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- Arousal (4)
- Exercise (4)
- FMRI (3)
- Physical activity (3)
- Aging (2)
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- Alzheimer's Disease (2)
- Apolipoprotein E (2)
- Cognition (2)
- Cognitive decline (2)
- Magnetic resonance imaging (2)
- Memory (2)
- Memory modulation (2)
- Mild cognitive impairment (2)
- Neuroimaging (2)
- Sex differences (2)
- APOE "4 (1)
- APOE e4 allele (1)
- APOE genotype (1)
- APOE-episolin4 Allele Genetic Risk (1)
- Affect perception (1)
- Age-Related Cognitive Decline (1)
- Alzheimer's disease (1)
- Alzheimer’s disease (1)
- Amygdala (1)
- Apolipoprotein-E (1)
- Applied memory (1)
- Area under the curve (AUC) (1)
- Attention (1)
- Cognitive activity (1)
- Consolidation (1)
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Articles 1 - 19 of 19
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Memory Modulation In The Classroom: Selective Enhancement Of College Examination Performance By Arousal Induced After Lecture, Kristy A. Nielson, Timothy J. Arentsen
Memory Modulation In The Classroom: Selective Enhancement Of College Examination Performance By Arousal Induced After Lecture, Kristy A. Nielson, Timothy J. Arentsen
Kristy Nielson
Laboratory studies examining moderate physiological or emotional arousal induced after learning indicate that it enhances memory consolidation. Yet, no studies have yet examined this effect in an applied context. As such, arousal was induced after a college lecture and its selective effects were examined on later exam performance. Participants were divided into two groups who either watched a neutral video clip (n = 66) or an arousing video clip (n = 70) after lecture in a psychology course. The final examination occurred two weeks after the experimental manipulation. Only performance on the group of final exam items that covered material …
Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Smith, Kristy Nielson, John Woodard, Michael Seidenberg, Matthew Verber, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa Lancaster, Stephen Rao
Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Smith, Kristy Nielson, John Woodard, Michael Seidenberg, Matthew Verber, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa Lancaster, Stephen Rao
Kristy Nielson
The effect of physical activity (PA) on functional brain activation for semantic memory in amnestic mild cognitive impairment (aMCI) was examined using event-related functional magnetic resonance imaging during fame discrimination. Significantly greater semantic memory activation occurred in the left caudate of High- versus Low-PA patients, (P=0.03), suggesting PA may enhance memory-related caudate activation in aMCI.
A Task To Manipulate Attentional Load, Set-Shifting, And Inhibitory Control: Convergent Validity And Test–Retest Reliability Of The Parametric Go/No-Go Test, Scott Aaron Langenecker, Jon-Kar Zubieta, Elizabeth Young, Kristy Nielson
A Task To Manipulate Attentional Load, Set-Shifting, And Inhibitory Control: Convergent Validity And Test–Retest Reliability Of The Parametric Go/No-Go Test, Scott Aaron Langenecker, Jon-Kar Zubieta, Elizabeth Young, Kristy Nielson
Kristy Nielson
Traditional neuropsychological measures of executive functioning are difficult to employ in functional imaging and clinical trial contexts and have tremendous practice effects. They also have poor sensitivity and specificity, while test–retest reliability is often not assessed in computer-based tests. The present study evaluates some psychometric properties of a new Parametric Go/No-Go (PGNG) Task. The PGNG consists of three levels of difficulty assessing attention, set-shifting, and processing speed, with the two more difficult levels assessing inhibitory control. A total of 63 healthy control participants were recruited at two sites to evaluate the psychometric properties of the PGNG. The PGNG was found …
Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao
Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao
Kristy Nielson
