their peers from other developed countries on reading, math and science outcomes. Many interventions focus on strategies aimed at increasing the amount of classroom work children undertake. However, the key to improving outcomes may lie in out of school enrichment activities that facilitate learning. Drawing from Eccles Expectancy-Value theory(Simpkins, Fredricks, & Eccles, 2012), the current study focuses on assessing the impact of parent-fostered enrichment activities on child academic outcomes in the first three years of elementary school. Using secondary data from Early Childhood Longitudinal Study …


Ethnic Racial Identity, Social Transactions In The Classroom, And Academic Outcomes, Krystal R. Thomas Jan 2017

Ethnic Racial Identity, Social Transactions In The Classroom, And Academic Outcomes, Krystal R. Thomas

Theses and Dissertations

Using a transactional framework, this study explored social relationships in the classroom as mediators of the association between ethnic-racial identity and academic outcomes. Participants were 101 5th graders of diverse backgrounds who completed computer-based questionnaires about their friendships, ethnic-racial identity, and academic engagement. Teachers reported on closeness and conflict in the student-teacher relationship. Relationships in the expected direction were evident between the public regard and centrality dimensions of ethnic-racial identity and social relationships as well as with academic outcomes. Further, path analyses revealed that the relationship between the public regard and cognitive engagement was mediated by student-teacher closeness. Gender …


Effects Of Cumulative Risk On Asthma Outcomes In Urban Children And Adolescents, Samantha A. Miadich Jan 2017

Effects Of Cumulative Risk On Asthma Outcomes In Urban Children And Adolescents, Samantha A. Miadich

Theses and Dissertations

Pediatric asthma disproportionately affects racial/ethnic minority children and children living in low-income, urban areas. Many families living in low-income, urban areas experience a number of stressors that can place children/adolescents at risk for worse asthma outcomes. This study examined the impact of a cumulative risk model of stressors (e.g., ED visits, quick-relief medication use, lung function, asthma control, QOL) in urban children (7-12 years) with persistent asthma. This study further aimed to examine both the original cumulative risk model and an adolescent-specific cumulative risk model as predictors of asthma outcomes in a sample of 60 adolescents (13-17 years). Asthma-related caregiver …


The Mediating Role Of Mental Health In The Relationship Between Discrimination And Risky Behaviors In Lgbt Adults In Latin America, Annie Rabinovitch Jan 2017

The Mediating Role Of Mental Health In The Relationship Between Discrimination And Risky Behaviors In Lgbt Adults In Latin America, Annie Rabinovitch

Theses and Dissertations

The study explored relationships among discrimination experiences, mental health (i.e., anxiety symptoms, depression symptoms), risky behaviors (i.e., suicidal ideation, illicit substance use), religiosity, and social support in LGBT adults residing in Latin America. First, multiple regression analyses were conducted to identify patterns of connections among discrimination, mental health, suicidal ideation, and illicit substance use in sexual and gender minority adults from Latin American. Harassment/Rejection discrimination, but neither Work/School nor Other discrimination predicted suicidal ideation. None of the three discrimination subscales predicted illicit substance use. Work/School discrimination predicted mental health problems (Anxiety and Depression subscales of HSCL-25 combined), while Harassment/Rejection and …


A Hierarchical Linear Modeling Approach To Predicting Trajectories Of Posttraumatic Growth In Veterans Following Acquired Physical Disability, Lisa Goldberg Looney Jan 2017

A Hierarchical Linear Modeling Approach To Predicting Trajectories Of Posttraumatic Growth In Veterans Following Acquired Physical Disability, Lisa Goldberg Looney

Theses and Dissertations

The purpose of this study was to examine potential predictors of PTG across time in Veterans with acquired physical disabilities. Specifically, this study aimed to understand how various demographic and injury characteristics, coping styles, appraisals of injury, and social support might predict trajectories of PTG from discharge from inpatient rehabilitation through 12 months after baseline. Initial curvature analyses suggested that a cubic polynomial trend best fit the movement of PTG over time, generally conforming to an initial increase, decrease, and then plateau or slight increase. Four HLMs were run to examine whether demographic and injury characteristics, coping styles, appraisals of …


Building A Bond: Longitudinal Relations Between Interpersonal School Climate, Student Awareness And Reporting Of Violence, And Peer Victimization And Aggression In Adolescents, Kathryn Behrhorst Jan 2017

Building A Bond: Longitudinal Relations Between Interpersonal School Climate, Student Awareness And Reporting Of Violence, And Peer Victimization And Aggression In Adolescents, Kathryn Behrhorst

