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Galantamine-Induced Tremulous Jaw Movements In Rats: Reversal With Adenosine A2a Antagonists, Chelsea Elizabeth Leser

Honors Scholar Theses

Alzheimer's disease is the most common neurdegenerative disorder, affecting millions of people worldwide. The underlying etiology of Alzheimer's disease, however, is such that treatment is difficult.

Researchers have linked a decrease in the transmission of the neurotransmitter acetylcholine to the cognitive deficits seen in Alzheimer's disease. Recent drug therapies have focused on using drugs that block the action of the enzyme, acetylcholinesterase, that breaks down acetylcholine. However, these drugs, known as acetylcholinesterase inhibitors, have been found to produce side effects that have the same characteristics as Parkinson's disease, the second most common neurodegenerative disorder. In this study, the acetylcholinesterase inhibitor, …