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Prospective Associations Of Homocysteine, Executive Function, And Depressive Symptoms, Peter J. Dearborn

Electronic Theses and Dissertations

Associations of cardiovascular risk factors, cognitive performance, and depressive symptoms have been well established. However, the directionality of these associations as well as the specificity of these associations with respect to executive function are less clear. Additionally few studies have determined whether genetic risk factors, such as apolipoprotein-E4 (APOE-E4) genotype, and age moderate the associations of cardiovascular risk factors such as homocysteine with changes in depressive symptoms and how these associations may be mediated by cognitive performance. The primary aim of this study was to analyze the bidirectional associations of a full range of cognitive domains and symptoms of depression …

Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins

Theses and Dissertations

The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …

Association Between Latent Toxoplasma Gondii Infection And Alzheimer's Disease, Cynthia Elizabeth Wyman

Theses and Dissertations

Introduction: Many studies have found an association between Toxoplasma gondii seropositivity and behavioral and cognitive changes in animal models and in humans. In addition, early findings have suggested an association between T. gondii seropositivity and Alzheimer's disease (AD). We sought to determine whether there is an association between T. gondii seropositivity and AD as well as cognitive functioning (including memory, working memory, processing speed, language functioning, executive functioning) in a large, well-characterized sample of subjects with AD and matched controls without dementia. Method: Using ELISA assays, we determined anti-T. gondii IgG antibody titers in 114 control subjects and in 105 …

Association Between Latent Toxoplasma Gondii Infection And Alzheimer's Disease, Cynthia Elizabeth Wyman

Theses and Dissertations

Introduction: Many studies have found an association between Toxoplasma gondii seropositivity and behavioral and cognitive changes in animal models and in humans. In addition, early findings have suggested an association between T. gondii seropositivity and Alzheimer's disease (AD). We sought to determine whether there is an association between T. gondii seropositivity and AD as well as cognitive functioning (including memory, working memory, processing speed, language functioning, executive functioning) in a large, well-characterized sample of subjects with AD and matched controls without dementia. Method: Using ELISA assays, we determined anti-T. gondii IgG antibody titers in 114 control subjects and in …

Life-Long Creativity: Changing The Narrative Of Aging And Retirement, Jennifer K. Gippel Dr

Creativity and Change Leadership Graduate Student Master's Projects

The current narratives and stereotypes around retirement and aging are both inaccurate and incomplete. The popular media regularly portrays retirees and older citizens as blissfully happy but bland; or physically feeble and forgetful. Rarely are they portrayed as achievers and vibrant problem solvers. Instead they are perceived by policy makers as a problem to be solved. This project offers a different narrative ― one that presents retirement and aging as a unique time of creative opportunity, possibility, and freedom to choose. The primary outcome of the project is two chapters of a book entitled: Retirement by design: How to discover …

Combined Mnemonic Strategy Training And High-Definition Transcranial Direct Current Stimulation For Memory Deficits In Mild Cognitive Impairment, Benjamin M. Hampstead, Krishnankutty Sathian, Marom Bikson, Anthony Y. Stringer

Publications and Research

Introduction: Memory deficits characterize Alzheimer’s dementia and the clinical precursor stage known as mild cognitive impairment. Nonpharmacologic interventions hold promise for enhancing functioning in these patients, potentially delaying functional impairment that denotes transition to dementia. Previous findings revealed that mnemonic strategy training (MST) enhances long-term retention of trained stimuli and is accompanied by increased blood oxygen level–dependent signal in the lateral frontal and parietal cortices as well as in the hippocampus. The present study was designed to enhance MST generalization, and the range of patients who benefit, via concurrent delivery of transcranial direct current stimulation (tDCS).

