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Sleight Of Hand: Role-Differentiated Bimanual Manipulation Speed Across Infancy, Julie M. Campbell, Emily C. Marcinowski

Faculty Publications – Psychology

Role-differentiated bimanual manipulation (RDBM) is a complex behaviour requiring the complementary movement of two hands to achieve a common goal. We investigated the relation of RDBM speed (time to complete a successful RDBM) with a hand preference for acquiring objects (early right, late right, left, no preference), toy type (simple/difficult), age (9-14 months), and hand (right/left) used to perform the RDBM. Changes in RDBM speed across age were examined across different hand preference groups for RDBMs performed on simple toys using the right hand. The analysis revealed that early-right preference infants had a steeper slope than the no preference/left-preference infants. …

Profile Of Autism Spectrum Disorder In Tuberous Sclerosis Complex: Results From A Longitudinal, Prospective, Multisite Study, Jamie K Capal, Marian E Williams, Deborah A Pearson, Robin Kissinger, Paul S Horn, Donna Murray, Kristn Currans, Bridget Kent, Martina Bebin, Hope Northrup, Joyce Y Wu, Mustafa Sahin, Darcy A Krueger, Tacern Study Group

Student and Faculty Publications

OBJECTIVE: Tuberous sclerosis complex (TSC) is highly associated with autism spectrum disorder (ASD). Objectives of the study were to characterize autistic features in young children with TSC.

METHODS: Participants included 138 children followed from ages 3 to 36 months with TSC from the Tuberous Sclerosis Complex Autism Center of Excellence Research Network (TACERN), a multicenter, prospective observational study aimed at understanding the underlying mechanisms of ASD in TSC. Developmental and autism-specific assessments were administered, and a clinical diagnosis of ASD was determined for all participants at 36 months. Further analyses were performed on 117 participants with valid autism assessments based …

Population-Based Approaches For Monitoring The Nurturing Care Environment For Early Childhood Development: A Scoping Review, Jéssica Pedroso, Stefanie Eugênia Dos Anjos Coelho Kubo, Priscila Olin Silva, Gabriel Ferreira De Castro, Juliana Lopes Pimentel, Rafael Pérez-Escamilla, Muriel Bauermann Gubert, Gabriela Buccini

Social & Behavioral Health Faculty Publications

Selecting indicators to monitor nurturing care (NC) environments that support decision-making and guide the implementation of integrated early childhood development (ECD) programmes has become a priority globally. Several population-based approaches have been attempted to create a set of indicators or a composite index methodology to measure the NC environment using existing secondary data. However, they have not been systematized. Our scoping review aimed to analyse the population-based approaches for monitoring the domains of the NC (e.g. good health, adequate nutrition, responsive caregiving, security and safety, and opportunities for early learning). ECD experts, peer-reviewed, and grey literature were systematically searched with …

The Relationship Between Infant-Family Routines, Number Of Caregivers And Infant Basal Cortisol, Vanessa Newell, Hannah B. White

Undergraduate Research Symposium

Background: Family routines have been found to be related to child adjustment, marital satisfaction, and parenting competence (Fiese, 2002). Persistent stress, and the resulting frequent activation of the body’s stress responses, can result in excessive wear-and-tear on the body and brain known as allostatic load (McEwen, 2000). In infants, basal cortisol levels act as an instrument to measure allostatic load (White, 2020). To our knowledge, no existing work on the impact of routines on infant development has examined the role of family structure. In traditional and minority cultures it is common for caregiving responsibilities to be divided among multiple individuals. …

Investigating Developmental Changes In Scalp-To-Cortex Correspondence Using Diffuse Optical Tomography Sensitivity In Infancy, Xiaoxue Fu, John E. Richards

Faculty Publications

Significance: Diffuse optical tomography (DOT) uses near-infrared light spectroscopy (NIRS) to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of NIRS data require accurate descriptions of the cranio-cerebral relations and DOT sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development.