Theses and Dissertations

High prevalence rates and negative outcomes of peer-based aggression and victimization during early adolescence underscore the need to identify causes and consequences of these outcomes. Limited research has examined the impact of environmental and contextual factors, such as school climate, on peer aggression and victimization. Few studies have addressed relations between school climate and specific subtypes of physical and relational aggression and victimization. Although school climate has been assessed via interpersonal subsystems (i.e., student-student and student-teacher relationships), little research has incorporated the role of student awareness and reporting of violence and safety concerns. Further, studies are needed that consider the …


An Integrated Behavioral Model Of Healthcare Utilization Among Transgender And Gender-Nonconforming Adults, Megan Elizabeth Sutter Jan 2017

An Integrated Behavioral Model Of Healthcare Utilization Among Transgender And Gender-Nonconforming Adults, Megan Elizabeth Sutter

Theses and Dissertations

Transgender and gender-nonconforming (TGNC) individuals in the United States experience significant marginalization due to stigma enacted at the structural, interpersonal, and individual levels. As a result, this population has reported increased behavioral and physical health needs, as well as unique barriers to healthcare. Moreover, TGNC individuals have reported greater experiences of childhood abuse compared to cisgender individuals. The cumulative experiences of stigma-related stressors and adverse childhood experiences put this population at risk for the development of mental and physical health problems, increasing need for health services. However, TGNC individuals have reported being denied medical care and postponing seeking care due …


Synchrony And Concordance: A Multilevel Analysis Of The Effects Of Individual Differences During A Co2 Challenge, Rachel E. Wallace Jan 2017

Synchrony And Concordance: A Multilevel Analysis Of The Effects Of Individual Differences During A Co2 Challenge, Rachel E. Wallace

Theses and Dissertations

Emotion theories posit that emotion systems (e.g., behavior, self-report, physiology) should be related when an emotion is being elicited because this serves an adaptive purpose and allows the individual to respond appropriately to the present situation. Oftentimes, this coherent relationship is not found, and research has hypothesized that the type of analyses used and lack of examination of individual differences could be affecting this relationship. Most studies examine the relationship between emotion systems between-subjects when within-subjects analyses may be more appropriate. The present study examined the relationship between self-reported distress (SUDS) and heart rate, and whether trait differences of anxiety …


Mechanisms Of Motivational Interviewing In A Parent-Focused Pediatric Obesity Intervention, Nadia Islam Jan 2017

Mechanisms Of Motivational Interviewing In A Parent-Focused Pediatric Obesity Intervention, Nadia Islam

Theses and Dissertations

Pediatric obesity is a major public health epidemic with serious physical and psychological consequences. Difficulty engaging families in treatment is a significant obstacle in addressing pediatric obesity, especially among underserved populations. Motivational interviewing (MI) is a collaborative, person-centered communication style that has been shown to reduce attrition, increase attendance, and improve patient treatment adherence; however, little is known about the process of MI and how it improves treatment engagement. This study examined clinician and parent language in a pre-treatment MI session that increased initial engagement in a parent- focused pediatric obesity intervention (N= 81). Results showed that increased parent change …


Pathways Linking Clinician Demographics To Mental Health Diagnostic Accuracy: An International Perspective, Julia Brechbiel Jan 2017

Pathways Linking Clinician Demographics To Mental Health Diagnostic Accuracy: An International Perspective, Julia Brechbiel

Theses and Dissertations

Significant research efforts have focused on examining the effect of patient factors on providing diagnoses across clinical settings; however, the influence of clinician demographics have received less attention. This study aimed to understand the impact of nonclinical factors such as clinician characteristics and response time on diagnostic accuracy. The study used data from a WHO field study of the ICD-11 development (n = 1822) that required clinicians to diagnose two case vignettes. Clinicians’ slower response times had a significant positive impact on their rates of diagnostic accuracy. However, there was no evidence that clinicians’ demographic features were directly related to …


Modeling Psychologists’ Openness To Performing Clinical Work With Telepsychology, Bradford S. Pierce Jan 2017

Modeling Psychologists’ Openness To Performing Clinical Work With Telepsychology, Bradford S. Pierce

Theses and Dissertations

This cross-sectional study examined whether the Theory of Reasoned Action (TRA) and Technology Acceptance Model (TAM) apply to psychologists’ openness to using telepsychology, and to identify significant personal or environmental predictors of telepsychology adoption. A total of 1,791 licensed psychologists currently practicing psychotherapy in the United States were recruited to complete a previously developed 21-item pool. Personal and environmental characteristics were also collected. Path models representing the TRA, TAM, and a hybrid of both were tested. Also, a logistic regression was used to identify personal and environmental predictors of current use of telepsychology. Results indicated the TRA and TAM were …


