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Five-Year Longitudinal Brain Volume Change In Healthy Elders At Genetic Risk For Alzheimer's Disease, Katherine Reiter, Kristy A. Nielson, Sally Durgerian, John L. Woodard, J. Carson Smith, Michael Seidenberg, Dana A. Kelly, Stephen M. Rao
Five-Year Longitudinal Brain Volume Change In Healthy Elders At Genetic Risk For Alzheimer's Disease, Katherine Reiter, Kristy A. Nielson, Sally Durgerian, John L. Woodard, J. Carson Smith, Michael Seidenberg, Dana A. Kelly, Stephen M. Rao
Psychology Faculty Research and Publications
No abstract provided.
Diffusion Tensor Imaging Predictors Of Episodic Memory Decline In Healthy Elders At Genetic Risk For Alzheimer’S Disease, Melissa A. Lancaster, Michael Seidenberg, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Sally Durgerian, Stephen M. Rao
Diffusion Tensor Imaging Predictors Of Episodic Memory Decline In Healthy Elders At Genetic Risk For Alzheimer’S Disease, Melissa A. Lancaster, Michael Seidenberg, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Sally Durgerian, Stephen M. Rao
Psychology Faculty Research and Publications
Objectives: White matter (WM) integrity within the mesial temporal lobe (MTL) is important for episodic memory (EM) functioning. The current study investigated the ability of diffusion tensor imaging (DTI) in MTL WM tracts to predict 3-year changes in EM performance in healthy elders at disproportionately higher genetic risk for Alzheimer’s disease (AD). Methods: Fifty-one cognitively intact elders (52% with family history (FH) of dementia and 33% possessing an Apolipoprotein E ε4 allelle) were administered the Rey Auditory Verbal Learning Test (RAVLT) at study entry and at 3-year follow-up. DTI scanning, conducted at study entry, examined fractional anisotropy and mean, radial …
Interactive Effects Of Physical Activity And Apoe-Ε4 On White Matter Tract Diffusivity In Healthy Elders, J. Carson Smith, Melissa A. Lancaster, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Ken Sakaie, Stephen M. Rao
Interactive Effects Of Physical Activity And Apoe-Ε4 On White Matter Tract Diffusivity In Healthy Elders, J. Carson Smith, Melissa A. Lancaster, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Ken Sakaie, Stephen M. Rao
Psychology Faculty Research and Publications
Older adult apolipoprotein-E epsilon 4 (APOE-ε4) allele carriers vary considerably in the expression of clinical symptoms of Alzheimer's disease (AD), suggesting that lifestyle or other factors may offer protection from AD-related neurodegeneration. We recently reported that physically active APOE-ε4 allele carriers exhibit a stable cognitive trajectory and protection from hippocampal atrophy over 18 months compared to sedentary ε4 allele carriers. The aim of this study was to examine the interactions between genetic risk for AD and physical activity (PA) on white matter (WM) tract integrity, using diffusion tensor imaging (DTI) MRI, in this cohort of healthy older adults (ages …
Exercise Training And Functional Connectivity Changes In Mild Cognitive Impairment And Healthy Elders, Theresa J. Chirles, Katherine Reiter, Lauren R. Weiss, Alfonso J. Alfini, Kristy A. Nielson, J. Smith Carson
Exercise Training And Functional Connectivity Changes In Mild Cognitive Impairment And Healthy Elders, Theresa J. Chirles, Katherine Reiter, Lauren R. Weiss, Alfonso J. Alfini, Kristy A. Nielson, J. Smith Carson
Psychology Faculty Research and Publications
Background: Effective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer’s disease (AD). The posterior cingulate cortex (PCC)/precuneus is a hub of the default mode network (DMN) and is preferentially vulnerable to disruption of functional connectivity in MCI and AD. Objective: We investigated whether 12 weeks of aerobic exercise could enhance functional connectivity of the PCC/precuneus in MCI and healthy elders. Methods: Sixteen MCI and 16 healthy elders (age range = 60–88) engaged in a supervised 12-week walking exercise intervention. Functional MRI was acquired at rest; the PCC/precuneus was used as a …
Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith
Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith
Psychology Faculty Research and Publications
Cortical atrophy is a biomarker of Alzheimer’s disease (AD) that correlates with clinical symptoms. This study examined changes in cortical thickness from before to after an exercise intervention in mild cognitive impairment (MCI) and healthy elders. Thirty physically inactive older adults (14 MCI, 16 healthy controls) underwent MRI before and after participating in a 12-week moderate intensity walking intervention. Participants were between the ages of 61 and 88. Change in cardiorespiratory fitness was assessed using residualized scores of the peak rate of oxygen consumption (V̇O2peak) from pre- to post-intervention. Structural magnetic resonance images were processed using FreeSurfer v5.1.0. …
Genetic Risk For Alzheimer's Disease Alters The Five-Year Trajectory Of Semantic Memory Activation In Cognitively Intact Elders, Stephen M. Rao, Aaron Bonner-Jackson, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, John L. Woodard, Sally Durgerian
Genetic Risk For Alzheimer's Disease Alters The Five-Year Trajectory Of Semantic Memory Activation In Cognitively Intact Elders, Stephen M. Rao, Aaron Bonner-Jackson, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, John L. Woodard, Sally Durgerian
Psychology Faculty Research and Publications
Healthy aging is associated with cognitive declines typically accompanied by increased task-related brain activity in comparison to younger counterparts. The Scaffolding Theory of Aging and Cognition (STAC) (Park and Reuter-Lorenz, 2009; Reuter-Lorenz and Park, 2014) posits that compensatory brain processes are responsible for maintaining normal cognitive performance in older adults, despite accumulation of aging-related neural damage. Cross-sectional studies indicate that cognitively intact elders at genetic risk for Alzheimer's disease (AD) demonstrate patterns of increased brain activity compared to low risk elders, suggesting that compensation represents an early response to AD-associated pathology. Whether this compensatory response persists or declines with the …
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Psychology Faculty Research and Publications
Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …