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The Kappa Opioid Agonist, Salvinorin A, Attenuates Locomotor Effects Of Morphine But Not Morphine-Induced Conditioned Place Preference, Stacy Dianne Engebretson
The Kappa Opioid Agonist, Salvinorin A, Attenuates Locomotor Effects Of Morphine But Not Morphine-Induced Conditioned Place Preference, Stacy Dianne Engebretson
Masters Theses
Salvinorin A (SA), a selective kappa opioid receptor agonist, is the main psychoactive ingredient in the plant Salvia divinorum. The addiction potential of this naturally occurring hallucinogen is currently under investigation using well-validated preclinical screening procedures, including conditioned place preference (CPP). The primary aim of the current study was to determine the effects of SA on CPP established by morphine in adult rats. A secondary aim was to determine if the vehicle used to dissolve SA, dimethylsulfoxide (DMSO), influenced the outcome of SA place conditioning. Rats were randomly assigned to one of four treatment groups: morphine (10 mg/kg) vs. …