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Longer Duration Of Epilepsy And Earlier Age At Epilepsy Onset Correlate With Impaired Cognitive Development In Infancy, Martina Vendrame
Longer Duration Of Epilepsy And Earlier Age At Epilepsy Onset Correlate With Impaired Cognitive Development In Infancy, Martina Vendrame
Scholarship and Professional Work - LAS
We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3 years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with epilepsy. Developmental quotients were calculated and were correlated with age at epilepsy onset, duration of epilepsy, seizure frequency, brain pathology, and types of seizures (with/without spasms) as potential predictors. Infants with longer duration and earlier onset of epilepsy performed worse on developmental neuropsychological testing. Regression analyses showed that age at epilepsy onset and percentage of life with epilepsy were …
Memory Performance Is Related To Language Dominance As Determined By The Intracarotid Amobarbital Procedure, S. Kovac, G. Möddel, J. Reinholz, A. V. Alexopoulosa, T. Syed, S. U. Schuele, Tara T. Lineweaver, T. Loddenkemper
Memory Performance Is Related To Language Dominance As Determined By The Intracarotid Amobarbital Procedure, S. Kovac, G. Möddel, J. Reinholz, A. V. Alexopoulosa, T. Syed, S. U. Schuele, Tara T. Lineweaver, T. Loddenkemper
Scholarship and Professional Work - LAS
Objective
The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.
Methods
In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other.
Results
Language lateralization and memory lateralization were positively correlated (r = 0.34, P < 0.01). Correlations differed depending on the presence and type of lesion (χ2 = 7.98, P < 0.05). LIs correlated significantly higher (z = 2.82, P < 0.05) in patients with cortical dysplasia (n = 41, r = 0.61, P < 0.01) compared with the group without lesions (n = 90, r = 0.16, P > 0.05), with patients with hippocampal sclerosis falling between these two groups. Both memory (P < 0.01) and language (P …
Atypical Language Lateralization In Epilepsy Patients, Gabriel Möddel, Tara T. Lineweaver, Stephan U. Schuele, Julia Reinholz, T. Loddenkemper
Atypical Language Lateralization In Epilepsy Patients, Gabriel Möddel, Tara T. Lineweaver, Stephan U. Schuele, Julia Reinholz, T. Loddenkemper
Scholarship and Professional Work - LAS
Purpose: To investigate whether atypical language dominance in epilepsy patients is related to localization and type of lesions.
Methods: Four hundred and forty-five epilepsy patients received bilateral Wada testing. Language was classified as left (L), right (R), bilateral-dependent (BD, speech arrest after left and right injections), or bilateral-independent (BI, no speech arrest after either injection). Groups were compared regarding handedness and magnetic resonance imaging (MRI) lesions. Lesions were classified as “early” (congenital), “late” neocortical (acquired after birth), and hippocampal sclerosis (HS).
Results: Of all patients, 78% were L, 6% R, 7% BD, and 9% BI. Right-handers with left lesions did …