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The Multimodal Antidepressant Vortioxetine May Facilitate Pyramidal Cell Firing By Inhibition Of 5-Ht3 Receptor Expressing Interneurons: An In Vitro Study In Rat Hippocampus Slices, Elena Dale, Morten Grunnet, Alan Pehrson, Kristen Frederiksen, Peter H. Larsen, Jacob Nielsen, Tine B. Stensbøl, Bjarke Ebert, Haolan Yin, Dunguo Lu, Huiquing Liu, Thomas N. Jensen, Charles R. Yang, Connie Sanchez
The Multimodal Antidepressant Vortioxetine May Facilitate Pyramidal Cell Firing By Inhibition Of 5-Ht3 Receptor Expressing Interneurons: An In Vitro Study In Rat Hippocampus Slices, Elena Dale, Morten Grunnet, Alan Pehrson, Kristen Frederiksen, Peter H. Larsen, Jacob Nielsen, Tine B. Stensbøl, Bjarke Ebert, Haolan Yin, Dunguo Lu, Huiquing Liu, Thomas N. Jensen, Charles R. Yang, Connie Sanchez
Department of Psychology Faculty Scholarship and Creative Works
The multimodal antidepressant vortioxetine is thought to mediate its pharmacological effects via 5-HT 1A receptor agonism, 5-HT 1B receptor partial agonism, 5-HT 1D , 5-HT 3 , 5-HT 7 receptor antagonism and 5-HT transporter inhibition. Here we studied vortioxetine's functional effects across species (canine, mouse, rat, guinea pig and human) in cellular assays with heterologous expression of 5-HT 3A receptors (in Xenopus oocytes and HEK-293 cells) and in mouse neuroblastoma N1E-115 cells with endogenous expression of 5-HT 3A receptors. Furthermore, we studied the effects of vortioxetine on activity of CA1 Stratum Radiatum interneurons in rat hippocampus slices using current- and …