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Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith
Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith
Psychology Faculty Research and Publications
Cortical atrophy is a biomarker of Alzheimer’s disease (AD) that correlates with clinical symptoms. This study examined changes in cortical thickness from before to after an exercise intervention in mild cognitive impairment (MCI) and healthy elders. Thirty physically inactive older adults (14 MCI, 16 healthy controls) underwent MRI before and after participating in a 12-week moderate intensity walking intervention. Participants were between the ages of 61 and 88. Change in cardiorespiratory fitness was assessed using residualized scores of the peak rate of oxygen consumption (V̇O2peak) from pre- to post-intervention. Structural magnetic resonance images were processed using FreeSurfer v5.1.0. …