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Impact Of Childhood Trauma On Skin Conductance Response To Fear, Safety, And Reward, Tristan Alana Gregg

Master's Theses (2009 -)

Trauma is associated with neurological and physiological differences that can persist years after trauma exposure. Physiologically, trauma has been associated with altered responses to cues in the environment, most commonly threatening stimuli. For instance, in participants who experience trauma during adulthood, such individuals exhibit heightened physiological arousal. Conversely, other studies have found that childhood trauma may be associated with blunted physiological arousal. Most of this research has involved threatening cues, but previous research suggests that trauma is also associated with aberrant physiological arousal responses to positive or rewarding cues. Skin conductance responses (SCRs) are a commonly utilized measure of physiological …

Neighborhood Socioeconomic Disadvantage And The Neurobiology Of Uncertainty In Traumatically Injured Adults, Carissa W. Tomas, E. Kate Webb, Kenneth P. Bennett, Ashley A. Huggins, Jacklynn M. Fitzgerald, Tara A. Miskovich, Jessica L. Krukowski, Terri A. Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

Individuals residing in more socioeconomically disadvantaged neighborhoods experience greater uncertainty through insecurity of basic needs such as food, employment, and housing, compared with more advantaged neighborhoods. Although the neurobiology of uncertainty has been less frequently examined in relation to neighborhood disadvantage, there is evidence that neighborhood disadvantage is associated with widespread neural alterations.

Methods

Recently traumatically injured participants (n = 90) completed a picture anticipation task in the magnetic resonance imaging scanner, in which they viewed images presented in a temporally predictable or unpredictable manner. We investigated how neighborhood disadvantage (via area deprivation index [ADI]) was related to …

Psychophysiological Predictors Of Change In Emotion Dysregulation 6 Months After Traumatic Injury, Jacklynn M. Fitzgerald, Sydney Clare Timmer-Murillo, Claire Sheeran, Hailey Begg, Morgan Christoph, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Emotional dysregulation that occurs after trauma conveys risk for multiple disorders, including posttraumatic stress disorder, depression, and anxiety. Psychophysiological data (e.g., skin conductance level [SCL]) may be a useful biomarker for quantifying emotion dysregulation given that autonomic nervous system (ANS)-mediated arousal may underlie this feature. In this longitudinal study, we tested whether SCL collected following a single-incident traumatic injury could predict changes in emotion dysregulation over 6 months. Sixty-six adults were recruited from the emergency department; SCL was quantified during an active trauma narrative, in which participants re-told their traumatic event to a research staff member, as well as a …

A Cluster Analytic Approach To Examining The Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria In Adult Traumatic Injury Survivors, Devi Jayan, Terri A Deroon-Cassini, Garrett Sauber, Cecilia J. Hillard, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Identification of specific risk factors for posttraumatic stress disorder (PTSD) versus depression after trauma has been challenging, in part due to the high comorbidity of these disorders. As exposure to trauma triggers activation of the hypothalamic-pituitary-adrenal (HPA)-axis, examining atypical stress responses via HPA-axis hormones, namely cortisol, may help in the delineation of these disorders. Indeed, extant research demonstrates that, following stress, individuals with chronic PTSD exhibit hypocortisolism (e.g., lower cortisol response than controls), while those with chronic depression exhibit hypercortisolism (e.g., higher response than controls). Less is known about the role of cortisol and these seemingly disparate profiles immediately following …

Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria, Devi Jayan

Dissertations (1934 -)

Exposure to a traumatic event is a significant predictor for the development of posttraumatic stress disorder (PTSD) and depression. Identification of specific risk factors for PTSD and depression after trauma exposure has been challenging due to comorbid and heterogeneous presentations of these conditions. Pre-existing research demonstrates reduced cortisol response (hypocortisolism) in chronic PTSD and an exaggerated cortisol response (hypercortisolism) in depression. The current longitudinal study examined cortisol response following a traumatic injury as a potential biomarker for deciphering specific risk for PTSD, depression, and PTSD depression comorbidity. Saliva samples for cortisol assay (post-injury cortisol) were collected from 172 trauma survivors …

Acute White Matter Integrity Post-Trauma And Prospective Posttraumatic Stress Disorder Symptoms, Carissa N. Weis, Ashley A. Huggins, Tara A. Miskovich, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Jessica L. Krukowski, E. Kate Webb, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background: Little is known about what distinguishes those who are resilient after trauma from those at risk for developing posttraumatic stress disorder (PTSD). Previous work indicates white matter integrity may be a useful biomarker in predicting PTSD. Research has shown changes in the integrity of three white matter tracts—the cingulum bundle, corpus callosum (CC), and uncinate fasciculus (UNC)—in the aftermath of trauma relate to PTSD symptoms. However, few have examined the predictive utility of white matter integrity in the acute aftermath of trauma to predict prospective PTSD symptom severity in a mixed traumatic injury sample.

