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A Rat Model Of Sleep Deprivation Prior To Traumatic Brain Injury, Steve G. Soehnlen
A Rat Model Of Sleep Deprivation Prior To Traumatic Brain Injury, Steve G. Soehnlen
ETD Archive
Traumatic Brain Injury (TBI) has been called the "signature injury" of U.S. soldiers in Iraq and Afghanistan. Soldiers undergo a variety of stressors during their tours of duty that could complicate recovery from TBI, one of which is sleep deprivation (SD). In this study, we sought to create a rat model exploring the effects of prior REM sleep deprivation (RSD) on recovery from TBI-induced sensorimotor and cognitive deficits. Rats were deprived of REM sleep before they underwent a controlled cortical impact (CCI) to mimic a TBI. Forelimb sensorimotor function, hindlimb motor function, forelimb motor function, and spatial learning were assessed …
Recovery Of Sensorimotor Function In Rats Following Acute Rapid Eye Movement Sleep Deprivation And Controlled Cortical Impact, Jaime Lynn Shuster
Recovery Of Sensorimotor Function In Rats Following Acute Rapid Eye Movement Sleep Deprivation And Controlled Cortical Impact, Jaime Lynn Shuster
ETD Archive
Traumatic brain injury (TBI) resulting from bomb blasts and explosions is common among military personnel. The effects of Rapid Eye Movement (REM) sleep deprivation on the sensorimotor behavior and physiological mechanisms related to TBI are unknown. Thirty-two Long Evans rats were randomly assigned to REM sleep deprivation (RSD) with controlled cortical impact (CCI), social isolation (SI) with CCI, or normal housing (NH) with CCI or Sham. Two behavioral tasks [beam walk and bilateral tactile adhesive removal somatosensory (BTARS)] testing motor and sensory function were used to investigate recovery of function. Brain tissue was analyzed using Cresyl Violet stain (cell bodies), …
Combined Pharmacotherapy For The Treatment Of Traumatic Brain Injury Rehabilitation And Recovery Of Function Following Prefrontal Cortex Controlled Cortical Impact In Rats, Abby Nicole Kyser
Combined Pharmacotherapy For The Treatment Of Traumatic Brain Injury Rehabilitation And Recovery Of Function Following Prefrontal Cortex Controlled Cortical Impact In Rats, Abby Nicole Kyser
ETD Archive
Traumatic brain injury (TBI) is common among military personnel, resulting from bomb blasts and explosions. The secretion of pro-inflammatory cytokines following TBI has been linked to cerebral edema and neuronal loss. The use of lovastatin for TBI has been suggested to be neuroprotective by combating cytokines and inflammation. Fluoxetine has been suggested to aid in the prevention of edema during secondary injury processes, as well as having a relationship to neural plasticity. Seventy-six Long-Evans rats were randomly assigned to CCI (controlled cortical impact) or sham-operated as well as one of the following drug conditions: no treatment, vehicle, Fluoxetine only, Lovastatin …