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Neural Hyperactivity During Value-Based Decision-Making In People With Daily/Near Daily Cannabis Use, Miranda Ramirez

Theses and Dissertations--Psychology

Value-based decision-making involves the coordinated effort of multiple brain regions to guide future choices based on past experiences. These processes are disrupted in cannabis use disorder, where individuals continue to use cannabis despite negative consequences. Reinforcement learning (RL) paradigms can be used to capture changes in the value of available options and may inform how the brain is impacted by frequent cannabis use. This study combined fMRI with behavioral modeling of probabilistic choice task data to compare value-based choices between young adults reporting daily/near daily cannabis use (CAN) and controls (CTRL). Participants selected one of two options reinforced ($0.25) at …

Characterizing Resting Cerebral Blood Flow In Obsessive-Compulsive Disorder With Arterial Spin Labeling, Hannah R. Wild

Theses and Dissertations--Psychology

Obsessive-compulsive disorder (OCD) is a condition characterized by intrusive thoughts (obsessions) and ritualistic behaviors (compulsions) profoundly impacting daily functioning and quality of life. Neuroimaging studies using various techniques have revealed inconsistent resting cerebral blood flow (rCBF) patterns in OCD patients, particularly within the cortico-striatal-thalamo-cortical (CSTC) circuit and sensorimotor network. Arterial Spin Labeling (ASL) MRI offers a promising, noninvasive method for directly measuring rCBF. This study, using data from the Yale HCP Trio study, analyzed unmedicated OCD patients and healthy controls, who underwent two consecutive resting pulsed-ASL scans. OCD patients with lower obsessional severity exhibited higher perfusion in the pre- and …

It Takes A Village: Impact Of Lgbtq+ Community On The Relationship Between Parenting Stress, Parent Mental Health, And Child Adjustment, Kevin Mcaweeney

Theses and Dissertations--Psychology

While LGBTQ+ parented families are largely the same as their cis-het parent counterparts, they still experience unique factors exclusive to them. One such factor is access to the LGBTQ+ community. While research has emphasized the importance of community within the family system, the role the LGBTQ+ community can play for LGBTQ+ parented families is largely unexplored. Additionally, LGBTQ+ research examining parents of adolescents is similarly lacking. Utilizing a sample of LGBTQ+ parents with adolescent children, and informed by ecological systems theory, self-determination theory, and the parenting stress model, I examine the influence parent’s sense of LGBTQ+ community has on the …

The 1-Back Matching/Mismatching Paradigm With Pigeons (Columba Livia): Evidence For Explicit Learning?, Daniel Peng

Theses and Dissertations--Psychology

With humans, a distinction can be made between explicit and implicit learning. language can be used to describe rule-based learning commonly seen in explicit, but not implicit learning. Unfortunately, we cannot do so with animals. Therefore, a non-verbal paradigm is needed to differentiate the types of learning. One method to make such a distinction is by training animals under a conditional discrimination task such as matching-to-sample with reinforcement delayed until a choice is made on the next trial: otherwise known as a 1-back procedure. In this experiment an alternating matching/mismatching to sample task under a 1-back schedule of reinforcement was …

Influence Of Oral Contraceptives On Alcohol Use In Young Adult Women, Ashley Strzelecki

Theses and Dissertations--Psychology

Rates of heavy drinking and Alcohol Use Disorder are rising dramatically in young adult women, making it important to better understand female-specific risks for problematic drinking. Circulating levels of ovarian hormones are one potential mechanism influencing alcohol use in women. Many young adult women use oral contraceptives (OCs) that alter endogenous hormone levels, and little is known about how OCs and the synthetic hormones they contain may influence alcohol use. This dissertation consists of three studies that investigated alcohol consumption in women using OCs and explored potential mechanisms through which OCs may influence alcohol use. Study 1 compared self-reported alcohol …

Body-Based Harassment And Eating Disorder Symptomology In Cisgender, Transgender, And Gender Nonconforming Individuals, Sharla D. Biefield

Theses and Dissertations--Psychology

Past research estimates that over 60% of adolescents and young adults report eating disorder symptomology (EDS), increasing their risk for psychiatric and physical comorbidities, substance abuse, and self-harm. EDS rates are also higher among transgender and gender nonconforming (TGNC) individuals. TGNC individuals also experience higher rates of bias-based harassment, than their cisgender peers. Much of this harassment is body-based harassment (BBH), such that the harassment often targets aspects of an individual’s body. The current study utilized a pantheoretical framework, incorporating minority stress theory and objectification theory, and a multi-method approach to investigate (1) if BBH increases TGNC individuals’ risk for …

