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Oprm1 Genotype Interacts With Serotonin System Dysfunction To Predict Alcohol-Heightened Aggression In Primates, Carlos A. Driscoll, Stephen G. Lindell, Melanie L. Schwandt, Stephen J. Suomi, J. Dee Higley, Markus Heilig, Christina S. Barr

Faculty Publications

Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhesus macaques under normal conditions and following alcohol administration. Prior studies have shown that a low CSF level of 5-HIAA is a trait marker for individuals prone to escalated aggression. We wanted to examine whether the predictive value for this marker on aggression was moderated by OPRM1 genotype. Animals were administered alcohol (BAC 100-200 mg%), were provoked …