Methods: This protocol describes …

Age Differences In Stress And Coping: Problem-Focused Strategies Mediate The Relationship Between Age And Positive Affect, Yiwei Chen, Yisheng Peng, Huanzhen Xu, William H. O'Brien

Psychology Faculty Publications

The present study examined the different types of stressors experienced by adults of different ages, their coping strategies, and positive/negative affect. A mediation hypothesis of coping strategies was tested on the relationships between age and positive/negative affect. One-hundred and ninety-six community-dwelling adults (age range 18-89 years old) reported the most stressful situation they experienced in the past month and coping strategies. Levels of positive and negative affect in the past month were also measured. Content analysis revealed age differences in different types of stressors adults reported. Three types of coping strategies were found: problem-focused, positive emotion-focused, and negative emotion-focused coping. …

Impact Of Expressive Intensity And Stimulus Location On Emotion Detection, Brittany Nicole Groh

Masters Theses & Specialist Projects

Previous research demonstrates that the age of an observer, the peripheral location of a face stimulus on a display, and the intensity of the emotion expressed by the face all play a role in emotion perception. Older individuals have more difficulty identifying emotion in faces, especially at lower expressive intensities. The purpose of the current study was to understand how younger and older adults’ abilities to detect emotion in facial stimuli presented in the periphery would be affected by the intensity of the emotional expressions and the distance that the expressions are presented away from the center of the display. …

Age-Related Differences In Context-Specificity Benefits Ambiguous Predictive Learning, Catherine Luna

Mahurin Honors College Capstone Experience/Thesis Projects

The present study investigated age differences in the context-specificity effect in learning. Ambiguity was manipulated in two conditions in a predictive learning paradigm (Callejas-Aguilera & Rosas, 2010) to encourage participants to attend to context. In the ambiguous condition, foods led to the presence of the illness equally as often as its absence. In the non-ambiguous condition, foods consistently led to the presence of the illness or consistently lead to its absence. Participants were instructed to make predictive judgments for foods leading to the presence of an illness in one of two restaurant contexts. During the test, participants made predictive judgments …

A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot

Electronic Theses, Projects, and Dissertations

As gerontologists may know, there are a great deal of studies and a variety of academic literature on the misuse of alcohol and prescription medication amongst the elderly population. While there is a plethora of information on alcohol and prescription misuse, there is little reported data about the prevalence of other substance misuse experienced by this population. This study aims to help to fill that gap in the data by using quantitative methods to describe the scope of substance abuse of individuals 55-years or older. This study utilizes data from the Treatment Data Set Admission (TEDS-A). The TEDS-A is a …

Age-Related Changes In Visual Spatial Performance, Samantha Farrell

Seton Hall University Dissertations and Theses (ETDs)

Visual spatial skills allow individuals to understand the relationship between objects, people, and the environment for their everyday activities. Visual spatial abilities incorporate visual, motor, and cognitive components, each of which changes across the lifespan. The current study examined the effects of age-related changes and practice type on visual spatial performance. Participants between 40 and 79 years of age were asked to complete the Block Design Task (BDT) by using nine blocks to recreate various designs. Both accuracy and latency were measured to examine these changes. Task difficulty and practice type were varied and cognitive abilities were measured via MMSE …

Cytomegalovirus Serostatus, Inflammation, And Antibody Response To Influenza Vaccination In Older Adults: The Moderating Effect Of Beta Blockade, Rebecca G. Reed, Richard N. Greenberg, Suzanne C. Segerstrom

Psychology Faculty Publications

Cytomegalovirus (CMV) has been implicated as a factor in immunosenescence, including poor antibody response to vaccination and higher immune activation and inflammation. Some people may be more or less vulnerable to the negative effects of CMV. The present investigation tested the effects of beta-blocker use and chronological age on the associations between CMV and immunity in adults aged 60–91 (N=98; 69% CMV seropositive) who were administered the trivalent influenza vaccine for up to 5 years. Peak antibody response, corrected for baseline, and spring (persistent) antibody response, corrected for peak, were assessed, as well as beta-2 microglobulin (β2μ) and interleukin-6 (IL-6). …

Facial Recognition And Visual Processing As We Age: Using The Thatcher Illusion With Famous And Non-Famous Faces, Richard Hicks, Victoria Alexander, Mark Bahr

