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The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
Legacy Theses & Dissertations (2009 - 2024)
Numerous neurodevelopmental and neuropsychiatric diseases have a distinct sex bias in
The Role Of The Progesterone Receptor In The Development Of The Ventromedial Nucleus And Female Sexual Behaviors, Keith L. Gonzales
The Role Of The Progesterone Receptor In The Development Of The Ventromedial Nucleus And Female Sexual Behaviors, Keith L. Gonzales
Legacy Theses & Dissertations (2009 - 2024)
Steroid induced gene transcription plays an important role in neural sex differences within many mammalian species. Steroid hormones actions within the developing brain have profound, permanent effects in the development of neurochemical processes and behaviors. Within the developing ventromedial nucleus of the hypothalamus (VMN), a potent transcription factor, the progesterone receptor (PR), is highly expressed within female rats. Furthermore, the regulation of PR within the developing VMN of the female rat is anatomically and developmentally specific. Typically, PR expression is highly dependent on the activity of estradiol acting at ERα. As such, circulating levels of estradiol act to induce PR …