The Influence Of Family Composition On Adolescent Problem Behavior: The Moderating Roles Of Gender And Adult Support, Jasmine Coleman Jan 2017

The Influence Of Family Composition On Adolescent Problem Behavior: The Moderating Roles Of Gender And Adult Support, Jasmine Coleman

Theses and Dissertations

There is convincing support for the link between family composition and adolescents’ problem behaviors. What is less clear is the extent to which these relations exist for African-American adolescents. Previous studies have demonstrated that this relation varies by gender. However, there is limited evidence to suggest the potential moderating influence of adult support. The purpose of this study was to examine the influence of family composition on adolescents’ physical aggression, delinquency, and substance use. The study comes from secondary analyses of a larger study that evaluated the effectiveness of a violence prevention program. The current study included 1,116 African-American middle …


Focused Attention Vs. Open Monitoring: An Event-Related Potential Study Of Emotion Regulation By Two Distinct Forms Of Mindfulness Meditation, Tarah L. Raldiris Jan 2017

Focused Attention Vs. Open Monitoring: An Event-Related Potential Study Of Emotion Regulation By Two Distinct Forms Of Mindfulness Meditation, Tarah L. Raldiris

Theses and Dissertations

This study investigated the effects of two novel forms of 8-week mindfulness meditation training, focused attention (FA) and open monitoring (OM), relative to an established training, mindfulness-based cognitive therapy (MBCT), on early emotional reactivity to negative emotional images as assessed by electroencephalography (EEG). Data on the late-positive potential (LPP) were analyzed to address whether the three mindfulness interventions attenuated the LPP from pre- to post-intervention, and if significant differences existed between groups in LPP at post-intervention. Rather than an attenuation, results indicated an average increase in LPP amplitude from pre- to post-intervention. No significant differences were found in the LPP …


Predictors Of Barriers To Psychosocial Treatment For African American Families Of Children With Adhd, Stephanie A. Wilson Jan 2017

Predictors Of Barriers To Psychosocial Treatment For African American Families Of Children With Adhd, Stephanie A. Wilson

Theses and Dissertations

African American families of youth with Attention-deficit/hyperactivity disorder (ADHD) traditionally have lower rates of ADHD treatment compared to nonminority groups. These treatment disparities underscore the importance of better understanding the barriers to treatment for these families. Therefore, in a sample of 67 African American caregivers of children with ADHD, the current study examined (1) factors that predict barriers to treatment for African American families of children with ADHD and (2) whether caregiver impairment mediates comorbid behavior problems and barriers to treatment for African American youth with ADHD. Analyses revealed that caregiver impairment predicted barriers to treatment and mediated the relationship …


Exploring The Role Of Motivational Interviewing In Adolescent Patient-Provider Communication About Type 1 Diabetes, Laura J. Caccavale Jan 2017

Exploring The Role Of Motivational Interviewing In Adolescent Patient-Provider Communication About Type 1 Diabetes, Laura J. Caccavale

Theses and Dissertations

Type 1 diabetes (T1D) is one of the most common pediatric chronic illnesses. Glycemic control among patients with T1D often deteriorates during adolescence; yet little is known about the most effective way for providers to communicate with adolescents to prevent this decline. Given the importance of effective communication, examination of effective patient-provider communication strategies is needed. The current investigation used Motivational Interviewing (MI) as a framework to help characterize naturally-occurring adolescent patient-provider communication in medical encounters and examined the relations between provider communication and T1D self-management and control.

Participants were five pediatric endocrine providers and 55 adolescents with T1D (49% …


Antidepressant-Like Effects Of Amisulpride, Ketamine, And Their Enantiomers On Differential-Reinforcement-Of-Low-Rate (Drl) Operant Responding In Male C57/Bl/6 Mice, Doug Smith Jan 2017

Antidepressant-Like Effects Of Amisulpride, Ketamine, And Their Enantiomers On Differential-Reinforcement-Of-Low-Rate (Drl) Operant Responding In Male C57/Bl/6 Mice, Doug Smith

Theses and Dissertations

Major depressive disorder (MDD) is a widespread psychiatric disorder that affects millions of people worldwide and is hypothesized to occur due to impairments in several neurotransmitter systems, including the monoaminergic and glutamatergic neurotransmitter systems. Antidepressant medications targeting multiple monoamine neurotransmitters have been shown to be effective for the treatment of depression. Racemic amisulpride is an atypical antipsychotic that has been used at low doses to treat dysthymia, a mild form of depression, and functions as an antagonist at DA2/3, 5-HT2B, and 5-HT7 receptors. Recent preclinical studies have suggested that the S(+) isomer may be more …