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The Prevalence Rate And Neurocognitive Morbidity Associated With Obstructive Sleep Apnea In Children With Sickle Cell Disease, Tal Katz
Theses and Dissertations
Sickle-cell disease (SCD) refers to a group of genetic blood disorders resulting from the inheritance of genes for S-type hemoglobin. The disease is life-long and is associated with multiple complications including pain episodes, organ damage, and neurological morbidities such as stroke, and silent cerebral infarcts which often lead to cognitive dysfunction. Obstructive sleep apnea (OSA) is a serious medical condition characterized by intermittent hypoxemia (reduction in blood oxygen levels), hypoxia, and fragmented sleep that can lead patients to suffer from daytime behavioral and cognitive dysfunction and reduced quality of life. Children with SCD are at high risk for developing OSA, …
Integrating Biomedical And Psychosocial Approaches To Study Pain In Pediatric Sickle Cell Disease, Alyssa M. Schlenz
Integrating Biomedical And Psychosocial Approaches To Study Pain In Pediatric Sickle Cell Disease, Alyssa M. Schlenz
Theses and Dissertations
Sickle cell disease (SCD) is a group of inherited blood disorders characterized by recurrent pain. A distinctive obstacle to managing pain in this condition is the substantial heterogeneity of outcomes observed in children, including the rate, intensity, duration, and extent of disability from pain. Previous studies have largely examined this heterogeneity by focusing on either biomedical or psychosocial approaches to this condition rather than pursuing an integrated approach that is consistent with modern conceptualizations of pain. In addition, few studies have examining genetic heterogeneity in pediatric SCD, which remains one of the only strategies for establishing a preventative approach to …