Leisure-time physical activity (PA) and exercise training are known to help maintain cognitive function in healthy older adults. However, relatively little is known about the effects of PA on cognitive function or brain function in those at increased risk for Alzheimer’s disease through the presence of the apolipoproteinE epsilon4 (APOE-ε4) allele, diagnosis of mild cognitive impairment (MCI), or the presence of metabolic disease. Here, we examine the question of whether PA and exercise interventions may differentially impact cognitive trajectory, clinical outcomes, and brain structure and function among individuals at the greatest risk for AD. The literature suggests that the protective …
Functional Magnetic Resonance Imaging Of Semantic Memory As A Presymptomatic Biomarker Of Alzheimer’S Disease Risk, Michael Sugarman, John L. Woodard, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Stephen M. Rao
Functional Magnetic Resonance Imaging Of Semantic Memory As A Presymptomatic Biomarker Of Alzheimer’S Disease Risk, Michael Sugarman, John L. Woodard, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Stephen M. Rao
Kristy Nielson
Extensive research efforts have been directed toward strategies for predicting risk of developing Alzheimer's disease (AD) prior to the appearance of observable symptoms. Existing approaches for early detection of AD vary in terms of their efficacy, invasiveness, and ease of implementation. Several non-invasive magnetic resonance imaging strategies have been developed for predicting decline in cognitively healthy older adults. This review will survey a number of studies, beginning with the development of a famous name discrimination task used to identify neural regions that participate in semantic memory retrieval and to test predictions of several key theories of the role of the …
Memory For Emotionally Provocative Words In Alexithymia: A Role For Stimulus Relevance, Mitchell Meltzer, Kristy A. Nielson
Memory For Emotionally Provocative Words In Alexithymia: A Role For Stimulus Relevance, Mitchell Meltzer, Kristy A. Nielson
Kristy Nielson
Alexithymia is associated with emotion processing deficits, particularly for negative emotional information. However, also common are a high prevalence of somatic symptoms and the perception of somatic sensations as distressing. Although little research has yet been conducted on memory in alexithymia, we hypothesized a paradoxical effect of alexithymia on memory. Specifically, recall of negative emotional words was expected to be reduced in alexithymia, while memory for illness words was expected to be enhanced in alexithymia. Eighty-five high or low alexithymia participants viewed and rated arousing illness-related ("pain"), emotionally positive ("thrill"), negative ("hatred"), and neutral words ("horse"). Recall was assessed 45 …
Gender Specific Disruptions In Emotion Processing In Younger Adults With Depression, Sara L. Wright, Scott Aaron Langenecker, Patricia J. Deldin, Lisa J. Rapport, Kristy A. Nielson, Allison M. Kade, Lawrence S. Own, Huda Akil, Elizabeth A. Young, Jon-Kar Zubieta
Gender Specific Disruptions In Emotion Processing In Younger Adults With Depression, Sara L. Wright, Scott Aaron Langenecker, Patricia J. Deldin, Lisa J. Rapport, Kristy A. Nielson, Allison M. Kade, Lawrence S. Own, Huda Akil, Elizabeth A. Young, Jon-Kar Zubieta
Kristy Nielson
Background: One of the principal theories regarding the biological basis of major depressive disorder (MDD) implicates a dysregulation of emotion-processing circuitry. Gender differences in how emotions are processed and relative experience with emotion processing might help to explain some of the disparities in the prevalence of MDD between women and men. This study sought to explore how gender and depression status relate to emotion processing. Methods: This study employed a 2 (MDD status) × 2 (gender) factorial design to explore differences in classifications of posed facial emotional expressions (N=151). Results: For errors, there was an …
Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao
Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao
Kristy Nielson
Previous studies suggest that task-activated functional magnetic resonance imaging (fMRI) can predict future cognitive decline among healthy older adults. The present fMRI study examined the relative sensitivity of semantic memory (SM) versus episodic memory (EM) activation tasks for predicting cognitive decline. Seventy-eight cognitively intact elders underwent neuropsychological testing at entry and after an 18-month interval, with participants classified as cognitively “Stable” or “Declining” based on ≥1.0 SD decline in performance. Baseline fMRI scanning involved SM (famous name discrimination) and EM (name recognition) tasks. SM and EM fMRI activation, along with Apolipoprotein E (APOE) ε4 status, served as predictors of cognitive …
