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The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber
The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber
Wayne State University Dissertations
In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat …
A Daily Study Of The Sleep-Pain Relationship In Fibromyalgia, Maren Elizabeth Hyde-Nolan
A Daily Study Of The Sleep-Pain Relationship In Fibromyalgia, Maren Elizabeth Hyde-Nolan
Wayne State University Dissertations
Fibromyalgia (FM) impacts millions of individuals around the world and is characterized by widespread chronic pain and tenderness as well as nonrestorative sleep, fatigue, and stiffness (Wolfe et al., 1990; Wolfe et al., 2010). Poor sleep quality is reported by more than 90% of individuals with FM, suggesting that sleep disturbance may be a contributing factor to the pain experience (Moldofsky, 2008). Recent reviews of the literature have established the connection between sleep and pain, although the direction of this relationship remains unclear (Finan et al., 2013; Moldofsky, 2001). This dissertation sought to examine the daily relationship between sleep and …
Does Empathy Promote Emotion Regulation In The Context Of Pain? An Experimental Investigation, Laura E. M. Leong
Does Empathy Promote Emotion Regulation In The Context Of Pain? An Experimental Investigation, Laura E. M. Leong
Wayne State University Dissertations
The purpose of this study was to determine the extent to which a perspective-taking instruction would promote empathic behaviors in couples, resulting in better emotion regulation and greater pain tolerance during a cold pressor task. Based on empathy and intimacy theories, it was expected that observers who were instructed to take the perspective of their partner would feel and express more empathy, and that their partners would have better pain and pain tolerance compared to a control group. A sample of 128 undergraduate romantic couples participated where one partner was randomly assigned to complete the cold pressor task while the …
The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz
The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz
Wayne State University Dissertations
The amygdala processes stimuli that threaten an individual and organizes the execution of affective behaviors designed to cope with the threat. The prototypical threat to an individual is exposure to a noxious stimulus. The central nucleus of the amygdala (CeA) receives nociceptive afferents and exhibits neuronal activation in response to noxious peripheral stimulation. NMDA receptors within CeA mediate this noxious-evoked neural excitation, and previous studies in the laboratory have shown that blockade of CeA NMDA receptors via the antagonist APV elevates the threshold for noxious tail-shock-induced vocalization afterdischarges (VADs), a validated measure of pain affect in the rat. The present …