Mark Bahr

This paper reports a study examining preferred visual processes in recognition of facial features in older vs younger age groups, using Thatcherised images of famous and non-famous people in the one study. The aims were to determine whether decline in visual system processing occurs increasingly as we grow older, and whether there is less decline in recognition of famous (or familiar) faces. Three groups (younger, middle-old and older) made up the sample of 73 people (aged 19-82 years). Visual decline in face recognition across the age groups was assessed based on the Thatcher illusion—using four famous and four non-famous faces …

Facial Recognition And Visual Processing As We Age: Using The Thatcher Illusion With Famous And Non-Famous Faces, Richard Hicks, Victoria Alexander, Mark Bahr

Richard Hicks

This paper reports a study examining preferred visual processes in recognition of facial features in older vs younger age groups, using Thatcherised images of famous and non-famous people in the one study. The aims were to determine whether decline in visual system processing occurs increasingly as we grow older, and whether there is less decline in recognition of famous (or familiar) faces. Three groups (younger, middle-old and older) made up the sample of 73 people (aged 19-82 years). Visual decline in face recognition across the age groups was assessed based on the Thatcher illusion—using four famous and four non-famous faces …

Adolescent Cannabinoid Exposure Induces A Persistent Sub-Cortical Hyper-Dopaminergic State And Associated Molecular Adaptations In The Prefrontal Cortex., Justine Renard, Laura G Rosen, Michael Loureiro, Cleusa De Oliveira, Susanne Schmid, Walter J Rushlow, Steven R Laviolette

Brain and Mind Institute Researchers' Publications

Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol (THC), the psychoactive component in marijuana, increases the risk of developing schizophrenia-related symptoms in early adulthood. In the present study, we used a combination of behavioral and molecular analyses with in vivo neuronal electrophysiology to compare the long-term effects of adolescent versus adulthood THC exposure in rats. We report that adolescent, but not adult, THC exposure induces long-term neuropsychiatric-like phenotypes similar to those observed in clinical populations. Thus, adolescent THC exposure induced behavioral abnormalities resembling positive and negative schizophrenia-related endophenotypes and a state of neuronal hyperactivity in the mesocorticolimbic dopamine (DA) pathway. …

Social Networks, Health & Hispanic Gay Men Living In South Florida, Victor Christian Vila

FIU Electronic Theses and Dissertations

Aging Hispanic populations are expected to increase in the United States (U.S.) to 21.5 million by 2060 according to the National Council on Aging (NCA) (2014). Although actual estimates vary, Gates (2013) asserts that over one million Hispanics identify as gay or bisexual and their unique needs must be explored (Clover, 2006; Cohn & Taylor, 2010; Fenkl, 2014). Unfortunately, few studies examine aging Hispanic men who identify as gay or bisexual according to the National Hispanic Council on Aging (NHCOA) (2013). The objective of the current study was to extend the limited research on aging gay/bisexual men in the southeastern …

Beliefs About Savoring In Older Adulthood: Aging And Perceived Health Affect Temporal Components Of Perceived Savoring Ability, Paul Jefferson Geiger, Jennifer N. Morey, Suzanne C. Segerstrom

Psychology Faculty Publications

The ability to savor positive life events is associated with higher emotional well-being; however, few studies have examined savoring ability in older adults. The present study used a longitudinal design to examine changes in perceived savoring abilities and associations with perceived health in older adulthood. Older adults (N=131) reported on beliefs about savoring and perceived health at baseline and 2½ years later. Perceived anticipation (savoring the future) and reminiscing (savoring the past) abilities declined from baseline to follow-up. Better perceived health at baseline predicted greater perceived reminiscing and anticipation abilities at follow-up. Greater perceived ability to savor the …

Motor Timing Intraindividual Variability In Amnestic Mild Cognitive Impairment And Cognitively Intact Elders At Genetic Risk For Alzheimer’S Disease, Christina D. Kay, Michael Seidenberg, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, John L. Woodard, Stephen M. Rao

Psychology Faculty Research and Publications

Introduction: Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT).

