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Personality As A Predictor Of Patterns Of Substance Use, Cynthia Sergi Dec 2021

Personality As A Predictor Of Patterns Of Substance Use, Cynthia Sergi

University of New Orleans Theses and Dissertations

Substance use (SU) affects many people worldwide and is an important public health concern. Personality has been theorized to play a crucial role in the development and maintenance of SU. To test how personality is related to patterns of SU, a latent profile analysis was used to cluster individuals into SU classes with multinomial logistic regression used to test the relationship between personality and patterns of SU. Results suggested that polysubstance use was common, with variations in primary substance of choice among classes. As classes became more inclusive of more substances, they increased in psychopathological personality traits. Higher domains of …


Having A High-Activity Catechol-O-Methyltransferase Allele Is Associated With Elevated Anxiety And Lower Salivary Dehydroepiandrosterone But Also Lower Alpha Amylase In Children With Chromosome 22q11.2 Deletion Syndrome., Jessie Beebe Aug 2021

Having A High-Activity Catechol-O-Methyltransferase Allele Is Associated With Elevated Anxiety And Lower Salivary Dehydroepiandrosterone But Also Lower Alpha Amylase In Children With Chromosome 22q11.2 Deletion Syndrome., Jessie Beebe

University of New Orleans Theses and Dissertations

Chromosome 22q11.2 deletion syndrome (22q11.2DS) results from a hemizygous deletion located on the long arm of chromosome 22. The most common deletion sizes affect between 30 and 90 genes. Individuals with 22q11.2DS may develop serious developmental and psychiatric disorders. The phenotype is highly variable, however, and may be influenced by allelic variation of the retained copies of genes covered by the deletion. I set out to examine the effects of two genes, catechol-O-methyltransferase (COMT) and proline dehydrogenase (PRODH), in relation to anxiety in children and adolescents with 22q11.2DS. Individuals with the major COMT allele (higher activity) have significantly higher anxiety …


Atypical Structural Neuroconnectivity Associated With Emotional Face Processing And Clinical Affect In Children With Chromosome 22q11.2 Deletion Syndrome, David Dodd Stephenson Jr May 2021

Atypical Structural Neuroconnectivity Associated With Emotional Face Processing And Clinical Affect In Children With Chromosome 22q11.2 Deletion Syndrome, David Dodd Stephenson Jr

University of New Orleans Theses and Dissertations

Schizophrenia spectrum disorder (SCZ) is a debilitating psychiatric disorder that affects approximately 1% of the general population. The etiopathology of this disorder is not fully understood with genetic and environmental factors underpinning vulnerability and disease progression. Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) are at ultra-high risk for developing SCZ with 30% developing the disorder in adolescence or young adulthood. To investigate associations with psychosis vulnerability, much work has been performed looking at neurological underpinnings between schizophrenia and 22q11.2DS to assess similarities between both genetic and idiopathic forms of schizophrenia in adults. However, many past studies have assessed this using …


Victim Impact: The Manson Murders And The Rise Of The Victims’ Rights Movement, Merrill W. Steeg May 2021

Victim Impact: The Manson Murders And The Rise Of The Victims’ Rights Movement, Merrill W. Steeg

University of New Orleans Theses and Dissertations

No abstract provided.


The Complexities Of Crankiness And Cortisol: Exploring The Association Between Irritability, Cortisol Reactivity, And Psychopathology, Rachel Kaplan May 2021

The Complexities Of Crankiness And Cortisol: Exploring The Association Between Irritability, Cortisol Reactivity, And Psychopathology, Rachel Kaplan

University of New Orleans Theses and Dissertations

Irritability is an indicator and predictor of psychopathology, as well as a sign of acute and chronic stress. Cortisol reactivity (CR), a physiological index of psychological stress, is bidirectionally associated with and predictive of psychopathology. Research addressing irritability and CR together is limited. Participants were 156 children enrolled in a longitudinal study. At age three, saliva was collected in relation to a stressor task and parents reported on child psychopathology. Psychopathology reports were also completed for ages six, nine, and 12. Results showed CR to have a moderating effect on the association between irritability and psychopathology symptoms when sex was …


The Relation Between Socioeconomic Status And Neuroanatomy Of Language Regions In Children With Autism Spectrum Disorder, Lauren Tra May 2021

The Relation Between Socioeconomic Status And Neuroanatomy Of Language Regions In Children With Autism Spectrum Disorder, Lauren Tra

Senior Honors Theses

Socioeconomic status (SES) is defined as a multifaceted index of a person’s financial resources, education, and relative social status and is dictated by parental education, income, and occupation. SES has been known to impact neurocognitive abilities, such as language acquisition and development through distal systems, which includes variations in household income and education. These systems in turn affect language regions in the brain due to disparities in word exposure, exposure to chronic stress, and disparities in the exposure of varying complexity of words, causing language deficits. Language deficits are a core feature of autism spectrum disorder (ASD), and several studies …