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Ibotenic Acid-Induced Lesions Of The Medial Zona Incerata Decrease Lordosis Behavior In The Female Rat, Melissa Peterson '90
Ibotenic Acid-Induced Lesions Of The Medial Zona Incerata Decrease Lordosis Behavior In The Female Rat, Melissa Peterson '90
Honors Projects
In order to examine the role of the medial zona incerta in female sexual behavior, ovariectomized estrogen and progesterone treated female rats were tested for sexual receptivity following bilateral injections of the selective neurotoxin, ibotenic acid (3 ug/0.3 ul dissolved in phosphate-buffered saline) directly into the medial zona incerta. These injections produced a significant attenuation of lordosis behavior in highly receptive females when compared to saline injected controls (shams). This decrease in sexual receptivity was also reflected in a significant increase of rejections of male mount attempts. Additionally, the frequency of hopping, darting and ear wiggling was significantly decreased in …
Intracerebral Injections Of Morphiceptin Into The Medial Preoptic Area Produce A Delay In The Initiation Of Male Rat Sexual Behavior, Leslie Matuszewich '90
Intracerebral Injections Of Morphiceptin Into The Medial Preoptic Area Produce A Delay In The Initiation Of Male Rat Sexual Behavior, Leslie Matuszewich '90
Honors Projects
Behavioral experiments examined the role of morphiceptin in male rat copulatory behavior. Male copulatory behavior was recorded subsequent to bilateral injections of either 10, 500, or 1000 ng of morphiceptin into the medial preoptic area (MPOA) in sexually vigorous male rats. In the first experiment, all three doses of morphiceptin injected bilaterally into the MPOA produced a dramatic delay in the initiation of copulation. Both mount and intromission latencies significantly increased following injections of all three doses of morphiceptin when compared to saline injected controls. No other parameter was affected. In experiment 2, the inhibitory effects of morphiceptin on male …