Longitudinal Perspectives On Individual Outcomes, Family Functioning, And Social Support Among Diverse Adoptive Families, Emily Lapidus

Theses and Dissertations--Psychology

Given that family processes change when a child enters adolescence, it is imperative for research to utilize longitudinal analyses to capture a family unit’s development over time. This research is especially lacking amongst diverse families, such as those formed utilizing adoption or headed by same-gender parents. Utilizing both the Parenting Stress Model and Family Systems Theory, it has been shown that family dynamics are key indicators when predicting functioning within a family, opposed to family structure. Therefore, it is hypothesized that there will be no significant differences related to family processes (e.g., family functioning, parenting stress, adolescent adjustment, and social …

Birds Of A Feather: Exploring Social Facilitation Effects On Learning And Suboptimal Choice In Pigeons (Columba Livia), Peyton Mueller

Theses and Dissertations--Psychology

The social facilitation effect describes a change in the behavior of an individual due to the presence of another organism of the same species (i.e., a conspecific). Many theories exist that attempt to explain why this change in behavior exists across species. A set of four experiments were executed to best explain how pigeons learn in the presence of non-competing conspecifics. The first experiment sought to replicate an interesting effect previously found in cockroaches and rats, such that conspecific presence inhibits performance early in training but facilitates it with increased training. The second experiment placed the novel response acquired in …

Victimization, Symptoms Of Posttraumatic Stress Disorder, And Gender As Predictors Of Long-Term Substance Use Outcomes Of Patients In Community Treatment Programs, Christopher John Penn

Theses and Dissertations--Psychology

Violence victimization and posttraumatic stress disorder (PTSD) are prevalent among individuals with substance use disorders (SUDs). Current evidence is mixed regarding the impact they have on substance use-related treatment outcomes and few studies have examined victimization and PTSD symptoms together in the same model. The current study will evaluate whether there is an indirect effect of past year victimization on substance use-related treatment outcomes through the pathway of PTSD symptom severity, among a subsample of 1,613 adult men and women reporting a lifetime history of victimization who participated in the Kentucky Treatment Outcome Study (KTOS), a statewide study evaluating federally- …

Prenatal Ethanol Exposure Impairs Performance On Spatial And Tactile Sequential Discrimination Task In Juvenile Rats, Caleb S. Bailey

Theses and Dissertations--Psychology

Fetal alcohol spectrum disorders (FASDs) are a set of cognitive and behavioral abnormalities that arise in ~5% of children who have been prenatally-exposed to alcohol. Prenatal alcohol exposure (PAE) can cause impairments in learning acquisition, working memory, response inhibition, and attentional-set shifting that result in exaggerated deficits in executive function and impairments in goal-seeking behavior. There are standard procedures used in rodent research to address some components of these deficits, but few procedures are sensitive enough to comprehensively assess such deficits. To address this issue in FASDs research techniques, we developed a procedure that requires prolonged executive function in a …

Bipolarity Of Maladaptive Personality Traits In The Alternative Model Of Personality Disorders, Alexandra Hines

Theses and Dissertations--Psychology

It has been posited that extremely high or extremely low levels of any personality trait in the Five Factor Model of Personality can be maladaptive. However, the Alternative Model of Personality Disorders (AMPD) in Section III of the DSM-5 is composed almost exclusively of unipolar maladaptive traits. The lack of maladaptively low neuroticism and high extraversion fails to fully cover psychopathy; the lack of maladaptively high extraversion fails to cover histrionic personality disorder (HPD); the lack of maladaptively high agreeableness fails to cover dependent personality disorder (DPD); and the lack of maladaptively high conscientiousness fails to cover obsessive-compulsive personality disorder …

Personalized Longitudinal Network Models Of Alcohol Use: A Mechanistic Approach, Stephen Semcho

Theses and Dissertations--Psychology

AUD and high-risk drinking are significant public health concerns, and prevailing diagnostic models fail to account for the within-person variability in AUD presentation and the role of functional mechanisms that maintain drinking outcomes. The ETOH Framework highlights the importance of three primary superdomains that maintain and characterize AUD – reward salience, cognitive dyscontrol, and negative emotionality. The current study was the first attempt to investigate the role of the primary ETOH mechanisms, along with positive and negative affect, on alcohol use outcomes, using a novel approach to model individual-level networks of relations over time. This study gathered twice-daily diary data …