Recognition Of Famous Names Predicts Cognitive Decline In Healthy Elders, Michael Seidenberg, Christina D. Kay, John L. Woodard, Kristy A. Nielson, J. Carson Smith, Cassandra Kandah, Leslie Guidotti, Julia Novitski, Melissa A. Lancaster, Monica Matthews, Nathan Hantke, Alissa Butts, Stephen M. Rao
Recognition Of Famous Names Predicts Cognitive Decline In Healthy Elders, Michael Seidenberg, Christina D. Kay, John L. Woodard, Kristy A. Nielson, J. Carson Smith, Cassandra Kandah, Leslie Guidotti, Julia Novitski, Melissa A. Lancaster, Monica Matthews, Nathan Hantke, Alissa Butts, Stephen M. Rao
Kristy Nielson
Objective: The ability to recognize familiar people is impaired in both Mild Cognitive Impairment (MCI) and Alzheimer’s Dementia (AD). In addition, both groups often demonstrate a time-limited temporal gradient (TG) in which well known people from decades earlier are better recalled than those learned recently. In this study, we examined the TG in cognitively intact elders for remote famous names (1950–1965) compared to more recent famous names (1995–2005). We hypothesized that the TG pattern on a famous name recognition task (FNRT) would predict future cognitive decline, and also show a significant correlation with hippocampal volume. Method: Seventy-eight healthy elders (ages …
Individual Differences Associated With The Repeated Endorsement Of Post-Event Misinformation, Timothy Arentsen, Benjamin Bock, Kristy Nielson
Individual Differences Associated With The Repeated Endorsement Of Post-Event Misinformation, Timothy Arentsen, Benjamin Bock, Kristy Nielson
Kristy Nielson
No abstract provided.
Semantic Memory Activation In Amnestic Mild Cognitive Impairment, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, Piero Antuono, Leslie Guidotti, Sally Durgerian, Qi Zhang, Melissa A. Lancaster, Nathan Hantke, Alissa Butts, Stephen M. Rao
Semantic Memory Activation In Amnestic Mild Cognitive Impairment, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, Piero Antuono, Leslie Guidotti, Sally Durgerian, Qi Zhang, Melissa A. Lancaster, Nathan Hantke, Alissa Butts, Stephen M. Rao
Kristy Nielson
Cognitively intact older individuals at risk for developing Alzheimer’s disease frequently show increased functional magnetic resonance imaging (fMRI) brain activation presumably associated with compensatory recruitment, whereas mild cognitive impairment (MCI) patients tend not to show increased activation presumably due to reduced neural reserve. Previous studies, however, have typically used episodic memory activation tasks, placing MCI participants at a performance disadvantage relative to healthy elders. In this event-related fMRI study, we employed a low effort, high accuracy semantic memory task to determine if increased activation of memory circuits is preserved in amnestic MCI when task performance is controlled. Fifty-seven participants, aged …
Reduction Of The Misinformation Effect By Arousal Induced After Learning, Shaun English, Kristy Nielson
Reduction Of The Misinformation Effect By Arousal Induced After Learning, Shaun English, Kristy Nielson
Kristy Nielson
Misinformation introduced after events have already occurred causes errors in later retrieval. Based on literature showing that arousal induced after learning enhances delayed retrieval, we investigated whether post-learning arousal can reduce the misinformation effect. 251 participants viewed four short film clips, each followed by a retention test, which for some participants included misinformation. Afterward, participants viewed another film clip that was either arousing or neutral. One week later, the arousal group recognized significantly more veridical details and endorsed significantly fewer misinformation items than the neutral group. The findings suggest that arousal induced after learning reduced source confusion, allowing participants to …
Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Kristy Nielson