Method: Thus, the current study …

Circulating Endocannabinoids And Prospective Risk For Depression In Trauma-Injury Survivors, Jacklynn M. Fitzgerald, Samantha Chesney, Tara Sander Lee, Karen J. Brasel, Christine L. Larson, Cecilia J. Hillard, Terri A Deroon-Cassini

Psychology Faculty Research and Publications

Biological mechanisms associated with response to trauma may impact risk for depression. One such mechanism is endocannabinoid signaling (eCB), a neuromodulatory system comprised of the CB1 subtype of cannabinoid receptors (CB1R), encoded by the CNR1 gene, and two primary endogenous ligands: 2-arachidonoylglycerol (2-AG) and N-arachidonylethanolamine (AEA), hydrolyzed by monoacylglycerol lipase (gene name MGLL) and fatty acid amide hydrolase (gene name FAAH). Preclinical data suggest that eCB/CB1R signaling acts as a stress buffer and its loss or suppression increases depression-like behaviors. We examined circulating concentrations of the eCBs (2-AG and AEA) days and six months after a traumatic injury …

Trauma Therapy For Very Young Children Living In Poverty: A Randomized Controlled Trial, Joanna Ruth Love

Dissertations (1934 -)

This study used a randomized control design with immediate treatment and wait list control conditions to evaluate the efficacy of the New Hope program, a home-based, parent-and-child therapy program that has been developed for very young children living in poverty who experienced one or more potentially traumatizing events. Within a three-phase model of treatment, the New Hope program is designed to establish safety, build the caregiver child relationship, create a nurturing environment, teach coping skills, address trauma-related thoughts and feelings, and develop prosocial skills. Training in this program included discussions regarding the cultural implications of providing therapy services in the …

Profiles Of Emotion Regulation: Understanding Regulatory Patterns And The Implications For Posttraumatic Stress, Samantha Chesney, Nakia Gordon

Psychology Faculty Research and Publications

Trauma survivors often experience posttraumatic stress (PTS) and report concurrent difficulties with emotion regulation (ER). Although individuals typically use multiple regulatory strategies to manage emotion, no studies yet examine the influence of a constellation of strategies on PTS in a community sample. We assessed six ER strategies and investigated whether specific profiles of ER (i.e. the typical pattern of regulation, determined by how often each strategy is used) were related to PTS. A hierarchical cluster analysis indicated that four distinct profiles were present: Adaptive Regulation, Active Regulation, Detached Regulation, and Maladaptive Regulation. Further analyses revealed that an individual's profile …

A Naturalistic Study Of Narrative: Exploring The Choice And Impact Of Adversity Versus Other Narrative Topics, Sherry L. Hamby, Elizabeth Taylor, John H. Grych, Victoria Banyard

Psychology Faculty Research and Publications

Objective: Many narrative interventions require participants to write about trauma and adverse experiences, but some research suggests that open-ended topic prompts can also be effective. In this study, we investigated the topics participants chose to write about in a values-narrative program that offered wide discretion in topic and theme, and explored how that was associated with perceptions of investment and impact. Method: Participants were 717 individuals (68% women) from the rural South, United States who had participated in a values-narrative program. Results: Almost half of the narratives (44%) focused on an adverse experience as part of the development of their …

Development Of The Early Childhood Traumatic Stress Screen, Sara Elisabeth Harris

Dissertations (1934 -)

The study aimed to develop a brief screening instrument to assess symptoms associated with potentially traumatic experiences (PTE) in very young children (under 6). Potential items for the Early Childhood Traumatic Stress Screen (ECTSS) were sampled from each of the major content areas implicated in trauma. The items underwent a principle component analysis, which produced a 34-item screening measure with four reliable factors and one sub-scale assessing response style. All subscales and the overall trauma composite score significantly correlated with pre-established measures of traumatic stress in very young children, and a receiver operating characteristics curve analysis identified a cut-score with …

Long Term Effects Of Chronic Variable Stress Administered During Different Developmental Stages In Mice, Henry Boeh

Dissertations (1934 -)

A number of studies have suggested that the occurrence of past trauma can increase an individual's chance of developing PTSD from a new traumatic experience later in life. Trauma that occurs during childhood appears to have a particularly strong effect on this risk increase. Furthermore, conditioned fear responses have been shown to incubate over extended periods of time in animal models. To further investigate the role these phenomena play in the development of PTSD, this study exposed juvenile and adult mice to 7 days of chronic variable stress (CVS). One month later, a Pavlovian delay fear conditioning procedure was used …