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The Effects Of Progesterone Receptor On Development Of Serotonergic Circuits That Mediate Cognition, Heather Smith
The Effects Of Progesterone Receptor On Development Of Serotonergic Circuits That Mediate Cognition, Heather Smith
Psychology
As the rate of premature births has been substantially increasing, progestin administration is becoming a common treatment for the prevention of preterm labor. However, not much is known regarding how these hormonal supplements may affect the development of the fetal brain. The developing brain is highly sensitive to progesterone as progesterone receptor (PR) is expressed in many regions during critical developmental periods. Steroid hormone receptors such as PR are powerful transcription factors and regulate gene expression to alter fundamental processes of neural development. During the developmental period of post-natal day one (P1) to P14 in rats, PR is transiently expressed …
The Role Of Progesterone Receptor In Development Of Medial Prefrontal Cortex And Impulsive Behavior, Vanessa Costanzo
The Role Of Progesterone Receptor In Development Of Medial Prefrontal Cortex And Impulsive Behavior, Vanessa Costanzo
Psychology
Human behaviors are regulated by the complex functions of the brain and many behavioral disorders are assumed to be the result of alterations or deficits in neural function. Attention Deficit Hyperactivity Disorder (ADHD), characterized by differences in complex behaviors such as attention, memory and impulse control has been linked to alterations in dopaminergic activity in the medial prefrontal cortex (mPFC). Therefore, factors that regulate development of this region may be implicated in ADHD. For example, steroid hormones can alter fundamental processes of neural development through interaction with their nuclear receptors, which act as transcription factors. Progesterone receptor (PR) is transiently …
The Role Of The Progesterone Receptor In The Development Of The Ventromedial Nucleus And Female Sexual Behaviors, Keith L. Gonzales
The Role Of The Progesterone Receptor In The Development Of The Ventromedial Nucleus And Female Sexual Behaviors, Keith L. Gonzales
Legacy Theses & Dissertations (2009 - 2024)
Steroid induced gene transcription plays an important role in neural sex differences within many mammalian species. Steroid hormones actions within the developing brain have profound, permanent effects in the development of neurochemical processes and behaviors. Within the developing ventromedial nucleus of the hypothalamus (VMN), a potent transcription factor, the progesterone receptor (PR), is highly expressed within female rats. Furthermore, the regulation of PR within the developing VMN of the female rat is anatomically and developmentally specific. Typically, PR expression is highly dependent on the activity of estradiol acting at ERα. As such, circulating levels of estradiol act to induce PR …