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Dissociable Antidepressant-Like And Abuse-Related Effects Of The Noncompetitive Nmda Receptor Antagonists Ketamine And Mk-801 In Rats., Todd Hillhouse
Dissociable Antidepressant-Like And Abuse-Related Effects Of The Noncompetitive Nmda Receptor Antagonists Ketamine And Mk-801 In Rats., Todd Hillhouse
Theses and Dissertations
The noncompetitive NMDA receptor antagonist ketamine produces rapid and sustained antidepressant effects in patients suffering from major depressive disorder. However, abuse liability is a concern. To further evaluate the relationship between antidepressant-like and abuse-related effects of NMDA receptor antagonists, this study evaluated the effects of ketamine, MK-801, and phencyclidine in male Sprague-Dawley rats responding under two procedures that have been used to assess antidepressant-like effects [differential-reinforcement-of-low-rate (DRL) 72 s schedule of food reinforcement] and abuse-related drug effects [intracranial self-stimulation (ICSS)]. Under DRL 72 s, ketamine produced an antidepressant-like effect by increasing reinforcers, decreasing responses, and producing a rightward shift in …