Aim: We aim to investigate age-related differences in scalp-to-cortex distance and mapping between scalp locations and cortical regions of interest (ROIs) among infants (2 weeks to 24 months with narrow age bins), children (4 and 12 years), and adults (20 to 24 years).

Approach: We …

Structural Templates For Imaging Eeg Cortical Sources In Infants, Christian O'Reilly, Eric Larson, J. E. Richards, Mayada Elsabbagh

Faculty Publications

Electroencephalographic (EEG) source reconstruction is a powerful approach that allows anatomical localization of electrophysiological brain activity. Algorithms used to estimate cortical sources require an anatomical model of the head and the brain, generally reconstructed using magnetic resonance imaging (MRI). When such scans are unavailable, a population average can be used for adults, but no average surface template is available for cortical source imaging in infants. To address this issue, we introduce a new series of 13 anatomical models for subjects between zero and 24 months of age. These templates are built from MRI averages and boundary element method (BEM) segmentation …

Neural Responses To Happy, Fearful And Angry Faces Of Varying Identities In 5-And 7-Month-Old Infants, Laurie Bayet, Katherine L. Perdue, Hannah F. Behrendt, John E. Richards, Alissa Westerlund, Julia K. Cataldo, Charles A. Nelson Iii

Faculty Publications

The processing of facial emotion is an important social skill that develops throughout infancy and early childhood. Here we investigate the neural underpinnings of the ability to process facial emotion across changes in facial identity in cross-sectional groups of 5- and 7-month-old infants. We simultaneously measured neural metabolic, behavioral, and autonomic responses to happy, fearful, and angry faces of different female models using functional near-infrared spectroscopy (fNIRS), eye-tracking, and heart rate measures. We observed significant neural activation to these facial emotions in a distributed set of frontal and temporal brain regions, and longer looking to the mouth region of angry …

Improving Breastfeeding Environments And Feeding Practices In Family Child Care Homes With The Go Nap Sacc Program, Kara Kohel, Holly Hatton-Bowers, Natalie A. Williams, Dipti Dev, Donnia Behrends, Emily Hulse, Zainab Rida, Holly Dingman, Danae Dinkel, Liz Gebhart

Department of Child, Youth, and Family Studies: Faculty Publications

Purpose: Breastfeeding and responsive feeding are important practices that support the health of infants and women. In the United States, breastfeeding continuation rates remain lower than recommended, and working women face additional challenges with breastfeeding continuation. Providers in a family child care setting are uniquely positioned to support and provide important resources to families in their breastfeeding and infant feeding practices.

Methods: The Go NAP SACC program was designed to improve the nutrition and physical activity environments and practices in child care settings serving infants and young children. This evaluation focuses on Breastfeeding and Infant Feeding in Nebraska Family Child …

Nonsuicidal Self-Injury, Suicide Planning, And Suicide Attempt Among High-Risk Adolescents Prior To Psychiatric Hospitalization, Christina M. Sellers, Antonia Díaz-Valdés, Andrew C. Porter, Catherine R. Glenn, Adam Bryant Miller, Adeline Wyman Battalen, Kimberly H. Mcmanama O'Brien

Psychology Faculty Publications

The purpose of this study was to understand the trajectories of nonsuicidal self-injury (NSSI) and suicide plans (SP) in the 90 days prior to inpatient hospitalization, understand the role of NSSI and SP in predicting suicide attempts (SA) on a given day, and to test the interaction between NSSI and SP in predicting same-day SA. Participants included 69 adolescents (77% female, 65% white, 77% Non-Hispanic/Latinx, Mage = 15.77 SDage = 1.00) from an inpatient psychiatric unit. Past 90 day NSSI, SP, and SA were measured using the Columbia Suicide Severity Rating Scale and Timeline Follow Back. First, mixed effect models …

Parent-Infant Relationships, Lisa Babel

Open Educational Resources

No abstract provided.

