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A Comparison Of The Relative Magnitude Of Combinations Of Relapse Types In Rats, Mary Bridges
A Comparison Of The Relative Magnitude Of Combinations Of Relapse Types In Rats, Mary Bridges
Theses
Applied behavior analysis uses scientifically derived methods to create treatments for socially significant behaviors. A threat to these successful treatments is the recurrence of previously reduced behavior (i.e., relapse). Relapse can be categorized into several types depending on the variables that induce relapse. Three types prevalent in clinical settings are reinstatement (i.e., induced by re-exposure to reinforcers or stimuli paired with the target behavior), renewal (i.e., induced by changes in context), and resurgence (i.e., induced by worsening of alternative reinforcement). Because relapse is harmful to long-term treatment maintenance, prior research has developed and tested mitigation strategies for these relapse types, …
Influences Of Salvinorin A And Sex Differences On Depressive- And Anxiety-Like Behaviors In A Chronic Mild Stress Paradigm, Sarah Mitchell
Influences Of Salvinorin A And Sex Differences On Depressive- And Anxiety-Like Behaviors In A Chronic Mild Stress Paradigm, Sarah Mitchell
Theses
Kappa opioid receptors are colocalized with dopamine receptors and are frequently associated with depression, anxiety, stress, and drug use and abuse. KOR antagonism has widely been considered anti-depressive and anxiolytic in animal models while agonism is pro-depressive and anxiogenic. However, recent findings suggest that SalvA, a natural kappa agonist derived from a plant in the mint family, can reduce depressive- and anxiety-like behavior in rats. The current study investigated the effects of chronic mild stress on behavior, attenuation by SalvA, and sex differences. 52 Long-Evans rats, 26 males and 26 females, were exposed to six weeks of CMS. Animals received …