This Is Who I Am: Identity Development And Importance Among Diverse Youth From Lgbtq+ Parent Families, Madison T. Diomede

Theses and Dissertations--Psychology

Although the literature on identity and related constructs among adolescents, emerging adults, and diverse populations is growing, little research has investigated identity among adolescents and emerging adults specifically in the context of LGBTQ+ parent families. The present study seeks to fill this gap in the literature by qualitatively investigating identity development and importance among diverse youth with LGBTQ+ parents. Participants are 51 youth (ages 12-25 years) with at least one LGBTQ+ parent. Trained personnel conducted remote, audio-recorded, semi-structured interviews from December 2018-February 2020. Interviews included questions about participants’ individual identities and conversations they have had with their parents about those …

The Condom Use Outcomes And Sexual Functioning Of Young Adult Latinas: The Roles Of Intimate Partner Violence, Posttraumatic Stress Disorder, And Marianismo Beliefs, Jessica Flores

Theses and Dissertations--Psychology

Intimate partner violence (IPV) has been linked to poorer condom use outcomes and sexual functioning in women broadly. Limited studies have examined these associations in Latina samples through a culturally sensitive, trauma-informed lens. A sample of 383 U.S. Latina/Latinx/Hispanic women (Mage = 25.29 years; SD = 4.44) who had a past-year intimate relationship completed a cross-sectional online survey of IPV history, posttraumatic stress disorder (PTSD) symptoms, marianismo beliefs (i.e., traditional Latina gender role expectations), condom use outcomes (i.e., condom use attitudes, efficacy, negotiation efficacy, and behaviors) and sexual functioning. Linear regression models found that past-year IPV was positively related …

The Effects Of Escalated Fentanyl Intake On Decision-Making Dynamics, Trinity Shaver

Theses and Dissertations--Psychology

Opioid Use Disorder is characterized partially as a decision-making disorder. Decision-making theories, such as habit theory and relative value theory, have aimed to better understand the shift in preference for drug over other alternatives. In order to compare these two contrasting theories, an allomorphic concurrent choice task will run in tandem with an escalation procedure. Male and female Sprague-Dawley rats were tested for choice differences in an allomorphic choice procedure. Reward dimensions, such as relative reward rate, were manipulated within sessions, and magnitude (remifentanil dose), was manipulated between sessions. To study the effects of escalated fentanyl intake on relative valuation, …

The Role Of Maladaptive Emotion Socialization In Risk For Urgency And Problem Drinking In Adolescents, Emily Atkinson

Theses and Dissertations--Psychology

Negative urgency (NU; the tendency to act rashly when experiencing negative emotions) is a robust risk factor for a number of problem behaviors, including early adolescent drinking. Little is known about the factors that precede the development of NU, and hence the full etiology of this component of risk. The current study aimed to investigate the possibility that childhood maladaptive emotion socialization (MES; the tendency for children’s expressions of emotions to be met with punishment, minimized, or invoke a reaction of distress from their parents/caretakers) increases risk for the development of NU. Secondarily, the study tested whether MES predicts increased …

The Effects Of Social And Nonsocial Contextual Stimuli On The Renewal Of Cocaine Seeking, Bree Humburg

Theses and Dissertations--Psychology

Those with substance use disorders can undergo craving and relapse when re-exposed to a drug-associated context. This study determined if renewal of cocaine seeking is differentially controlled by contexts consisting of social and/or nonsocial stimuli. Experiment 1, rats self-administered cocaine in Context A which included a social peer and house light illumination. Following self-administration, rats were randomly assigned to an AAA or ABA group for extinction and renewal. For the AAA rats, context was similar to self-administration; for ABA rats, the drug-associated stimuli (peer and house light) were removed (Context B). Following extinction, renewal of cocaine seeking was examined by …

Seeing The System Vs Seeing The Individual: How Contextual Information And Framing Facilitate Perceptions Of Structural Inequality, Derek Kahng

Theses and Dissertations--Psychology

The current study investigates factors that facilitate adolescents' structural attributions. Namely, we focus on two main factors. First, we investigate if contextual information such as intergroup/intragroup comparisons and group/individual level framing of inequalities affects the likelihood of making structural attributions to race-based inequalities in academic achievement. Second, we investigate if the likelihood of making structural attributions differs based on individual characteristics, such as the individuals’ race/ethnicity, subjective and objective social status, and belief in meritocracy and a just world. Results and its implications will be discussed in the paper.