Neural Processing Of Infant And Adult Face Emotion And Maternal Exposure To Childhood Maltreatment, Aviva K. Olsavsky, Joel Stoddard, Andrew Erhart, Rebekah C. Tribble, Pilyoung Kim

Psychology: Faculty Scholarship

Face processing in mothers is linked to mother–infant social communication, which is critical for parenting and in turn for child development. Neuroimaging studies of child maltreatment-exposed (CME) mothers are sparse compared to studies of mothers with postpartum depression, which have suggested blunted amygdala reactivity to infant stimuli. We expected to see a similar pattern in CME mothers. Based on broader studies in trauma-exposed populations, we anticipated increased amygdala reactivity to negative adult face stimuli in a comparison task in CME mothers given heightened evaluation of potential threat. We examined Neuroimaging studies of mothers with childhood maltreatment exposure (CME) (18–37 years …

The Emergence Of Top-Down, Sensory Prediction During Learning In Infancy: A Comparison Of Full-Term And Preterm Infants, Alex M. Boldin, Romin Geiger, Lauren L. Emberson

Psychology Student Research

Prematurity alters developmental trajectories in preterm infants even in the absence of medical complications. Here, we use fNIRS and learning tasks to probe the nature of the developmental differences between preterm and full-term born infants. Our recent work has found that prematurity disrupts the ability to engage in top-down sensory prediction after learning. We now examine the neural changes during the learning that precede prediction. In full-terms, we found modulation of all cortical regions examined during learning (temporal, frontal, and occipital). By contrast, preterm infants had no evidence of neural changes in the occipital lobe selectively. This is striking as …

Nutrient Intake In The First Two Weeks Of Life And Brain Growth In Preterm Neonates., Juliane Schneider, Céline J Fischer Fumeaux, Emma G Duerden, Ting Guo, Justin Foong, Myriam Bickle Graz, Patric Hagmann, M Mallar Chakravarty, Petra S Hüppi, Lydie Beauport, Anita C Truttmann, Steven P Miller

Brain and Mind Institute Researchers' Publications

BACKGROUND: Optimizing early nutritional intake in preterm neonates may promote brain health and neurodevelopment through enhanced brain maturation. Our objectives were (1) to determine the association of energy and macronutrient intake in the first 2 weeks of life with regional and total brain growth and white matter (WM) maturation, assessed by 3 serial MRI scans in preterm neonates; (2) to examine how critical illness modifies this association; and (3) to investigate the relationship with neurodevelopmental outcomes.

METHODS: Forty-nine preterm neonates (21 boys, median [interquartile range] gestational age: 27.6 [2.3] weeks) were scanned serially at the following median postmenstrual weeks: 29.4, …

Development Of Body Emotion Perception In Infancy: From Discrimination To Recognition, Alison Heck, Alyson Chroust, Hannah B. White, Rachel Lynn Jubran, Ramesh S. Bhatt

Psychology Faculty Publications

Research suggests that infants progress from discrimination to recognition of emotions in faces during the first half year of life. It is unknown whether the perception of emotions from bodies develops in a similar manner. In the current study, when presented with happy and angry body videos and voices, 5-month-olds looked longer at the matching video when they were presented upright but not when they were inverted. In contrast, 3.5-month-olds failed to match even with upright videos. Thus, 5-month-olds but not 3.5-month-olds exhibited evidence of recognition of emotions from bodies by demonstrating intermodal matching. In a subsequent experiment, younger infants …

Visual Scanning Of Males And Females In Infancy, Hannah B. White, Alyson J. Hock, Rachel L. Jubran, Alison Heck, Ramesh S. Bhatt

Psychology Faculty Publications

This study addressed the development of attention to information that is socially relevant to adults by examining infants' (n = 64) scanning patterns of male and female bodies. Infants exhibited systematic attention to regions associated with sex-related scanning by adults, with 3.5-and 6.5-month-olds looking longer at the torso of females than males and longer at the legs of males than females. However, this pattern of looking was not found when infants were tested on headless bodies in Experiment 2, which suggests that infants' differential gaze pattern in Experiment 1 was not due to low-level stimulus features, such as clothing, and …

