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The Role Of Dopamine In Reinforcement: Changes In Reinforcement Sensitivity Induced By D1-Type, D2-Type, And Nonselective Dopamine Receptor Agonists, Natalie Bratcher, Valeri Farmer-Dougan, James Dougan, Byron Heidenreich, Paul Garris

Scholarship

Dose-dependent changes in sensitivity to reinforcement were found when rats were treated with low, moderate, and high doses of the partial dopamine D1-type receptor agonist SKF38393 and with the nonselective dopamine agonist apomorphine, but did not change when rats were treated with similar doses of the selective dopamine D2-type receptor agonist quinpirole. Estimates of bias did not differ significantly across exposure to SKF38393 or quinpirole, but did change significantly at the high dose of apomorphine. Estimates of goodness of fit (r2) did not change significantly during quinpirole exposure. Poor goodness of fit was obtained for the high doses of SKF38393 …