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Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao
Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao
Kristy Nielson
Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ?4 allele could moderate the effect of PA or CA on hippocampal structure or …