Early Procedural Pain Is Associated With Regionally-Specific Alterations In Thalamic Development In Preterm Neonates., Emma G Duerden, Ruth E Grunau, Ting Guo, Justin Foong, Alexander Pearson, Stephanie Au-Young, Raphael Lavoie, M Mallar Chakravarty, Vann Chau, Anne Synnes, Steven P Miller

Brain and Mind Institute Researchers' Publications

Very preterm human neonates are exposed to numerous invasive procedures as part of life-saving care. Evidence suggests that repetitive neonatal procedural pain precedes long-term alterations in brain development. However, to date the link between pain and brain development has limited temporal and anatomic specificity. We hypothesized that early exposure to painful stimuli during a period of rapid brain development, before pain modulatory systems reach maturity, will predict pronounced changes in thalamic development, and thereby cognitive and motor function. In a prospective cohort study, 155 very preterm neonates (82 males, 73 females) born 24-32 weeks' gestation underwent two MRIs at median …

A New Model Of Wheezing Severity In Young Children Using The Validated Isaac Wheezing Module: A Latent Variable Approach With Validation In Independent Cohorts., Steven M. Brunwasser Phd, Tebeb Gebretsadik, Diane R Gold, Kedir N Turi, Cosby A Stone, Soma Datta, James E Gern, Tina V Hartert

College of Science & Mathematics Departmental Research

BACKGROUND: The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) consortium. However, there is no consensus model for operationalizing wheezing severity with this instrument in explanatory research studies. Severity is typically measured using coarsely-defined categorical variables, reducing power and potentially underestimating etiological associations. More precise measurement approaches could improve testing of etiological theories of wheezing illness.

METHODS: We evaluated a continuous latent variable model of pediatric wheezing severity based on four ISAAC …

Validation Of Vulnerability Markers Of Dysfunctions In The Socioemotional Development Of Infants, Daniel Ignacio Da Silva, Débora Falleiros De Mello, Renata Ferreira Takahashi, Cody S. Hollist, Verônica De Azevedo Mazza, Maria De La Ó Ramallo Veríssimo

Department of Child, Youth, and Family Studies: Faculty Publications

No abstract provided.

Quantitative Assessment Of White Matter Injury In Preterm Neonates: Association With Outcomes., Ting Guo, Emma G Duerden, Elysia Adams, Vann Chau, Helen M Branson, M Mallar Chakravarty, Kenneth J Poskitt, Anne Synnes, Ruth E Grunau, Steven P Miller

Brain and Mind Institute Researchers' Publications

OBJECTIVE: To quantitatively assess white matter injury (WMI) volume and location in very preterm neonates, and to examine the association of lesion volume and location with 18-month neurodevelopmental outcomes.

METHODS: Volume and location of WMI was quantified on MRI in 216 neonates (median gestational age 27.9 weeks) who had motor, cognitive, and language assessments at 18 months corrected age (CA). Neonates were scanned at 32.1 postmenstrual weeks (median) and 68 (31.5%) had WMI; of 66 survivors, 58 (87.9%) had MRI and 18-month outcomes. WMI was manually segmented and transformed into a common image space, accounting for intersubject anatomical variability. Probability …

He’S Just Content To Sit: A Qualitative Study Of Mothers’ Perceptions Of Infant Obesity And Physical Activity, Danae Dinkel, Kailey Snyder, Anastasia Kyvelidou, Victoria Molfese

Department of Child, Youth, and Family Studies: Faculty Publications

Background: Rates of obesity among children ages zero to five are rapidly increasing. Greater efforts are needed to promote healthy behaviors of young children. Mothers are especially important targets for promoting health as mothers’ views play a vital role in helping their children foster healthy habits from an early age. Research has found parents’ views of infants’ weight may influence their feeding practices; however, limited research has explored mothers’ view of infants’ weight in relation to the promotion of physical activity. Therefore, the purpose of this study was to explore the perceptions of mothers of normal weight infants and overweight …