The Effects Of Extended Fructose Access On Relative Value And Demand For Fructose, Saccharin, And Ventral Tegmental Stimulation, Megan Halloran

Theses and Dissertations--Psychology

Globally, food addiction (FA) is a growing area of research and is largely attributed to the availability of foods that are both energy dense and high in fats and sugars. Further, it has been suggested, that sugar and fat, when consumed frequently, have properties similar to drugs of abuse. While the validity of FA is questioned, researchers have drawn parallels between substance use disorder (SUD) and FA. For example, sugar binge models emphasize craving, withdrawal and binging as primary components of FA, which are also hallmarks of SUD. Additionally, both natural rewards, like sugars, and drug rewards act on the …

Trait Impulsivity And Acute Alcohol Responses As Markers Of Binge Drinking In Young Adults, Holley Jamison

Theses and Dissertations--Psychology

Impulsivity, tolerance to alcohol-induced motor impairment, and high sensitivity to alcohol-induced disinhibition each have empirical support as markers of alcohol-related problems. However, research on alcohol response and personality-based markers of risk have remained largely independent lines of research. This dissertation examined how individual differences in these well-established markers may interact to additively contribute to heavy drinking.

Participants were 96 young adults (21-33 years old). with no history of AUD. They self-reported their drinking habits over the prior 90 days, and behavioral tasks measuring disinhibition and motor impairment were administered on two separate days following two alcohol doses (active [0.65 g/kg] …

Calcium Imaging Of Central Amygdala Activity After Fentanyl Escalation, Samantha Malone

Theses and Dissertations--Psychology

Evidence suggests that rats given long access (LgA) sessions to self-administer (SA) opioids escalate their intake, while also showing greater withdrawal severity and drug-induced reinstatement compared to rats maintained on short access (ShA) daily SA sessions. Little is known about the neural changes that occur during opioid escalation that may impact withdrawal and relapse. Past work examining opioid SA using ShA sessions in rodents has identified the central amygdala (CeA) as an area of interest that becomes hyperactive in acute withdrawal and may be involved in the incubation of craving that occurs after protracted withdrawal. However, these studies have not …

Pain Interference Across Chronic Pain Populations: Variability And Associated Psychosocial Processes, Stephanie Judge

Theses and Dissertations--Psychology

Chronic pain is one of the most common health complaints, yet the limited effectiveness of existing treatment options suggests that chronic pain is still not fully understood. The goals of this study are to identify and organize well-established and emerging psychosocial factors associated with pain interference, clarify the nature of between- and within-diagnostic group differences in psychosocial and demographic factors associated with pain interference, and identify interactions among diagnostic and psychosocial factors associated with pain interference.

Community-dwelling participants (N = 284) completed a one-time survey which included demographic information, information about pain and diagnosis, and five existing measures that assess …

Early Maturing Out Of Problematic Alcohol Use, Sarah J. Peterson

Theses and Dissertations--Psychology

Most research suggests that alcohol use peaks in the college years then declines into the mid-thirties (Jochman & Fromme, 2010). However, there is evidence that some individuals mature out earlier: downward trends for some individuals begin in college, with as many as one third of students decreasing their drinking (Baer et al., 2001). It is crucial to identify factors that differentiate those who decrease their drinking early from those who persist in high levels of consumption; doing so would clarify risk for college-related alcohol problems and perhaps subsequent alcohol use disorder, and aid in earlier targeted prevention and intervention. This …

Mental Health In The Courtroom: How Victim Mental Illness Impacts Juror Decision-Making In A Rape Case, Mary M. Levi

Theses and Dissertations--Psychology

The influence of mental illness on jury decision-making has rarely been investigated, and even fewer studies have examined how jurors perceive a victim with mental illness. The present study investigated the effect of victim mental illness on jury decision-making in a rape trial using a 3 (victim mental health status: schizophrenia, depression, no illness) x 2 (participant gender: female, male) between-subjects design. I hypothesized that mock jurors would render fewer guilty verdicts in the schizophrenia condition compared to the depression condition, and render fewer guilty verdicts in the schizophrenia and depression conditions compared to the control. I also hypothesized that …

