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Antagonizing Serotonin 2a (5-Ht2a) Receptors Does Not Attenuate Methamphetamine-Induced Expression Of Conditioned Place Preference In Female And Male Rats, Nicole C. Reyna
Psychology ETDs
Despite the need, there are currently no FDA-approved pharmacological treatments for methamphetamine use disorders. Cue-induced craving during drug withdrawal remains a significant contributor to high relapse rates. Thus, understanding the neurobiological mechanisms of cue-induced drug-seeking behavior is critical. Previous research indicates that the selective 5-HT2A antagonist M100907 attenuates the acquisition of methamphetamine-induced conditioned place preference (CPP) in male and female adult rats. The present study examines the effects of M100907 on expression of methamphetamine-induced drug-seeking behavior using a biased CPP design in adult male and female Long Evans rats (PND 95-112). During conditioning, rats were administered either saline or …
Antagonizing Serotonin 2a (5-Ht2a) Receptors Attenuates Methamphetamine-Induced Reward And Blocks Methamphetamine-Induced Anxiety-Like Behaviors In Adult Male Rats, John T. Madden
Psychology ETDs
Methamphetamine (Meth) is a highly addictive and widely abused psychostimulant. Research indicates that the selective 5-HT2A receptor antagonist M100907 attenuates several psychostimulant-induced behaviors, including conditioned place preference (CPP). However, these findings have not yet been extended to Meth. The present study investigated the effects of M100907 on the acquisition of Meth-CPP and Meth-induced anxiety.
Adult male rats were tested using an unbiased two-chamber apparatus across eight consecutive days. Prior to Meth administration, rats were pretreated with M100907 and placed into their initially non-preferred chamber. After four Meth conditioning sessions, the effects of M100907 on Meth-induced changes in CPP were …