Attune With Baby: An Innovative Attunement Program For Parents And Families With Integrated Evaluation, Sara Beth Lohre

Antioch University Dissertations & Theses

Infants speak in their own language; sounds, screeches, cries, and howls that help them to communicate their caregiving needs. Unaware, parents may develop a checklist of caregiving approaches to the baby. The infant tells the adult directly what they need, and waits for the parent to respond. Infant talk may change from soft and quiet to loud and aggressive; coos and cries become crying and screams as the infant’s caregiver—communicating the intensity of emotion, urgency of their request, or their frustration with varied and sometimes inadequate, failed, or missing caregiving patterns the infant has no choice but to accept. When …

Infant Language Assessment Predicts Later Math Disabilities, Aaron T. Halvorsen, Dennis Molfese

UCARE Research Products

Prevention of cognitive disabilities currently remains out of reach. Yet, interventions are crucial to maximizing developmental outcomes later in life. To be effective, interventions must occur at the earliest age possible to mitigate potential developmental problems. This study is an attempt to identify newborn infants at risk for developing math disabilities later in life. Several studies used assessment tests at relatively late ages in order to predict future cognitive abilities (Aarnoudse-Moens et al., 2013; Kiechl-Kohlendorfer et al., 2013). More recent research used MRI scans of neonate brains to investigate the relationships between academic abilities and preterm births (Ullman et al., …

Maternal Postsecondary Education Associated With Improved Cerebellar Growth After Preterm Birth., Mikaela L Stiver, Daphne Kamino, Ting Guo, Angela Thompson, Emma G Duerden, Margot J Taylor, Emily W Y Tam

Brain and Mind Institute Researchers' Publications

The preterm cerebellum is vulnerable to impaired development impacting long-term outcome. Preterm newborns (<32 >weeks) underwent serial magnetic resonance imaging (MRI) scans. The association between parental education and cerebellar volume at each time point was assessed, adjusting for age at scan. In 26 infants, cerebellar volumes at term (P = .001), but not birth (P = .4), were associated with 2-year volumes. For 1 cm(3) smaller cerebellar volume (4% total volume) at term, the cerebellum was 3.18 cm(3) smaller (3% total volume) by 2 years. Maternal postsecondary education was not associated with cerebellar volume at term (P = .16). Maternal …

Tract-Based Spatial Statistics In Preterm-Born Neonates Predicts Cognitive And Motor Outcomes At 18 Months., E G Duerden, J Foong, V Chau, H Branson, K J Poskitt, R E Grunau, A Synnes, J G Zwicker, S P Miller

Brain and Mind Institute Researchers' Publications

BACKGROUND AND PURPOSE: Adverse neurodevelopmental outcome is common in children born preterm. Early sensitive predictors of neurodevelopmental outcome such as MR imaging are needed. Tract-based spatial statistics, a diffusion MR imaging analysis method, performed at term-equivalent age (40 weeks) is a promising predictor of neurodevelopmental outcomes in children born very preterm. We sought to determine the association of tract-based spatial statistics findings before term-equivalent age with neurodevelopmental outcome at 18-months corrected age.

MATERIALS AND METHODS: Of 180 neonates (born at 24-32-weeks' gestation) enrolled, 153 had DTI acquired early at 32 weeks' postmenstrual age and 105 had DTI acquired later at …

Comparison Of Cortisol Samples In The First Two Weeks Of Life In Preterm Infants, Tiffany A. Moore, Kendra K. Schmid, Jeffrey French

Psychology Faculty Publications

Background: Growing literature on negative childhood stress emphasizes the need to understand cortisol values from varying biomarker samples.

Objective: This work aimed to examine cortisol samples for usability, associations, and individual stability in neonates.

Subjects: The sample consisted of preterm infants (n=31).

Materials and methods: Analyses on cortisol collected from cord blood and from saliva and urine samples on days 1, 7, and 14 included Spearman correlations and paired t-tests.

