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Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh
Electronic Thesis and Dissertation Repository
Exposure to stressful events during early development has consistently been shown to produce long lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may increase vulnerability to mood and anxiety disorders. Recently reported genetic association studies indicate that these disorders may be influenced, in part, by gene-environment interactions (GxE) involving polymorphisms within the corticotrophin-releasing hormone and monoaminergic system genes. However, little is known about how genetic variants and life stress work to shape children’s neuroendocrine reactivity and emerging symptoms. Therefore, the aim of this thesis is to examine main effects of candidate genes and GxE on the neuroendocrine stress response and …
Children's Mental Health, Yvonne A. Asare-Bediako
Children's Mental Health, Yvonne A. Asare-Bediako
Electronic Thesis and Dissertation Repository
The study of children’s mental health has largely been the domain of developmental psychologists and psychiatrists. These studies focus on parental mental health, and examine its direct and indirect effects, through a family’s psychosocial environment. Relatively little attention is given to socio-structural factors. By contrast, the sociology of mental health focuses on such structural factors as poverty and income, examining the extent to which stressors and strains may pattern the effects of these factors on children’s psychopathology. Adding to the divergence in research is the use of maternal reports in the assessment of children’s mental health. These reports often reflect …