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Cognitive And Emotional Abnormalities In People With Systemic Lupus Erythematosus, Philip Watson
Cognitive And Emotional Abnormalities In People With Systemic Lupus Erythematosus, Philip Watson
Dissertations, Theses, and Capstone Projects
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder characterized by the production of autoantibodies (ABs). Approximately 30-50% of patients produce ABs directed against N-Methyl-D-aspartic acid receptors (NMDARs). Previous research with animals has identified these ABs as being associated with amygdala damage and a deficit in fear conditioning. People with SLE can have damage to the amygdala. This study aimed to determine if emotional processing deficits occur in people with SLE and to associate such deficits, if they exist, with anti-NMDAR AB presence, length of disease, cognition, and mood. Fifty-eight (11 AB+, 24 AB-, 23 healthy) women participated in tasks …
Characterization Of Somatosensory Processing In Relation To Schizotypal Traits In A Sample Of Nonclinical Young Adults, Maureen Patricia Daly
Characterization Of Somatosensory Processing In Relation To Schizotypal Traits In A Sample Of Nonclinical Young Adults, Maureen Patricia Daly
Dissertations, Theses, and Capstone Projects
A core feature of schizophrenia spectrum disorders (SSDs) is a basic sensory (e.g., visual, auditory) processing disruption, yet few studies have examined somatosensation. The current dissertation project examined somatosensory processes among individuals at varying degrees of psychometric risk for psychosis using tactile texture and spatial discrimination and letter recognition tasks. Differential patterns of associations of somatosensory abilities with schizotypal trait dimensions (positive, negative, disorganized), independent of anxiety and depressive symptoms, and the relative contributions of bottom-up (peripheral and morphologic features) versus top-down (error types) processing were examined. It was hypothesized that: 1) performance on somatosensory tasks would account for significant …