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Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Graduate Theses, Dissertations, and Problem Reports
Traumatic brain injury (TBI) impacts millions worldwide and can cause lasting psychiatric symptoms. Chronic neuroinflammation is a characteristic of post-injury pathology and is positively associated with psychiatric conditions such as ADHD and bipolar disorder. Therefore, the current study sought to treat TBI-induced impulsivity and inattention using minocycline, an antibiotic with anti-inflammatory properties. Rats were trained on the five-choice serial reaction time task (5CSRT), a measure of motor impulsivity and attention. After behavior was stable on the 5CSRT, rats received either a bilateral frontal TBI or sham procedure. Minocycline was given at either 1 h post-injury or beginning at 8 weeks …
Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn
Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn
Graduate Theses, Dissertations, and Problem Reports
Traumatic Brain Injury (TBI) is defined as an impact to the head, penetration of the skull, or rapid deceleration of the skull, resulting in an alteration of brain function or neurological deficit. Cognitive deficits are common following TBI and often go unresolved due to a lack of effective treatments. These deficits often perseverate into the chronic post injury phase, so the development of rehabilitative strategies is imperative. Behavioral flexibility, impulse control, and attention are a few cognitive processes that are commonly affected by TBI. The current research compares these processes between rats with and without a severe frontal brain injury …