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Central Opioid Regulation Of Parental Behavior In Juvenile Rats, Jacquelyn C. Wellman
Central Opioid Regulation Of Parental Behavior In Juvenile Rats, Jacquelyn C. Wellman
Master's Theses
Morphine disrupts full parental behavior (FPB) in adult rats when administered into the preoptic area; effects are reversed with naloxone. The current study emphasizes central administration of morphine into the preoptic area and effects on parental behavior in juveniles and possible naloxone blockade. In Experiment 1, juveniles outfitted with cannulae assemblies aimed at the preoptic region were administered a regimen of morphine, naloxone, or saline, and 30 minutes later were exposed to neonates. Behavior was scored for 1 hour and animals were considered parental if they responded with FPB for 2 consecutive days. Saline and naloxone groups responded to the …
Morphine Disruption Of Maternal Behavior And Modifications Of Underlying Neural Activity, Graciela Stafisso-Sandoz
Morphine Disruption Of Maternal Behavior And Modifications Of Underlying Neural Activity, Graciela Stafisso-Sandoz
Master's Theses
Morphine significantly impairs maternal behavior; N aloxone, an opiate antagonist, restores it. Maternal behavior is associated with c-fos expression, an immediate early gene product, in medial preoptic area (mPOA) of females. In this series of experiments, the effects of morphine and Naloxone on the expression of c-fos were examined. On postpartum day 5 or 6, females were injected with morphine or saline ( Exp. 1 ), or morphine+Naloxone or morphine+saline (Exp. 2) and placed back in the homepage, separated from their pups by a wire-mesh partition. Sixty minutes later processing for cfos immunohistochemistry commenced. The c-fos positive cells in a …