Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
The Serotonin Transporter Gene Linked Polymorphic Region Is Associated With The Behavioral Response To Repeated Stress Exposure In Infant Rhesus Macaques, Simona Spinelli, Melanie L. Schwandt, Stephen G. Lindell, Markus Heilig, Stephen J. Suomi, James Dee Higley, David Goldman, Christina S. Barr
The Serotonin Transporter Gene Linked Polymorphic Region Is Associated With The Behavioral Response To Repeated Stress Exposure In Infant Rhesus Macaques, Simona Spinelli, Melanie L. Schwandt, Stephen G. Lindell, Markus Heilig, Stephen J. Suomi, James Dee Higley, David Goldman, Christina S. Barr
Faculty Publications
The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5- HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across …