Results: Usability rates were 80.6% (cord blood), 85.9% (saliva), and 93.5% (urine). Salivary and urinary cortisol levels had significant correlation on day 1 only (p=0.004). Significant differences in individual stability …

Automatic Segmentation Of The Hippocampus For Preterm Neonates From Early-In-Life To Term-Equivalent Age., Ting Guo, Julie L Winterburn, Jon Pipitone, Emma G Duerden, Min Tae M Park, Vann Chau, Kenneth J Poskitt, Ruth E Grunau, Anne Synnes, Steven P Miller, M Mallar Chakravarty

Brain and Mind Institute Researchers' Publications

INTRODUCTION: The hippocampus, a medial temporal lobe structure central to learning and memory, is particularly vulnerable in preterm-born neonates. To date, segmentation of the hippocampus for preterm-born neonates has not yet been performed early-in-life (shortly after birth when clinically stable). The present study focuses on the development and validation of an automatic segmentation protocol that is based on the MAGeT-Brain (Multiple Automatically Generated Templates) algorithm to delineate the hippocampi of preterm neonates on their brain MRIs acquired at not only term-equivalent age but also early-in-life.

METHODS: First, we present a three-step manual segmentation protocol to delineate the hippocampus for preterm …

Factors That Affect Attachment Between The Employed Mother And The Child, Infancy To Two Years, Naureen Kassamali, Salma Amin Rattani

School of Nursing & Midwifery

To explore a mother's feeling of attachment and the affects her working status on the attachment relationship with her child, upon ethical clearance from the institutional ethics committee, in-depth interviews of nine participants were conducted. Mothers enrolled were those who resumed the employment within the first year of post-delivery and were having a child up to two years of age. Results revealed that maternal employment itself does not enhance or deteriorate attachment with the child. It is combinations of factors that revolve around it impact on their bond. Overall, maternal integration or the balance of the dual roles of employment …

The Serotonin Transporter Gene Linked Polymorphic Region Is Associated With The Behavioral Response To Repeated Stress Exposure In Infant Rhesus Macaques, Simona Spinelli, Melanie L. Schwandt, Stephen G. Lindell, Markus Heilig, Stephen J. Suomi, James Dee Higley, David Goldman, Christina S. Barr

Faculty Publications

The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5- HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across …

Neural Responses To Infants Linked With Behavioral Interactions And Testosterone In Fathers, Patty X. Kuo, Joshua Carp, Kathleen C. Light, Karen M. Grewen

Department of Child, Youth, and Family Studies: Faculty Publications

Few fMRI studies have investigated the brain-behavioral basis of parenting in human fathers. Ten fathers were videotaped and gave salivary testosterone samples while interacting with their 2–4 month old infants, and viewed video clips of their own infant and an unfamiliar age-, ethnicityand sex-matched other infant during an fMRI protocol. Infant stimuli activated a network of prefrontal and subcortical brain regions. Furthermore, a subset of these regions activated significantly more to own (OWN) than other (OTHER) infants. Finally, neural responses to OWN versus OTHER were linked with paternal sensitivity, paternal reciprocity, and testosterone. In sum, our results provide a novel …

Infant Responding To Joint Attention, Executive Processes, And Self-Regulation In Preschool Children, Amy V. Van Hecke, Peter Mundy, Jessica J. Block, Christine E.F. Delgado, Meaghan Venezia Parlade, Yuly B. Pomares, Jessica A. Hobson

Psychology Faculty Research and Publications

Infant joint attention is related to behavioral and social outcomes, as well as language in childhood. Recent research and theory suggests that the relations between joint attention and social–behavioral outcomes may reflect the role of executive self-regulatory processes in the development of joint attention. To test this hypothesis two studies were conducted. The first, cross-sectional study examined the development of responding to joint attention (RJA) skill in terms of increasing executive efficiency of responding between 9 and 18 months of age. The results indicated that development of RJA was characterized by a decreased latency to shift attention in following another …