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Resurgence Of Cocaine-Seeking In Rats Following Long Access And Punishment, Rusty W. Nall
Resurgence Of Cocaine-Seeking In Rats Following Long Access And Punishment, Rusty W. Nall
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Strategies that provide access to alternative non-drug rewards are among the most effective at reducing substance use in individuals with substance use disorders, but relapse often occurs when alternative rewards are removed. Relapse induced by the loss of alternative rewards is called resurgence, and represents a challenge to otherwise effective strategies for reducing drug use. An animal model has been useful for studying resurgence, but the extant model has two limitations. First, humans usually refer to the negative consequences of drug use as the reason they stop taking drugs, but the extant model uses drug unavailability to reduce drug seeking. …
Examination Of Sex Differences And The Role Of Ovarian Hormones In Modulating Nicotine Withdrawal In Rats, Rodolfo Jesus Flores Garcia
Examination Of Sex Differences And The Role Of Ovarian Hormones In Modulating Nicotine Withdrawal In Rats, Rodolfo Jesus Flores Garcia
Open Access Theses & Dissertations
Introduction: Aim 1 characterized sex differences and the role of ovarian hormones in physical signs and negative affective states produced by nicotine withdrawal in female, ovariectomized female (OVX), and male rats. We also compared nicotine withdrawal and corticosterone levels with estradiol (E2) and progesterone across the 4-day estrous cycle. Aim 2 validated the role of ovarian hormones in withdrawal in OVX females that received vehicle, E2, or E2+progesterone. Methods: Female rats received a sham surgery or an ovariectomy procedure. Fifteen days later, all rats were implanted with a pump that delivered nicotine for 14 days. On the test day, separate …
No Evidence That Portion Size Influences Food Consumption In Male Sprague Dawley Rats, Fabien Naniex, Sophie C. Pinder, Megan Y. Summers, Renee M. Rouleau, Eric Robinson, Kevin P. Myers, James E. Mccutcheon
No Evidence That Portion Size Influences Food Consumption In Male Sprague Dawley Rats, Fabien Naniex, Sophie C. Pinder, Megan Y. Summers, Renee M. Rouleau, Eric Robinson, Kevin P. Myers, James E. Mccutcheon
Faculty Journal Articles
In studies of eating behavior that have been conducted in humans, the tendency to consume more when given larger portions of food, known as the portion size effect (PSE), is one of the most robust and widely replicated findings. Despite this, the mechanisms that underpin it are still unknown. In particular, it is unclear whether the PSE arises from higher-order social and cognitive processes that are unique to humans or, instead, reflects more fundamental processes that drive feeding, such as conditioned food-seeking. Importantly, studies in rodents and other animals have yet to show convincing evidence of a PSE. In this …
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
Legacy Theses & Dissertations (2009 - 2024)
Numerous neurodevelopmental and neuropsychiatric diseases have a distinct sex bias in
Behavioral Impairment Following Gestational Exposure To Titanium Dioxide Nanomaterial Aerosols In Male And Female Rats, Matthew Leland Eckard
Behavioral Impairment Following Gestational Exposure To Titanium Dioxide Nanomaterial Aerosols In Male And Female Rats, Matthew Leland Eckard
Graduate Theses, Dissertations, and Problem Reports
Engineered nanomaterials (ENMs) are beginning to be recognized as hazardous to human and animal health. Titanium dioxide (TiO2) is primarily used as a whitening agent in paints, plastics, and sunscreens. While relatively inert in its bulk form, nano-TiO2 (diameter) can produce prolonged inflammation and oxidative stress in target tissue. Recently, the potential for nano-TiO2 to cause neuroinflammation and damage has heightened concerns about its continued use. One important concern is that nano-TiO2, and other metal oxide ENMs, may affect fetal neurodevelopment. Accordingly, it is imperative to screen ENMs, like TiO2, for possible neurotoxicity following developmental exposures. The current set of …