Method: Two Alzheimer’s disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 noncarriers ( …

Optimism And Pain Interference In Aging Women, Stephanie T. Judge

Theses and Dissertations--Psychology

Pain interferes with people's daily lives and often limits the extent to which they can pursue goals and engages in activities that promote well-being. The present study test how optimism affects and is affected by pain interference and activity among older women. Every three months for two years, middle- and older-age women (N = 199) complete daily diaries at home for a seven-day period, reporting their daily pain, pain interference, and activity. Optimism was measured at baseline and end-of-study. Multilevel models test the between- and within-person relationships among pain, optimism, pain interference and activity. Pain best predicted pain interference …

Testing A Values-Based Approach To Healthcare Decision-Making In Older Adults, Paul Jefferson Geiger

Theses and Dissertations--Psychology

Despite natural declines in physical and cognitive function, older adults maintain good emotion regulation abilities, leading to emotional wellbeing and resilience. This phenomenon can partially be explained by socioemotional selectivity theory (SST), which posits that when time is perceived as a limited resource, older adults focus attention on positive environmental stimuli to regulate emotions. Although this positivity effect maintains emotional wellbeing, it may disrupt information processing related to healthcare decision-making. Older adults request less information from their doctors, are less likely to ask for a second opinion, make their decisions more quickly, and devote more attention to positive medical information, …

Maintenance Of Positive Affect Following Pain In Younger And Older Adults, Ian Andres Boggero

Theses and Dissertations--Psychology

Socioemotional selectivity theory posits that as people age, they become motivated and successful at maximizing positive emotions and minimizing negative ones. Yet, 70% of older adults report physical pain, which is associated with negative affect. The strategies and resources that older adults use to maintain positive affect in the face of pain remain largely unknown. Specific positivity-enhancing strategies include recalling, recognizing, and responding to positive stimuli and prioritizing close over knowledgeable social partners. Executive functions (EF, i.e., task-switching, working memory, and inhibition) and heart rate variability (HRV) may be important resources for coping with pain. The current project used two …

That Note Sounds Wrong! Age-Related Effects In Processing Of Musical Expectation, Andrea R. Halpern, Ioanna Zioga, Martin Shankleman, Job Lindsen, Marcus T. Pearce, Joydeep Bhattacharya

Faculty Journal Articles

Part of musical understanding and enjoyment stems from the ability to accurately predict what note (or one of a small set of notes) is likely to follow after hearing the first part of a melody. Selective violation of expectations can add to aesthetic response but radical or frequent violations are likely to be disliked or not comprehended. In this study we investigated whether a lifetime of exposure to music among untrained older adults would enhance their reaction to unexpected endings of unfamiliar melodies. Older and younger adults listened to melodies that had expected or unexpected ending notes, according to Western …

Aging Is In The Eye Of The Beholder: Eye-Tracking And Person-Perception Analyses Of Young And Old Faces, Stephanie M. Ha

Honors Theses

To examine possible mechanisms related to negative attitudes of aging revealed in face processing patterns, young and old participants rated their first impressions (positive or negative) of 100 faces of young and old individuals taken from the CAL/PAL Fate Database (Minear & Park, 2004) while gaze patterns were recorded using eye-tracking methods. In a follow-up study, an independent sample of young participants rated the same 100 faces on competence, attractiveness, and subjective age in order to further assess age-related stereotypes. This study replicated the T-gaze pattern in previous eye-tracking studies (Firestone, Turk, Browne, & Ryan 2007). We also found evidence …

The Relationship Between Family Support; Pain And Depression In Elderly With Arthritis, Wendy C. Birmingham, Man Hung, Jerry Bounsanga, Maren W. Voss, Anthony B. Crum, Wei Chen

Faculty Publications

The prevalence and chronic nature of arthritis make it the most common cause of disability among U.S.A adults. Family support reduces the negative impact of chronic conditions generally but its role in pain and depression for arthritic conditions is not well understood. A total of 844 males (35.0%) and 1567 females (65.0%) with arthritic conditions (n = 2411) were drawn from the 2012 Health and Retirement Study to examine the effect of family support on pain and depressive symptoms. Using regression analysis and controlling for age, ethnicity, gender, marital/educational status and employment/income, physical function/disability status, pain and antidepressant medications, and …