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Minority Stress And Leukocyte Gene Expression In Sexual Minority Men Living With Treated Hiv Infection, Annesa Flentje, Kord M. Kober, Adam W. Carrico, Torsten B. Neilands, Elana Flowers, Nicholas C. Heck, Bradley E. Aouizerat
Minority Stress And Leukocyte Gene Expression In Sexual Minority Men Living With Treated Hiv Infection, Annesa Flentje, Kord M. Kober, Adam W. Carrico, Torsten B. Neilands, Elana Flowers, Nicholas C. Heck, Bradley E. Aouizerat
Psychology Faculty Research and Publications
Sexual minority (i.e., non-heterosexual) individuals experience poorer mental and physical health, accounted for in part by the additional burden of sexual minority stress occurring from being situated in a culture favoring heteronormativity. Informed by previous research, the purpose of this study was to identify the relationship between sexual minority stress and leukocyte gene expression related to inflammation, cancer, immune function, and cardiovascular function. Sexual minority men living with HIV who were on anti-retroviral medication, had viral load < 200 copies/mL, and had biologically confirmed, recent methamphetamine use completed minority stress measures and submitted blood samples for RNA sequencing on leukocytes. Differential gene expression and pathway analyses were conducted comparing those with clinically elevated minority stress (n = 18) and those who did not meet the clinical cutoff (n = 20), covarying reactive urine toxicology results for very …
Estimating Hiv Medication Adherence And Persistence: Two Instruments For Clinical And Research Use, David A. Wohl, A. T. Panter, Christine Kirby, Brooke E. Magnus, Michael G. Hudgens, Andrew G. Allmon, Katie R. Mollan
Estimating Hiv Medication Adherence And Persistence: Two Instruments For Clinical And Research Use, David A. Wohl, A. T. Panter, Christine Kirby, Brooke E. Magnus, Michael G. Hudgens, Andrew G. Allmon, Katie R. Mollan
Psychology Faculty Research and Publications
Antiretroviral therapy (ART) requires lifelong daily oral therapy. While patient characteristics associated with suboptimal ART adherence and persistence have been described in cohorts of HIV-infected persons, these factors are poor predictors of individual medication taking behaviors. We aimed to create and test instruments for the estimation of future ART adherence and persistence for clinical and research applications. Following formative work, a battery of 148 items broadly related to HIV infection and treatment was developed and administered to 181 HIV-infected patients. ART adherence and persistence were assessed using electronic monitoring for 3 months. Perceived confidence in medication taking and self-reported barriers …