Evidence suggests that physical activity (PA) is associated with the maintenance of cognitive function across the lifespan. In contrast, the apolipoproteinE-ε4 (APOE-ε4) allele, a genetic risk factor for Alzheimer's disease (AD), is associated with impaired cognitive function. The objective of this study was to examine the interactive effects of PA and APOE-ε4 on brain activation during memory processing in older (ages 65–85) cognitively intact adults. A cross-sectional design was used with four groups (n = 17 each): (1) Low Risk/Low PA; (2) Low Risk/High PA; (3) High Risk/Low PA; and (4) High Risk/High PA. PA level was based on …
Stressor-Induced Increase In Muscle Fatigability Of Young Men And Women Is Predicted By Strength But Not Voluntary Activation, Manda Keller-Ross, Hugo Pereia, Jaclyn Pruse, Tejin Yoon, Bonnie Schlinder-Delap, Kristy Nielson, Sandra Hunter
Stressor-Induced Increase In Muscle Fatigability Of Young Men And Women Is Predicted By Strength But Not Voluntary Activation, Manda Keller-Ross, Hugo Pereia, Jaclyn Pruse, Tejin Yoon, Bonnie Schlinder-Delap, Kristy Nielson, Sandra Hunter
Kristy Nielson
This study investigated mechanisms for the stressor-induced changes in muscle fatigability in men and women. Participants performed an isometric-fatiguing contraction at 20% maximal voluntary contraction (MVC) until failure with the elbow flexor muscles. Study one (n = 55; 29 women) involved two experimental sessions: 1) a high-stressor session that required a difficult mental-math task before and during a fatiguing contraction and 2) a control session with no mental math. For some participants (n = 28; 14 women), cortical stimulation was used to examine mechanisms that contributed to muscle fatigability during the high-stressor and control sessions. Study two (n = 23; …
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Kristy Nielson
Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …
Risk Factors For Alzheimer’S Disease And Longitudinal Memory Performance, M. K. Foster, M. Seidenberg, J. Woodard, Kristy A. Nielson, J. Smith, M. Lancaster, M. Matthews, N. Hantke, A. Butts, S. Rao
Risk Factors For Alzheimer’S Disease And Longitudinal Memory Performance, M. K. Foster, M. Seidenberg, J. Woodard, Kristy A. Nielson, J. Smith, M. Lancaster, M. Matthews, N. Hantke, A. Butts, S. Rao
Kristy Nielson
No abstract provided.
Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao
Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao
Kristy Nielson
Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ?4 allele could moderate the effect of PA or CA on hippocampal structure or …
Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Kristy Nielson
Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders. This prospective study evaluated individual and combined contributions of demographic information, genetic risk, hippocampal volume, and fMRI activation for predicting cognitive decline after an 18-month retest interval. Standardized neuropsychological testing, an fMRI semantic memory task (famous name discrimination), and structural MRI (sMRI) were performed on 78 healthy elders (73% female; mean age = 73 years, range = 65 to 88 years). Positive family history of dementia and presence of one or both apolipoprotein …
Enhanced Post-Learning Memory Consolidation Is Influenced By Arousal Predisposition And Emotion Regulation But Not By Stimulus Valence Or Arousal, Kristy Nielson, William Lorber
Enhanced Post-Learning Memory Consolidation Is Influenced By Arousal Predisposition And Emotion Regulation But Not By Stimulus Valence Or Arousal, Kristy Nielson, William Lorber
Kristy Nielson
Emotionally arousing stimuli are more memorable than neutral ones and arousal induced after learning enhances later retrieval. However, there is as yet little study of how stimulus qualities might interact with induced arousal and how individual differences might influence the modulation of memory. Thus, the present study examined the effect of arousal induced after learning on memory for words that varied in both arousal and valence quality, as well as the influence of three individual differences factors that are known to influence arousal response: emotional suppression, emotional reappraisal, and arousal predisposition. Seventy-six adults (57 female) viewed and rated 60 words …