Experiential-Based Feedback During Alcohol Intoxication And Its Effect On Drinkers’ Risk Awareness, Alexandra R. Kelly

Theses and Dissertations--Psychology

The prevalence of alcohol-impaired driving injuries and fatalities has not decreased for over a decade despite strategies to reduce and prevent driving under the influence of alcohol (DUI). In 2019, 10,142 people died in alcohol-impaired driving crashes in the United States, which totaled to 28% of all traffic fatalities for the year. DUI interventions have been found to have moderate effects on reducing DUI recidivism. Prevention research has identified a lack of risk awareness in DUI offenders and this could be a target to motivate behavioral change. However, the training to increase levels of risk awareness needs to occur in …

"Think Of The Situation In A Positive Light": A Look At Cognitive Reappraisal, Affective Reactivity And Health, Jessica Chloe Maras

Theses and Dissertations--Psychology

How individuals regulate their emotions is critical for maintaining health and well-being. For example, reframing a stressful situation in a positive light, a form of cognitive reappraisal, is beneficial for health and well-being outcomes. However, it is currently unclear why this relationship exists. One potential mechanism could be how one emotionally reacts to stressors in daily life, termed affective reactivity. The current study examined longitudinal associations that spanned 20 years between cognitive reappraisal and health outcomes and subjective well-being and if affective reactivity mediated this relationship. Participants completed waves 1-3 of the Midlife in the United States (MIDUS) Survey series …

Effects Of An Online Insomnia Intervention On Sleep And Alcohol Consumption, Justin Verlinden

Theses and Dissertations--Psychology

Alcohol use disorder (AUD) and insomnia are highly comorbid, due in part to the use of alcohol as a sleep aid among individuals with insomnia. Initial studies have shown that cognitive behavioral therapy for insomnia (CBT-I), the first-line treatment for insomnia, is moderately successful at improving both sleep and drinking outcomes in heavy drinkers with insomnia. However, CBT-I is expensive and not widely available. Online CBT-I could be a more accessible alternative. One online CBT-I program, Sleep Healthy Using the Internet (SHUTi), is especially promising due to its high efficacy in treating insomnia and its individualized and interactive platform. Here …

Examining The Indirect Effect Of Trauma On Obsessive-Compulsive Symptoms Through Responsibility/Threat Beliefs, Emily E. Fenlon

Theses and Dissertations--Psychology

Inflated responsibility beliefs and threat estimations have been implicated in the etiology and maintenance of obsessive-compulsive (OC) symptoms. Research suggests that early life experiences that involve actual or perceived serious harm to oneself or others may lead to inflated responsibility/threat beliefs and OC symptoms. Research has yet to explore if traumatic experiences influence responsibility/threat beliefs or if the associations between trauma and OC symptoms are at all dependent on trauma’s influence on responsibility/threat beliefs. The present study aims to examine associations among exposure to potentially traumatic events (PTEs), responsibility/threat beliefs, and OC symptoms. A sample of 886 undergraduate students completed …

Latent Classes Of Symptom Trajectory In A Brief Treatment For Borderline Personality Disorder, Doug Terrill

Theses and Dissertations--Psychology

It is likely that patients with BPD progress through treatment in different ways. Characterizing symptom trajectories during treatment can facilitate the identification of distinct treatment responses, which may be shared by subgroups of patients. Researchers have consistently identified multiple distinct symptom trajectories among individuals with common psychopathological conditions, but no research to date has attempted to do so among patients with BPD. This study used latent growth mixture modeling to identify and characterize distinct classes of symptom trajectories among patients receiving an 18-week cognitive-behavioral treatment for BPD. Two distinct BPD symptom trajectories were identified in this sample, which were primarily …

Blocking The Acquisition Of Ethanol-Induced Conditioned Place Preference With 11, 21-Bisphenyl-19-Norpregnane (Pt150) In Coturnix Quail, Mia Radevski

Theses and Dissertations--Psychology

Alcohol use disorder (AUD) has been associated with a dysregulated stress system. Therefore, regulating stress hormones has been investigated as a potential therapeutic target for AUDs. The purpose of the current study was to investigate whether a stress hormone receptor antagonist, PT150, would block the rewarding properties of ethanol. Quail were used as subjects because a conditioned place preference (CPP) apparatus that utilized visual cues was used, and quail readily attend to visual cues. Visual cues in the environment have been shown to become associated with alcohol effects and later induce craving. Starting on day one, quail were pretreated with …