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L-Theanine Prevents Long-Term Affective And Cognitive Side Effects Of Adolescent Δ-9-Tetrahydrocannabinol Exposure And Blocks Associated Molecular And Neuronal Abnormalities In The Mesocorticolimbic Circuitry, Marta De Felice, Justine Renard, Roger Hudson, Hanna J. Szkudlarek, Brian J. Pereira, Susanne Schmid, Walter J. Rushlow, Steven R. Laviolette
L-Theanine Prevents Long-Term Affective And Cognitive Side Effects Of Adolescent Δ-9-Tetrahydrocannabinol Exposure And Blocks Associated Molecular And Neuronal Abnormalities In The Mesocorticolimbic Circuitry, Marta De Felice, Justine Renard, Roger Hudson, Hanna J. Szkudlarek, Brian J. Pereira, Susanne Schmid, Walter J. Rushlow, Steven R. Laviolette
Brain and Mind Institute Researchers' Publications
Chronic adolescent exposure to Δ-9-tetrahydrocannabinol (THC) is linked to elevated neuropsychiatric risk and induces neuronal, molecular and behavioral abnormalities resembling neuropsychiatric endophenotypes. Previous evidence has revealed that the mesocorticolimbic circuitry, including the prefrontal cortex (PFC) and mesolimbic dopamine (DA) pathway are particularly susceptible to THC-induced pathologic alterations, including dysregulation of DAergic activity states, loss of PFC GABAergic inhibitory control and affective and cognitive abnormalities. There are currently limited pharmacological intervention strategies capable of preventing THC-induced neuropathological adaptations. L-Theanine is an amino acid analog of L-glutamate and L-glutamine derived from various plant sources, including green tea leaves. L-Theanine has previously been …
Cognitive Organization, Perceptions Of Parenting And Depression Symptoms In Early Adolescence, M. N. Lumley, David J. A. Dozois, K. H. Hennig, A. Marsh
Cognitive Organization, Perceptions Of Parenting And Depression Symptoms In Early Adolescence, M. N. Lumley, David J. A. Dozois, K. H. Hennig, A. Marsh
Psychology Publications
Despite its strong relation to depression and theorized development across childhood and adolescence, cognitive schema organization has not been explored in early adolescence, a sensitive developmental period for first depression onset. Schema organization is theorized to derive from childhood cognitive internalizations of caregiving relationships, such as critical parenting experiences (e.g., Young et al. in Schema therapy: a practitioner’s guide. Guilford Press, New York, 2003). Thus, the current investigation considers the organization of positive and negative schemas with youth’s perceptions of parental warmth and psychological control and self-reported emotional functioning. Participants were 198 boys and girls aged 9–14 years who completed …